7 Results for "

2PY

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "2PY" in MCE Product Catalog:

Cat. No.: HY-113432
CAS No.: 701-44-0
Purity:  99.94%
Synonyms: 2PY
Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
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Cat. No.: HY-113432R
CAS No.: 701-44-0
Synonyms: 2PY (Standard)
Nudifloramide (Standard) is the analytical standard of Nudifloramide. This product is intended for research and analytical applications. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
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Cat. No.: HY-112338
CAS No.: 823828-18-8
Purity:  98.29%
Synonyms: CPD188
Target:  

STAT Apoptosis

Research Areas:  

Cancer

C188 (CPD188) is a STAT3 inhibitor with anticancer effects. C188 inhibits STAT3 SH2/pY-peptide binding (IC50 of 20 µM against pY-peptide binding) and IL-6-mediated STAT3 phosphorylation. C188 is selective for STAT3 over STAT1. C188 inhibits nuclear-to-cytoplasmic translocation of Stat3. C188 shows highly active induces apoptosis in breast cancer cell lines with constitutive Stat3 activation (EC50s of 0.73 µM, 3.96 µM, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively) .
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Cat. No.: HY-P990651

Target:  

TREM receptor

Research Areas:  

Cancer

PY314 is a humanized antibody targeting TREM2. PY314 binds TREM2 on tumor-associated macrophages, depletes TREM2-high tumor-associated macrophages, reduces pro-tumorigenic M2 macrophage infiltration, increases CD8 + T cell, NK cell, and M1 macrophage infiltration, creates a proinflammatory tumor microenvironment, and promotes antitumor immune responseS. PY314 can be used for the research of platinum-resistant ovarian cancer, advanced solid tumors, breast cancer, and advanced refractory solid tumors [2] .
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Cat. No.: HY-113432S
CAS No.: 1207384-48-2
Purity:  ≥99.0%
Nudifloramide-d3 (2PY-d3) is the deuterium labeled Nudifloramide. Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
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Cat. No.: HY-113432S1
CAS No.: 2012598-72-8
Synonyms: 2PY-d6
Nudifloramide-d6 (2PY-d6) is deuterium-labeled Nudifloramide (HY-113432) .
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Cat. No.: HY-113432S2
Synonyms: 2PY-13C,d3
Nudifloramide- 13C,d3 (2PY- 13C,d3) is the 13C- and deuterium labeled Nudifloramide (HY-113432). Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro .
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