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Pathways Recommended:	PI3K/Akt/mTOR

Results for "

Akt 2 kinase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (14) AMPK (2) Apoptosis (2) Autophagy (6) Isotope-Labeled Compounds (1) PKC (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) ROCK (2) Ser/Thr Protease (1)
By Research Areas:	Cancer (15)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Targets Recommended: Akt

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15431

Capivasertib Maximum Cited Publications 81 Publications Verification AZD5363	Akt Autophagy	Cancer
Capivasertib (AZD5363) is an orally active and potent *pan-AKT* kinase inhibitor with IC₅₀ of 3, 7 and 7 nM for *Akt1,Akt2* and *Akt3*, respectively.

HY-15727

Afuresertib 15+ Cited Publications GSK2110183; LAE002	Akt PKC ROCK	Cancer
Afuresertib (GSK2110183) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3, respectively .

HY-10249

GSK-690693 40+ Cited Publications	Akt AMPK Autophagy	Cancer
GSK-690693 is an ATP-competitive *pan-Akt* inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for *Akt1, Akt2* and *Akt3, respectively. GSK-690693 is also an AMPK* inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .

HY-13260

CCT128930 5+ Cited Publications	Akt Autophagy Apoptosis	Cancer
CCT128930 is a ATP-competitive and selective inhibitor of *AKT* (IC₅₀=6 nM for AKT2). CCT128930 has 28-fold selectivity over the closely related PKA kinase (IC₅₀=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC₅₀=120 nM). Antitumor activity.

HY-15727A

Afuresertib hydrochloride 15+ Cited Publications GSK2110183 hydrochloride; LAE002 hydrochloride	Akt PKC ROCK	Cancer
Afuresertib hydrochloride (GSK 2110183 hydrochloride) is an orally bioavailable, selective, ATP-competitive and potent pan-Akt kinase inhibitor with K_is of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively .

HY-137458

Vevorisertib 1 Publications Verification ARQ 751	Akt Ser/Thr Protease	Cancer
Vevorisertib (ARQ 751) is an orally active, potent and selective *pan-AKT* serine/threonine kinase inhibitor against *AKT1* (IC₅₀=0.55 nM), *AKT2* (IC₅₀=0.81 nM), and *AKT3* (IC₅₀=1.31 nM). Vevorisertib, as a single agent or in combination with other anti-cancer agents, can be used for the research of solid tumors with PIK3CA / AKT / PTEN mutations .

HY-N2902

Artocarpin	Reactive Oxygen Species (ROS)	Cancer
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, *AktS473, p53, *Akt 1 kinase and Akt 2 kinase**. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

HY-126257

AKT-IN-3	Akt Apoptosis	Cancer
AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking *Akt* inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells .

HY-15431R

Capivasertib (Standard) AZD5363 (Standard)	Akt Autophagy Reference Standards	Cancer
Capivasertib (Standard) is the analytical standard of Capivasertib. This product is intended for research and analytical applications. Capivasertib (AZD5363) is an orally active and potent pan-AKT kinase inhibitor with IC50 of 3, 7 and 7 nM for Akt1,Akt2 and Akt3, respectively.

HY-E70791

Biotin-AKT2 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT2 Recombinant Human Active Protein Kinase is obtained by expressing AKT2 proteins and is biotinylated .

HY-E70786

**AKT1 E17K Recombinant Human Active Protein Kinase**	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. AKT1 E17K is a mutant of AKT1. AKT1 E17K Recombinant Human Active Protein Kinase is obtained by expressing AKT1 E17K proteins .

HY-E70790

Biotin-AKT1 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT1 Recombinant Human Active Protein Kinase is obtained by expressing AKT1 proteins and is biotinylated .

HY-15431S

Capivasertib-d4 AZD5363-d₄	Isotope-Labeled Compounds Autophagy Akt	Cancer
Capivasertib-d₄ (AZd₅363-d₄) is the deuterium labeled Capivasertib (HY-15431). Capivasertib (AZD5363) is an orally active and potent *pan-AKT* kinase inhibitor with IC₅₀ of 3, 7 and 7 nM for *Akt1,Akt2* and *Akt3*, respectively.

