2 Results for "

Activin receptor II ligand trap

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Activin receptor II ligand trap" in MCE Product Catalog:

1
1 Cited Publications
Cat. No.: HY-P99590A
Synonyms: RAP-011
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .
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Cat. No.: HY-P990733
CAS No.: 2769700-97-0
Synonyms: KER-012

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

Cibotercept (KER-012) is a novel, modified, investigational activin receptor type IIB (ActRIIB) ligand trap designed to target select TGF-β ligands, including activins A and B, GDFs 8 and 11, to rebalance the defective activin receptor type II signaling observed in PAH .
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