1 Result for "

639087-64-2

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "639087-64-2" in MCE Product Catalog:

Cat. No.: HY-118900
CAS No.: 639087-64-2
Target:  

EGFR Notch CDK Apoptosis Akt

Research Areas:  

Cancer

CP-654577 is a selective ErbB2 inhibitor with an IC50 of 11 nM. CP-654577 downregulates the Notch1 signaling pathway. CP-654577 upregulates p27 kip1, reduces the levels of Cyclins D and E, and inhibits G1 phase progression of the cell cycle. CP-654577 induces cell Apoptosis, downregulates activated Akt, and suppresses tumor growth in athymic mice. CP-654577 can be used in breast cancer-related research .
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