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Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

BEAS-2b cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Akt (4) AMPK (1) Apoptosis (10) Arp2/3 Complex (1) Bacterial (4) CDK (2) COX (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (1) Drug Derivative (3) EGFR (2) Endogenous Metabolite (2) Environmental Pollutants (1) Epigenetic Reader Domain (1) ERK (1) Ferroptosis (1) FOXO (1) Free Fatty Acid Receptor (2) Fungal (2) G-quadruplex (1) Glycosidase (2) GPR68 (1) Histone Methyltransferase (2) HSP (1) HyT (2) Influenza Virus (1) Interleukin Related (6) JNK (2) Keap1-Nrf2 (3) MDM-2/p53 (2) Mitochondrial Metabolism (1) mTOR (1) NF-κB (3) NO Synthase (1) p38 MAPK (2) Penicillin-binding protein (PBP) (1) PERK (1) Phosphodiesterase (PDE) (1) PI3K (2) Quinone Reductase (1) Reactive Oxygen Species (ROS) (3) Reference Standards (2) SARS-CoV (3) STAT (4) TGF-β Receptor (1) TNF Receptor (2) TrxR (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (1) Infection (10) Inflammation/Immunology (15) Metabolic Disease (3) Neurological Disease (6)

By Targets:

Adrenergic Receptor (1)

Akt (4)

AMPK (1)

Apoptosis (10)

Arp2/3 Complex (1)

Bacterial (4)

CDK (2)

COX (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (1)

Drug Derivative (3)

EGFR (2)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Epigenetic Reader Domain (1)

ERK (1)

Ferroptosis (1)

FOXO (1)

Free Fatty Acid Receptor (2)

Fungal (2)

G-quadruplex (1)

Glycosidase (2)

GPR68 (1)

Histone Methyltransferase (2)

HSP (1)

HyT (2)

Influenza Virus (1)

Interleukin Related (6)

JNK (2)

Keap1-Nrf2 (3)

MDM-2/p53 (2)

Mitochondrial Metabolism (1)

mTOR (1)

NF-κB (3)

NO Synthase (1)

p38 MAPK (2)

Penicillin-binding protein (PBP) (1)

PERK (1)

Phosphodiesterase (PDE) (1)

PI3K (2)

Quinone Reductase (1)

Reactive Oxygen Species (ROS) (3)

Reference Standards (2)

SARS-CoV (3)

STAT (4)

TGF-β Receptor (1)

TNF Receptor (2)

TrxR (1)

By Research Areas:

Cancer (13)

Cardiovascular Disease (1)

Infection (10)

Inflammation/Immunology (15)

Metabolic Disease (3)

Neurological Disease (6)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101563

GSK3326595 Maximum Cited Publications 31 Publications Verification EPZ015938	Histone Methyltransferase SARS-CoV MDM-2/p53 CDK Apoptosis	Infection Cancer
GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .

HY-W011303

Phytosphingosine 4 Publications Verification 4-Hydroxysphinganine	Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC₅₀ value of 33.4 μM and can be used in the study of type II diabetes .

HY-Y1366

Hydroxyacetone	Mitochondrial Metabolism Reactive Oxygen Species (ROS) Arp2/3 Complex Apoptosis	Inflammation/Immunology
Hydroxyacetone is a toxic compound. Hydroxyacetone can be isolated from e-cigarette aerosols. Hydroxyacetone reduces the activity of cellular Mitochondrial reductase (with an IC₅₀ of 5.53 mg/mL for mitochondrial reductase in BEAS-2B cells) and increases ROS levels. Hydroxyacetone induces mitochondrial stress and oxidative damage. Hydroxyacetone induces destabilization of F-actin. At high concentrations, Hydroxyacetone promotes cell rounding and Apoptotic body formation. Hydroxyacetone exerts toxic effects on cells including airway epithelial cells and possesses respiratory toxicity potential .\n

HY-N2440

Gypenoside A 1 Publications Verification	Interleukin Related Reactive Oxygen Species (ROS) AMPK FOXO COX Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Gypenoside A is an orally active triterpenoid compound that can be isolated from Gynostemma pentaphyllum. Gypenoside A has anti-inflammatory and antioxidant activities. Gypenoside A also has a certain protective effect on cardiomyocytes and can inhibit apoptosis. Gypenoside A can be used in the research of cardiovascular diseases and inflammation-related diseases .

