112710-84-6
Chemical Structure
UDP-3-O-acyl-GlcNAc Tris
Synonym(s): UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris
- CAS No.: 112710-84-6
- Formula:C35H64N4O22P2
- Molecular Weight:954.84
IUPAC Name: 3-(ethoxy-d5)-4-hydroxybenzaldehyde
InChIKey: FPGDONAZDJAUGH-WGNXMJDASA-N
SMILES: CC(N[C@@H]1[C@@H](OC(C[C@H](O)CCCCCCCCCCC)=O)[C@H](O)[C@@H](CO)O[C@@H]1OP(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@@](N3C=CC(NC3=O)=O)([H])O2)(O)=O)(O)=O)=O.OCC(CO)(N)CO
Biological Activity: UDP-3-O-acyl-GlcNAc Tris (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris) serves as a deacetylation substrate and biosynthetic intermediate in the biosynthetic pathways of lipid A and Kdo2-lipid A in Escherichia coli. UDP-3-O-acyl-GlcNAc Tris undergoes enzymatic deacetylation via LpxC to produce UDP-3-O-[(R)-3-hydroxymyristoyl]glucosamine and release acetate. UDP-3-O-acyl-GlcNAc Tris accumulates in Escherichia coli extracts in the absence of [(R)-3-hydroxymyristoyl]-acyl carrier protein. UDP-3-O-acyl-GlcNAc Tris can be used in studies related to Gram-negative shock[1][2].
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UDP-3-O-acyl-GlcNAc Tris | UDP-3-O-acyl-GlcNAc Tris (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris) serves as a deacetylation substrate and biosynthetic intermediate in the biosynthetic pathways of lipid A and Kdo2-lipid A in Escherichia coli. UDP-3-O-acyl-GlcNAc Tris undergoes enzymatic deacetylation via LpxC to produce UDP-3-O-[(R)-3-hydroxymyristoyl]glucosamine and release acetate. UDP-3-O-acyl-GlcNAc Tris accumulates in Escherichia coli extracts in the absence of [(R)-3-hydroxymyristoyl]-acyl carrier protein. UDP-3-O-acyl-GlcNAc Tris can be used in studies related to Gram-negative shock. | |||||||||||||||||||||
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References
- [1]. Anderson MS, et al. Biosynthesis of lipid A in Escherichia coli: identification of UDP-3-O-[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine as a precursor of UDP-N2,O3-bis[(R)-3-hydroxymyristoyl]-alpha-D-glucosamine. Biochemistry. 1988;27(6):1908-1917. [Content Brief]
- [2]. Opiyo SO, et al. Evolution of the Kdo2-lipid A biosynthesis in bacteria. BMC Evol Biol. 2010;10:362. Published 2010 Nov 24. [Content Brief]
