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2247919-28-2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2247919-28-2" in MCE Product Catalog:

Cat. No.: HY-126249
CAS No.: 2247919-28-2
Purity:  98.31%
Research Areas:  

Cancer

AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3 Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM .
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