PM-43I
Based on 1 Customer Validation
PM-43I is a potent STAT6 inhibitor and can reduce STAT6 phosphorylation level. PM-43I can be used in allergic lung disease, allergic rhinitis, chronic pulmonary obstructive disease and cancer research[1].
For research use only. We do not sell to patients.
- Purity: 98.87%
- CAS No.: 1637532-77-4
- Formula: C38H50F2N3O10P
- Molecular Weight:777.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PM-43I (0.05-5 μM; 2 h) inhibits IL-4 stimulated phosphorylation of STAT6 in Beas-2B immortalized human airway cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Beas-2B immortalized human airway cells
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Concentration:0.05, 0.1, 0.5, 1, 2.5, 5 µM
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Incubation Time:2 h
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Result:Inhibited STAT6 phosphorylation level to 18%, 21% at 2.5 and 5 µM, respectively.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice injected with Ovalhumin/Alum[1]
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Dosage:5 μg per mouse
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Administration:Intranasal administration; 5 μg per mouse; every other day; 18 days
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Result:Showed no effect on the sensisization of peripheral spleenocytes to ovalbumin.
Chemical Information
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CAS No. 1637532-77-4
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Appearance Solid
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Molecular Weight 777.79
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Formula C38H50F2N3O10P
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Color White to off-white
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SMILES
CC(C)(C)C(OCOP(C(F)(C1=CC=C(C=C1)/C(C)=C/C(N[C@@H]2C(N(CCCC2)CC(N(C3=CC=CC=C3)C)=O)=O)=O)F)(OCOC(C(C)(C)C)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 35 mg/mL (45.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2857 mL | 6.4285 mL | 12.8569 mL | 32.1424 mL |
| 5 mM | 0.2571 mL | 1.2857 mL | 2.5714 mL | 6.4285 mL | |
| 10 mM | 0.1286 mL | 0.6428 mL | 1.2857 mL | 3.2142 mL | |
| 15 mM | 0.0857 mL | 0.4286 mL | 0.8571 mL | 2.1428 mL | |
| 20 mM | 0.0643 mL | 0.3214 mL | 0.6428 mL | 1.6071 mL | |
| 25 mM | 0.0514 mL | 0.2571 mL | 0.5143 mL | 1.2857 mL | |
| 30 mM | 0.0429 mL | 0.2143 mL | 0.4286 mL | 1.0714 mL | |
| 40 mM | 0.0321 mL | 0.1607 mL | 0.3214 mL | 0.8036 mL |
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