TrxR/EGFR-IN-1
TrxR/EGFR-IN-1 (Compound L1Au2) is a TrxR/EGFR inhibitor. TrxR/EGFR-IN-1 is active against both Gefitinib (HY-50895)-sensitive and resistant lung cancers, effectively inhibiting tumor proliferation and promoting apoptosis. TrxR/EGFR-IN-1 promotes the degradation of GPX4 protein through autophagolysosomal and proteasomal pathways, leading to ferroptosis. In addition, TrxR/EGFR-IN-1 can induce endoplasmic reticulum stress and trigger immunogenic cell death. TrxR/EGFR-IN-1 can be used for the research of Gefitinib (HY-50895)-resistant lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3038386-42-1
- Formula: C24H24AuClFN6O2P
- Molecular Weight:710.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 3038386-42-1
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Molecular Weight 710.88
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Formula C24H24AuClFN6O2P
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SMILES
ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(OCC#C[Au][P]45CN6CN(CN(C6)C5)C4)C(OC)=C3)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TrxR/EGFR-IN-1 Related Classifications
HY-168492 Related Classifications
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