915087-33-1
915087-33-1
Chemical Structure
Enzalutamide
Synonym(s): MDV3100
- CAS No.: 915087-33-1
- Formula:C21H16F4N4O2S
- Molecular Weight:464.44
IUPAC Name: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-N-methylbenzamide
InChIKey: WXCXUHSOUPDCQV-UHFFFAOYSA-N
SMILES: S=C(N(C(C1(C)C)=O)C2=CC=C(C#N)C(C(F)(F)F)=C2)N1C3=CC(F)=C(C(NC)=O)C=C3
Biological Activity: Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Enzalutamide | 99.97% | Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator. | ||||||||||||||||||||
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Enzalutamide (Standard) | 99.98% | Enzalutamide (Standard) is the analytical standard of Enzalutamide. This product is intended for research and analytical applications. Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. Enzalutamide is an autophagy activator. | ||||||||||||||||||||
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Enzalutamide-d6 | 99.85% | Enzalutamide-d6 (MDV3100-d6) is a deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. | ||||||||||||||||||||
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Deutenzalutamide-d3 | 99.80% | Deutenzalutamide (Enzalutamide-d3) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.92
HY-70002ASN-Desmethyl enzalutamide-d6 -
Similarity Score 0.91
HY-70002ARN-Desmethyl enzalutamide (Standard) -
Similarity Score 0.90
HY-70002BSEnzalutamide carboxylic acid-d6 -
Similarity Score 0.88
HY-70002BEnzalutamide carboxylic acid -
Similarity Score 0.84
HY-70002BREnzalutamide carboxylic acid (Standard) -
Similarity Score 0.82
HY-111145RD162 -
Similarity Score 0.77
HY-114246Varilutamide -
Similarity Score 0.75
HY-112689Androgen receptor antagonist 9 -
Similarity Score 0.75
HY-153772Androgen receptor antagonist 8 -
Explore the MedChemAI to find more analogs
References
- [1]. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science, 2009, 324 (5928), 787-790. [Content Brief]
- [2]. Scher HI, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study. Lancet, 2010, 375(9724), 1437-1446. [Content Brief]