HY-P991280

BMS-981164	Interleukin Related	Inflammation/Immunology
BMS-981164 is a human anti-IL31 IgG1-κ monoclonal antibody. BMS-981164 effectively inhibits the IL-31 signaling pathway. The isotype control of BMS-981164 can be referenced to Human IgG1 kappa, Isotype Control (HY-P99001). BMS-981164 is applicable to research related to atopic dermatitis .

HY-N0412

Sesamoside	PERK JNK TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain .

HY-W016969

2-Undecanone	Environmental Pollutants Bacterial Interleukin Related Keap1-Nrf2 NF-κB	Infection Cancer
2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections .

HY-N2000

Bellidifolin 1 Publications Verification	STAT PI3K mTOR Akt	Neurological Disease Inflammation/Immunology Cancer
Bellidifolin is an orally active compound with antiproliferative, anti-inflammatory and antioxidant properties. Bellidifolin modulates key signaling pathways including STAT3, PI3K-Akt, mTOR and BRD4, and inhibits the viral protein R (Vpr). Bellidifolin induces cell cycle arrest and apoptosis, exerts significant antifibrotic effects, and protects the heart, liver and nervous system. Bellidifolin is applicable to the research of various diseases such as lung cancer, non-alcoholic fatty liver disease, myocardial hypertrophy and ischemic cranial nerve injury .

HY-148092

PM-43I	STAT	Inflammation/Immunology Cancer
PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research ^[1].

HY-114732

Procaterol	Adrenergic Receptor	Others
Procaterol is an oral selective β2 adrenergic receptor agonist. Procaterol inhibits eosinophil migration and the release of eosinophil chemotactic factor from BEAS-2B cells through a cyclic AMP-dependent mechanism. Procaterol has a large dose difference existing between the bronchodilator effect and the anabolic effect in rat, can be used for asthma research in athletes .

HY-162852

OAF89	G-quadruplex	Cancer
OAF89 is a small molecule that interacts with G-Quadruplexes (G4s) and dsDNA with an IC₅₀ of 1.07 μM in normal lung epithelial cells BEAS-2B .

HY-P5829A

CRAMP (140-173) (mouse) TFA	Bacterial	Infection
CRAMP (140-173) (mouse) TFA is a ortholog of human LL-37 antimicrobial peptide. CRAMP (140-173) (mouse) TFA inhibits LPS (HY-D1056)-induced responses, and can not colocalized with TLR3 in BEAS-2B cells .

HY-118829

3,4-Methylenedioxy PV9 hydrochloride	Drug Derivative	Neurological Disease
3,4-Methylenedioxy PV9 hydrochloride is a drug derivative. 3,4-Methylenedioxy PV9 hydrochloride shows toxicity against BEAS-2B, human aortic endothelia, HASM, SK-N-SH, A172, HepG2, MKN45, and DLD1cells (LC₅₀=12.8-67.5 μM) .

HY-168492

TrxR/EGFR-IN-1	Ferroptosis EGFR TrxR Apoptosis	Cancer
TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer .

HY-W011303R

Phytosphingosine (Standard) 4-Hydroxysphinganine (Standard)	Reference Standards Apoptosis Endogenous Metabolite Fungal Free Fatty Acid Receptor	Infection Metabolic Disease Inflammation/Immunology Cancer
Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].

HY-173411

DNJ-20	Glycosidase SARS-CoV	Infection Inflammation/Immunology
DNJ-20 is an α-glucosidase inhibitor (IC₅₀: 55.3 μg/mL). DNJ-20 has broad-spectrum anti-SARS-CoV-2 activity. DNJ-20 inhibits the correct processing of viral glycoproteins by interfering with the endoplasmic reticulum-associated glycoprotein folding process (ERQC), thereby blocking the formation and infection of viral particles. DNJ-20 has IC₅₀ values up to 1.49 uM against several SARS-CoV-2 variants, as well as HCoV-229E and HCoV-0C43。DNJ-20 can be used for pan-coronavirus research .

HY-172135

PDE4-IN-26	p38 MAPK Phosphodiesterase (PDE)	Inflammation/Immunology
PDE4-IN-26 (Compound A5) is an orally active and highly selective PDE4 inhibitor. PDE4-IN-26 has anti-inflammatory activity and can inhibit the phosphorylation of p38 MAPK. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 can improve pulmonary inflammation, injury and fibrosis, promote sputum secretion and relieve cough in mice. PDE4-IN-26 can be used for the research of lung injury-related diseases .

