MtInhA-IN-1
MtInhA-IN-1 is a selective and orally active Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhibitor with an IC50 of 0.23 μM. MtInhA-IN-1 potently against M. tuberculosis H37Rv strain with a MIC value of 0.4 μM.
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- CAS No.: 3037822-97-9
- Formule: C21H22BrN3
- Masse moléculaire:396.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
IC50: 0.23 μM (Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA))[1]
MIC: 0.4 μM (M. tuberculosis H37Rv strain), 0.1 μM (M. tuberculosis strains PT2), 0.2 μM (M. tuberculosis strains PT12), and 0.1 μM (M. tuberculosis strains PT20)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | CC50 |
>20 μM
Compound: 19k
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 36435016] |
| HepG2 | CC50 |
18.3 μM
Compound: 19k
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay
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[PMID: 36435016] |
| Vero | CC50 |
>20 μM
Compound: 19k
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
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[PMID: 36435016] |
| Vero | CC50 |
12.2 μM
Compound: 19k
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Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 72 hrs by neutral red uptake assay
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[PMID: 36435016] |
In Vitro
MtInhA-IN-1 (compound 19k) shows inhibitory activity against a panel of multidrug-resistant M. tuberculosis strains, M. tuberculosis strains PT2, PT12, and PT20. The MIC values of 0.1 μM, 0.2 μM, and 0.1 μM for PT2, PT12, and PT20, respectively. In addition, MtInhA-IN-1 has low cytotoxicity against HepG2 and Vero cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:M. tuberculosis-infected mice [1]
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Dosage:300 μM/kg and 450 μM/kg
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Administration:Oral administration; daily; for 14 days
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Result:Reduced the growth of bacilli in the lungs of mice.
Chemical Information
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CAS No. 3037822-97-9
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Masse moléculaire 396.32
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Formule C21H22BrN3
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SMILES
CC1=NC2=C(C(NC3=CC=C(C=C3)N4CCCCC4)=C1)C=C(C=C2)Br
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MtInhA-IN-1 Related Classifications
HY-151941 Related Classifications
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