2247919-28-2
Chemical Structure
AAPK-25
- CAS No.: 2247919-28-2
- Formula:C21H13Cl2N3O2S
- Molecular Weight:442.32
IUPAC Name: 6-(3,4-dichlorobenzamido)-N-(thiazol-2-yl)-2-naphthamide
InChIKey: MRITYVDXXFOOAU-UHFFFAOYSA-N
SMILES: ClC1=CC(C(NC2=CC=C(C=C(C(NC3=NC=CS3)=O)C=C4)C4=C2)=O)=CC=C1Cl
Biological Activity: AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM[1].
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AAPK-25 | 98.09% | AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM. | ||||||||||||||||||||
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Keywords
