2 Results for "

NSC 32944 monohydrochloride

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "NSC 32944 monohydrochloride" in MCE Product Catalog:

2
Cephaeline
Cephaeline
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2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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Cephaeline hydrochloride
Cephaeline hydrochloride
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Cat. No.: HY-N2076
CAS No.: 3738-70-3
Synonyms: (-)-Cephaeline hydrochloride; NSC 32944 monohydrochloride
Category:  

Infection Alkaloids other families Monophenols Phenols Plants Disease Research Fields Isoquinoline Alkaloids

Target:  

Reactive Oxygen Species (ROS) SARS-CoV Ferroptosis MDM-2/p53 Keap1-Nrf2 Glutathione Peroxidase Flavivirus

Cephaeline hydrochloride ((-)-Cephaeline (hydrochloride); NSC 32944 (monohydrochloride)) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline hydrochloride induces Ferroptosis by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline hydrochloride inhibits cancer cell proliferation, migration and tumor growth. Cephaeline hydrochloride inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline hydrochloride can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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