HY-P10854

TAT-N15	NF-κB Interleukin Related STAT Akt	Neurological Disease Inflammation/Immunology
TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke .

HY-125995

NFE2L2 activator 3	Keap1-Nrf2 Quinone Reductase	Inflammation/Immunology
NFE2L2 activator 3 (Compound 3) is a NFE2L2/NRF2 activator. NFE2L2 activator 3 specifically activates the NAD(P)H:quinone oxidoreductase (NQO1) enzyme, with its EC₅₀ < 1 nM. NFE2L2 activator 3 can be used for research on respiratory system diseases such as chronic obstructive pulmonary disease .

HY-182796

JNK1 degrader-1	HyT JNK	Cancer
JNK1 degrader-1 is a JNK1 HyT degrader. JNK1 degrader-1 can induce JNK1 degradation through the HyT-mediated ubiquitin-proteasome system and autophagy-lysosome pathway. JNK1 degrader-1 inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT). JNK1 degrader-1 can be used for research on fibrotic diseases and cancer metastasis. (Pink: JNK1 ligand (HY-183006); Blue: Hyt hydrophobic group (HY-W037848); Black: Linker (HY-B1008)) .

HY-182898

Gal-dMor-Gem	Apoptosis Glycosidase	Inflammation/Immunology
Gal-dMor-Gem is a selective senescent cell scavenger, Apoptosis inducer, and a prodrug of Gemcitabine (HY-17026). Gal-dMor-Gem releases Gemcitabine upon activation by Esterases and β-gal. Gal-dMor-Gem reduces SA-β-gal, preferentially induces apoptosis in senescent cells, regulates apoptosis-related proteins, accumulates in senescent tissues, and ameliorates senescence-related organ phenotypes. Gal-dMor-Gem is applicable to research on chemotherapy-induced senescence .

HY-183258

TGFβ1-IN-5	TGF-β Receptor	Neurological Disease Cancer
TGFβ1-IN-5 is a TGF-β1 inhibitor with blood-brain barrier permeability. TGFβ1-IN-5 reduces extracellular TGF-β1 levels in glioblastoma cells. TGFβ1-IN-5 exerts antiproliferative, antimigratory and clonogenic inhibitory effects in glioblastoma cells while maintaining the viability of non-cancerous cells. TGFβ1-IN-5 can be used for the research of glioblastoma .

HY-181672

PI3K/AKT/ERK/CREB activator 1	PI3K Akt ERK Epigenetic Reader Domain	Neurological Disease
PI3K/AKT/ERK/CREB activator 1 is an orally active PI3K/AKT/ERK/CREB pathway activator. PI3K/AKT/ERK/CREB activator 1 maintains neuronal survival and function, promotes neuronal proliferation, restores the viability of damaged neurons, and facilitates synapse formation. PI3K/AKT/ERK/CREB activator 1 alleviates neuroinflammation by reducing the levels of pro-inflammatory cytokines, preserves synaptic ultrastructure and restores spatial memory in Alzheimer's disease models. PI3K/AKT/ERK/CREB activator 1 can be used in research related to Alzheimer's disease .

HY-N18053

Anabsinthin	Drug Derivative Bacterial NF-κB NO Synthase	Infection
Anabsinthin is a dimeric sesquiterpene lactone. Anabsinthin can be found in Artemisia absinthium L. (wormwood). Anabsinthin modulates intracellular calcium levels, mediates anti-inflammatory and antioxidant effects. Anabsinthin inhibits Phorbol 12-myristate 13-acetate (HY-18739)-induced superoxide anion production, increased iNOS and MUC5AC protein expression, and IL-1β transcription upregulation. Anabsinthin can be used for the research of citrus canker .

HY-181485

GPR68 antagonist 1	GPR68 TNF Receptor Interleukin Related	Inflammation/Immunology
GPR68 antagonist 1 is a GPR68 antagonist with an IC₅₀ of 81 nM. GPR68 antagonist 1 inhibits the mouse GPR68-mediated cAMP signaling pathway with an IC₅₀ of 179 nM. GPR68 antagonist 1 alleviates disease symptoms in a dextran sulfate sodium (DSS) (HY-116282C)-induced mouse model of inflammatory bowel disease. GPR68 antagonist 1 is applicable to research related to inflammatory bowel disease .

