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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
1032 Results for "
AR
" in MedChemExpress (MCE) Product Catalog:
Products (1032)
1032 Results for "AR" in MCE Product Catalog:
229
Target:
Research Areas:
Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator .
74
74 Cited Publications
Synonyms: LevARterenol; L-Noradrenaline
74
74 Cited Publications
Synonyms: LevARterenol hydrochloride; L-Noradrenaline hydrochloride
74
74 Cited Publications
Synonyms: LevARterenol bitARtrate monohydrate; L-Noradrenaline bitARtrate monohydrate
74
74 Cited Publications
Synonyms: LevARterenol tARtrate; L-Noradrenaline tARtrate
70
70 Cited Publications
Synonyms: 17-AAG; NSC 330507; CP 127374
Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90 . Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression .
58
58 Cited Publications
Cat. No.: HY-Y1269
CAS No.: 12125-02-9
52
52 Cited Publications
Target:
Research Areas:
AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.
50
Category:
Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields Endocrinology
Target:
50
Category:
Cardiovascular Disease Alkaloids Neurological Disease Other Alkaloids Endogenous metabolite Disease Research Fields
Target:
47
Research Areas:
Cardiovascular Disease Neurological Disease Inflammation/Immunology
Zenidolol (ICI-118551) is a selective β2-adrenergic receptor antagonist with Ki values of Zenidolol for β2, β1 and β3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking β2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research .
21
21 Cited Publications
Synonyms: AR 0133418; GSK 3β inhibitor VIII; AR 014418
Target:
Research Areas:
AR-A014418 is a potent, selective and ATP-competitive GSK3β inhibitor (IC50=104 nM; Ki=38 nM) .
21
21 Cited Publications
Target:
Research Areas:
Bicalutamide is an orally active non-steroidal androgen receptor (AR) antagonist. Bicalutamide can be used for the research of prostate cancer .
16
16 Cited Publications
Target:
Research Areas:
AR7 is an atypical RARA/RARα (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .
16
16 Cited Publications
Cat. No.: HY-19532
CAS No.: 139180-30-6
Target:
Research Areas:
ZM241385 is a potent, high affinity and selective adenosine A2a receptor (A2AR) antagonist with a Ki value of 1.4 nM .
16
15
Target:
Research Areas:
Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM .
15
15
15 Cited Publications
Target:
Research Areas:
AU-15330 is a proteolysis-targeting chimera (PROTAC) degrader of the SWI/SNF ATPase subunits, SMARCA2 and SMARCA4. AU-15330 induces potent inhibition of tumour growth in xenograft models of prostate cancer and synergizes with the AR antagonist enzalutamide. AU-15330 induces disease remission in castration-resistant prostate cancer (CRPC) models without toxicity .
14
14 Cited Publications
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Research Areas:
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
