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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
Acyl Carrier Protein
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "Acyl Carrier Protein" in MCE Product Catalog:
10
Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
1
1 Cited Publications
Target:
Research Areas:
Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
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1 Cited Publications
Cat. No.: HY-P71828
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MCAT; Malonyl-CoA-Acyl Carrier Protein TransAcylase, Mitochondrial; Malonyl-CoA-Acyl Carrier Protein TransAcylase; Malonyl CoA:ACP Acyltransferase (Mitochondrial); MCT; Mitochondrial Malonyl CoA:ACP Acyltransferase; MT; [Acyl-Carrier-Protein] S-Malonyltra
Species:
Staphylococcus aureus
Source:
P. pastoris
Cat. No.: HY-P1743
CAS No.: 66851-75-0
Cat. No.: HY-134421
CAS No.: 102680-35-3
Target:
Cat. No.: HY-W015580
CAS No.: 4695-62-9
Cat. No.: HY-N6711
CAS No.: 57749-43-6
Cat. No.: HY-W585865
CAS No.: 112710-84-6
Synonyms: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris
Target:
Diazaborine is an inhibitor for enoyl-acyl carrier protein (enoyl ACP) in an NAD+-dependent manner. Diazaborine exhibits antibacterial activity, MIC for E. coli and K. pneumoniae is 25 and 3.12 μg/mL .
Cat. No.: HY-W747491
CAS No.: 1365620-36-5
Triclosan- 13C12 is 13C labeled Triclosan (HY-B1119). Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 μM and 10 μM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
Cat. No.: HY-W653962
CAS No.: 2726926-25-4
Triclosan (Standard) is the analytical standard of Triclosan. This product is intended for research and analytical applications. Triclosan is a broad-spectrum antibacterial agent that inhibits bacterial fatty acid synthesis at the enoyl-acyl carrier protein reductase (FabI) step. Triclosan inhibits E. coli enoyl-acyl carrier protein reductase (FabI) and FabI containing a glycine-to-valine substitution at position 93 (FabIG93V) with IC50s of 2 µM and 10 µM, respectively. Triclosan causes apoptotic effect in cultured rat neural stem cells (NSC). Triclosan exacerbates colitis and colitis-associated colorectal tumorigenesis in animal models .
Cat. No.: HY-E71774A
Target:
Research Areas:
3-Oxoacyl-[acyl-carrier-protein] reductase (NADH) (EC 1.1.1.212) forms part of the fatty acid synthase system in plants.
Cat. No.: HY-118205
CAS No.: 637772-75-9
SCH-538415 is a novel acyl carrier protein synthase inhibitor isolated from an unknown bacterial microorganism. The structural elucidation of compound 1 was completed by analyzing spectral data including UV, MS and 2D-NMR spectra. Compound 1 showed inhibitory activity in the acyl carrier protein synthase (AcpS) test with an IC50 value of 4.19 μM and exhibited antibacterial activity against Staphylococcus aureus in the agar diffusion test.
Cat. No.: HY-E71774
Target:
Research Areas:
3-Oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100) is an NADPH-dependent β-ketoacyl-ACP reductase and a key enzyme in the bacterial type II fatty acid synthesis pathway.
Cat. No.: HY-E71705
Target:
Research Areas:
3-Hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59) is responsible for the dehydration step of the dissociated (type II) fatty-acid biosynthesis system that occurs in plants and bacteria.
Cat. No.: HY-174263
PaFabV-IN-1 (Compound 3e) is a selective Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (PaFabV) inhibitor with an IC50 value of 0.25 μM. PaFabV-IN-1 is promising for research of infections caused by P. aeruginosa and other Gram-negative bacteria .
Cat. No.: HY-151941
CAS No.: 3037822-97-9
MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM .
Cat. No.: HY-160679
CAS No.: 1071966-17-0
BaENR-IN-1 (Compound 5) is an inhibitor of Enoyl-Acyl Carrier Protein Reductase (ENR) (IC50= 7.7 μM). BaENR-IN-1 blocks the synthesis of fatty acids essential for bacterial growth by inhibiting the bacterial enzyme ENR. BaENR-IN-1 shows activity against bacteria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
