100 Results for "

2L-2,3,4,6/5-Pentahydroxycyclohexanone

" in MedChemExpress (MCE) Product Catalog:
Products (100)

100 Results for "2L-2,3,4,6/5-Pentahydroxycyclohexanone" in MCE Product Catalog:

32
32 Publications Verification
Cat. No.: HY-P0023
CAS No.: 161552-03-0
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM. Cyclo(-RGDfK) potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
loading...
    loading...
32
32 Publications Verification
Cat. No.: HY-P0023A
CAS No.: 500577-51-5
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(-RGDfK) TFA is a potent and selective inhibitor of the αvβ3 integrin, with an IC50 of 0.94 nM . Cyclo(-RGDfK) TFA potently targets tumor microvasculature and cancer cells through the specific binding to the αvβ3 integrin on the cell surface .
loading...
    loading...
7
7 Cited Publications
Cat. No.: HY-P1934
CAS No.: 14705-60-3
Synonyms: Cyclo(phenylalanylprolyl); A-64863
Cyclo(Phe-Pro) (Cyclo(phenylalanylprolyl)) is a quorum-sensing molecule of Vibrio vulnificus that specifically interacts with RIG-I, inhibiting RIG-I polyubiquitination, suppressing IRF-3 activation, and reducing type I interferon production. Cyclo(Phe-Pro) enhances susceptibility to HCV and influenza virus and also alleviates plant aluminum toxicity stress. The mechanism of Cyclo(Phe-Pro) involves the regulation of host immune signaling pathways, bacterial virulence gene expression, and plant antioxidant systems, making it a promising candidate for research in viral infections, bacterial virulence regulation, and agricultural stress resistance .
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100563A
CAS No.: 217099-14-4
Purity:  99.83%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
loading...
    loading...
4
4 Cited Publications
Cat. No.: HY-100563
CAS No.: 250612-42-1
Purity:  99.92%
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with an IC50 of 20 nM.
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P2300
CAS No.: 862772-11-0
Synonyms: Cyclo(RGDfC)
Target:  

Integrin

Research Areas:  

Cancer

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC), a cyclic RGD peptide which has high affinity to αvβ3, can disrupt cell integrin interactions. Cyclo(Arg-Gly-Asp-D-Phe-Cys) inhibits pluripotent marker expression in embryonic stem cells (ESCs) and the tumorigenic potential of mESCs in vivo. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-107245
CAS No.: 164991-89-3
Purity:  99.51%
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP) .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P0231
CAS No.: 1088543-62-7
Target:  

GHSR

Research Areas:  

Metabolic Disease Endocrinology

AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P5712
CAS No.: 113-73-5
Synonyms: Gramicidin soviet
Research Areas:  

Infection

Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na +/K +-ATPase, tobacco leaf plasma membrane Mg 2+/K +-ATPase, and rat heart plasma membrane Ca 2+-ATPase, respectively .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-131109
CAS No.: 5845-66-9
Purity:  99.70%
Target:  

Peptides

Research Areas:  

Others

Cyclo(Gly-Tyr) is a cyclic dipeptide .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P0031
CAS No.: 756500-23-9
Target:  

Integrin

Research Areas:  

Others

Cyclo(RADfK) can be used as a control for Cyclo(-RGDfK) (HY-P0023) .
loading...
    loading...
Cat. No.: HY-P1934A
CAS No.: 3705-26-8
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC50 of 24 µM in the DPPH assay .
loading...
    loading...
Cat. No.: HY-101402
CAS No.: 53109-32-3
Synonyms: Cyclohistidyl-proline; Histidylproline diketopiperazine
Cyclo(his-pro) (Cyclo(histidyl-proline)) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .
loading...
    loading...
Cat. No.: HY-P1938
CAS No.: 2854-40-2
Target:  

Bacterial

Cyclo(L-Pro-L-Val) is an antimicrobial and anti-inflammatory agent. Cyclo(L-Pro-L-Val) has toxic activity against plant pathogens such as R. fascians LMG 3605, and its potency may be comparable to that of Chloramphenicol (HY-B0239). Cyclo(L-Pro-L-Val) can inhibit the phosphorylation of IKKα, IKKβ, NF-κB, etc., and the activation of iNOS and COX-2, thereby exerting anti-inflammatory activity. Cyclo(L-Pro-L-Val) can be used in the research of biopesticides in the agricultural field, as well as in the research of inflammation-related diseases .
loading...
    loading...
Cat. No.: HY-P10304
CAS No.: 74838-83-8
Synonyms: Cyclo(Pro-Arg)
Target:  

Fungal

Research Areas:  

Others

Cyclo(Arg-Pro) (Cyclo(Pro-Arg)) is an inhibitor for chitinase. Cyclo(Arg-Pro) inhibits cell separation of Saccharomyces cerevisiae, without affecting its growth. Cyclo(Arg-Pro) inhibits the morphological change of Candida albicans from yeast form to filamentous form .
loading...
    loading...
Cat. No.: HY-P10856
CAS No.: 3085809-95-3
Target:  

P-glycoprotein

Research Areas:  

Cancer

CPI1 is a multidrug resistance protein 1 (MRP1) inhibitor with a Ki value of 100 nM. CPI1 binds to the same substrate-binding site as leukotriene C4, stabilizes MRP1 in an apo-like inward-facing conformation, blocks the conformational changes required for ATP hydrolysis and substrate transport, and inhibits the ATPase activity of human and bovine MRP1. CPI1 serves as a tool for investigating the substrate transport mechanism of MRP1. CPI1 is applicable to research related to cancer multidrug resistance .
loading...
    loading...
Cat. No.: HY-126810A
Purity:  99.80%
Target:  

Fungal

Research Areas:  

Infection

NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections .
loading...
    loading...
Cat. No.: HY-P1936
CAS No.: 3705-27-9
Cyclo(Gly-L-Pro) is a Alkaloids product that can be isolated from the roots of Panax notoginseng (Burk.)F.H.Chen .
loading...
    loading...
Cat. No.: HY-101402A
CAS No.: 936749-56-3
Purity:  99.06%
Synonyms: Cyclohistidyl-proline TFA; Histidylproline diketopiperazine TFA
Cyclo(his-pro) TFA (Cyclo(histidyl-proline) TFA) is an orally active cyclic dipeptide structurally related to tyreotropin-releasing hormone . Cyclo(his-pro) TFA could inhibit NF-κB nuclear accumulation. Cyclo(his-pro) TFA can cross the brain-blood-barrier and affect diverse inflammatory and stress responses .
loading...
    loading...
Cat. No.: HY-75564
CAS No.: 4526-77-6
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM .
loading...
    loading...