1 Result for "

3111011-76-5

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "3111011-76-5" in MCE Product Catalog:

Cat. No.: HY-182057
CAS No.: 3111011-76-5
Research Areas:  

Cancer

ALK degrader 4 is a ALK HyT degrader with an IC50 of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021)) .
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