HY-182288

YN11	STAT Apoptosis	Cancer
YN11 is a STAT3 inhibitor (K_d=11.9 μM). YN11 directly binds to the SH2 domain of STAT3, inhibits the phosphorylation of STAT3, and reduces the expression of downstream target proteins. YN11 induces cell cycle arrest, promotes apoptosis, and inhibits cell invasion and migration in prostate cancer cells. YN11 suppresses tumor growth in a prostate cancer xenograft mouse model. YN11 does not cause significant body weight loss or obvious histopathological changes in major organs in xenograft mice. YN11 is applicable to relevant research on prostate cancer .

HY-101563R

GSK3326595 (Standard) EPZ015938 (Standard)	Histone Methyltransferase Reference Standards SARS-CoV MDM-2/p53 CDK Apoptosis	Infection Cancer
GSK3326595 (Standard) is the analytical standard of GSK3326595 (HY-101563). This product is intended for research and analytical applications. GSK3326595 is a protein arginine methyltransferase 5 (PRMT5) inhibitor. GSK3326595 decreases SARS-CoV-2 infection, inhibits cancer cell proliferation and induces pro-inflammatory macrophage polarization and increases hepatic triglyceride levels without affecting atherosclerosis. GSK3326595 can be used for research of relapsed/refractory mantle cell lymphoma .

HY-181885

Antiviral agent 80	Influenza Virus Drug Derivative	Infection
Antiviral agent 80 is a conjugate of Zanamivir (HY-13210) and Amantadine (HY-13317), acting as a dual inhibitor of influenza virus M2 ion channel/neuraminidase (NA). Antiviral agent 80 exhibits potent inhibitory activity against both wild-type and drug-resistant influenza neuraminidase mutants, with an IC₅₀ value range of 1.50 nM to 120.4 nM. Antiviral agent 80 can be used in influenza-related research .

HY-183277

EGFR-IN-209	EGFR p38 MAPK Akt Apoptosis	Cancer
EGFR-IN-209 (Compound 6g) is an orally active, selective EGFR ^{Del19/T790M/C797S} inhibitor with an IC₅₀ of 0.056 μM. EGFR-IN-209 blocks the phosphorylation of EGFR and its downstream effector molecules (pMAPK, pAKT). EGFR-IN-209 induces Apoptosis. EGFR-IN-209 exhibits antitumor activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer. EGFR-IN-209 can be used in research related to non-small cell lung cancer .

HY-181907

NBE5	HyT Keap1-Nrf2 HSP	Inflammation/Immunology
NBE5 is an orally active hydrophobic tag-targeting (Hyt) degrader (HyTTD) that targets Keap1. NBE5 mimics protein misfolding and recruits the molecular chaperone Hsp90, while achieving targeted degradation of Keap1 through both the ubiquitin-proteasome system and the autophagy-lysosome system. Consequently, NBE5 relieves the inhibition of the transcription factor Nrf2 by Keap1, potently activates the Nrf2-mediated endogenous antioxidant pathway, and upregulates the expression of downstream antioxidant proteins such as HO-1 and GCLM. NBE5 effectively alleviates oxidative stress and inflammatory damage, and exhibits excellent in vivo activity in a mouse model of acute colitis induced by DSS (HY-116282C) . NBE5 consists of a hydrophobic tag (HY-W022007), a Keap1-Nrf2 ligand (HY-14909), and a linker (HY-W014831).

HY-183291

Antibacterial agent 343	Bacterial DNA/RNA Synthesis DNA Alkylator/Crosslinker Reactive Oxygen Species (ROS) Penicillin-binding protein (PBP)	Infection
Antibacterial agent 343 (Compound 47) is an Antibacterial agent. Antibacterial agent 343 binds to the allosteric site of PBP2a to open its active site. Antibacterial agent 343 disrupts bacterial cell membranes, leading to protein leakage. Antibacterial agent 343 interacts with DNA and inhibits replication and transcription. Antibacterial agent 343 induces ROS accumulation. Antibacterial agent 343 exhibits antibacterial activity against MRSA, Staphylococcus aureus, and Enterococcus faecalis. Antibacterial agent 343 can be used for the research of methicillin-resistant Staphylococcus aureus infections .

Cat. No.	Product Name	Target	Research Area