1 Result for "

7,8-Dihydroxycoumarin (Standard)

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "7,8-Dihydroxycoumarin (Standard)" in MCE Product Catalog:

Daphnetin (Standard)
Daphnetin (Standard)
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Cat. No.: HY-N0281R
CAS No.: 486-35-1
Synonyms: 7,8-Dihydroxycoumarin (Standard)
Category:  

Daphne  Thymelaeaceae Coumarins Phenols Polyphenols Phenylpropanoids Plants

Target:  

Reference Standards EGFR PKA PKC Autophagy Apoptosis AMPK Akt mTOR Reactive Oxygen Species (ROS) Caspase Bcl-2 Family PARP Parasite

Daphnetin (Standard) is the analytical standard of Daphnetin. This product is intended for research and analytical applications. Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1 , ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research .
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