2. PROTAC Protein Tyrosine Kinase/RTK
  3. HyT Anaplastic lymphoma kinase (ALK)
  4. ALK degrader 4

ALK degrader 4 is a ALK HyT degrader with an IC50 of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021)).

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ALK degrader 4

ALK degrader 4 Chemical Structure

CAS No. : 3111011-76-5

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ALK degrader 4 Related Antibodies

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Description

ALK degrader 4 is a ALK HyT degrader with an IC50 of 0.74 nM. ALK degrader 4 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and induces proteasomal degradation of ALK. ALK degrader 4 inhibits cancer cell proliferation. ALK degrader 4 can be used in research related to non-small cell lung cancer (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Norbornene (HY-W013021))[1].

In Vitro

ALK degrader 4 (compound B7) potently inhibits the proliferation of H3122 cells over 7 days, with an IC50 value of 68.98 nM[1].
ALK degrader 4 (0.05-2 μM; 24 h) induces concentration-dependent degradation of ALK protein in H3122 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALK degrader 4 Related Antibodies

Western Blot Analysis[1]

Cell Line: H3122 cells
Concentration: 0.05, 0.1, 0.5, 1, 2 μM
Incubation Time: 24 h
Result: Reduced ALK protein levels in H3122 cells in a concentration-dependent manner.
Molecular Weight

690.21

Formula

C36H45ClN7O3P
CAS No.
SMILES

CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC=C(N4CCC(N5CCN(C(C6C(C7)C=CC7C6)=O)CC5)CC4)C=C3OC)=NC=C2Cl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALK degrader 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALK degrader 43111011-76-5ALK degrader4ALK degrader-4HyTAnaplastic lymphoma kinase (ALK)Hydrophobie taggingAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246hydrophobic residuesnon-small-cell lung cancerproteasomal ALK degradationALK proteinALKcancer cellsEML4-ALK fusion proteinALK binding pocketH3122 cellsALK kinase activityInhibitorinhibitorinhibit

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ALK degrader 4
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