HY-E70792

Biotin-AKT3 Recombinant Human Active Protein Kinase	Akt	Cancer
AKT is the oncogenic protein kinase that regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. Mammalian cells are characterized by the expression of three different Akt isoforms, Akt1, Akt2, and Akt3. Biotin-AKT3 Recombinant Human Active Protein Kinase is obtained by expressing AKT3 proteins and is biotinylated .

HY-10249R

GSK-690693 (Standard)	Reference Standards Akt AMPK Autophagy	Cancer
GSK-690693 (Standard) is the analytical standard of GSK-690693 (HY-10249). This product is intended for research and analytical applications. GSK-690693 is an ATP-competitive pan-Akt inhibitor with IC₅₀s of 2 nM, 13 nM, 9 nM for Akt1, Akt2 and Akt3, respectively. GSK-690693 is also an AMPK inhibitor, affects Unc-51-like autophagy activating kinase 1 (ULK1) activity and robustly inhibits STING-dependent IRF3 activation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2902

Artocarpin	Structural Classification Flavonols Flavonoids Plants Moraceae Source Classification	Reactive Oxygen Species (ROS)
Artocarpin is an orally active apoptosis inducer. Artocarpin targets NF-κB, Erk1/2, p38 MAPK, *AktS473, p53, *Akt 1 kinase and Akt 2 kinase**. Artocarpin induces reactive oxygen species (ROS) production, mediates p53-dependent and p53-independent apoptotic signaling pathways, induces G1-phase cell cycle arrest, and triggers autophagic cell death. Artocarpin exerts cytotoxic and bactericidal effects on cancer cells, reduces bacterial load, and exhibits anti-inflammatory, analgesic and anti-angiogenic activities .

Species:	Human (4) Mouse (1)
Tag:	His (4) Myc (1) GST (4)
Source:	sf9 insect cells (1) Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702854

	AKT2 Protein, Mouse (His, Myc) Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta	Mouse	E. coli
	AKT2 Protein, Mouse (His, Myc) is the recombinant mouse-derived AKT2, expressed by E. coli, with N-10*His, C-Myc labeled tag.

HY-P702632

	AKT2 Protein, Human (Active, sf9, GST) Akt2; v-Akt murine thymoma viral oncogene homolog 2; PKBB; PRKBB; PKBBETA; RAC-BETA; Akt2 kinase; rac protein kinase beta; Murine thymoma viral (v-Akt) homolog-2; EC 2.7.11.1; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; PKB beta	Human	Sf9 insect cells
	The AKT2 protein is a serine/threonine protein kinase in the AKT family that is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage. AKT2 Protein, Human (Active, sf9, GST) is the recombinant human-derived AKT2, expressed by Sf9 insect cells, with GST labeled tag. The total length of AKT2 Protein, Human (Active, sf9, GST) is 480 a.a..

HY-P705728

	AKT2 Protein, Human (Active, E17K, sf9, His-GST) Akt2; v-Akt murine thymoma viral oncogene homolog 2; PKBB; PRKBB; PKBBETA; RAC-BETA; Akt2 kinase; rac protein kinase beta; Murine thymoma viral (v-Akt) homolog-2; EC 2.7.11.1; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; PKB beta	Human	sf9 insect cells

HY-P74420

	AKT2 Protein, Human (sf9, His-GST) RAC-beta serine/threonine-protein kinase; PKB beta; Akt2	Human	Sf9 insect cells
	The AKT2 protein is a serine/threonine protein kinase in the AKT family that is critical for metabolism, proliferation, survival, growth, and angiogenesis. It phosphorylates more than 100 substrates, coordinates insulin-induced SLC2A4/GLUT4 translocation, affects glucose uptake, and controls glycogen storage. AKT2 Protein, Human (sf9, His-GST) is the recombinant human-derived AKT2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag.

HY-P706017

	AKT2 Protein, Human (Active, 362a.a, sf9, His-GST) RAC-beta serine/threonine-protein kinase; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC protein kinase beta; RAC-PK-beta	Human	Sf9 insect cells

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Cat. No.	Product Name	Chemical Structure

HY-15431S

Capivasertib-d4
Capivasertib-d₄ (AZd₅363-d₄) is the deuterium labeled Capivasertib (HY-15431). Capivasertib (AZD5363) is an orally active and potent *pan-AKT* kinase inhibitor with IC₅₀ of 3, 7 and 7 nM for *Akt1,Akt2* and *Akt3*, respectively.

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Akt 2 kinase

Inhibitors & Agonists

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
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