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2866266-56-8

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "2866266-56-8" in MCE Product Catalog:

1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide
1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide
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Cat. No.: HY-N20682
CAS No.: 2866266-56-8
Category:  

Terpenoids Sesquiterpenes Plants Compositae Piptanthus nepalensis (Hook.) D. Don

Target:  

NO Synthase COX NF-κB Arginase

1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide is a neuroprotective agent. 1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide reduces the protein expression levels of iNOS and COX-2, blocks the DNA-binding activity of NF-κB, and inhibits nitric oxide production. 1-Hydroxy-4αH-1,10-secoeudesma-5(6),10(14),11(13)-trien-12,8β-olide promotes the polarization of microglia to the M2 phenotype by inducing the production of Arg-1, and alleviates cell damage induced by H2O2 and 6-Hydroxydopamine (HY-B1081) .
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