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AChE/BChE-IN-37

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-183760
    AChE/BChE-IN-37

    		Cholinesterase (ChE) HSP GSK-3 Amyloid-β Neurological Disease Inflammation/Immunology
    AChE/BChE-IN-37 is a blood-brain barrier-permeable AChE/BChE inhibitor, with an IC50 of 73.65 μM against electric eel-derived AChE and an IC50 of 82.93 μM against horse-derived BChE. AChE/BChE-IN-37 exhibits chelating activity towards Cu 2+, Ca 2+, Mg 2+, Fe 2+ and Zn 2+. AChE/BChE-IN-37 interacts with HSP90AA1 and GSK-3β. AChE/BChE-IN-37 inhibits the self-induced aggregation of Aβ1-42. AChE/BChE-IN-37 suppresses LPS-induced NO production in cells. AChE/BChE-IN-37 can be used in research related to Alzheimer's disease and inflammatory diseases .
    AChE/BChE-IN-37

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