112-12-9
Chemical Structure
2-Undecanone
- CAS No.: 112-12-9
- Formula:C11H22O
- Molecular Weight:170.30
IUPAC Name: undecan-2-one
InChIKey: KYWIYKKSMDLRDC-UHFFFAOYSA-N
SMILES: CC(CCCCCCCCC)=O
Biological Activity: 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections[1][2][3].
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2-Undecanone | 99.91% | 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections. | ||||||||||||||||||||
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2-Undecanone (Standard) | ≥98% | 2-Undecanone (Standard) is the analytical standard of 2-Undecanone (HY-W016969). This product is intended for research and analytical applications. 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections. | ||||||||||||||||||||
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2-Undecanone-d5 | 2-Undecanone-d5 is the deuterium labeled 2-Undecanone (HY-W016969). 2-Undecanone is an orally active organic ketone. 2-Undecanone exerts antibacterial effects by inhibiting bacterial chaperone systems and interfering with the refolding of heat-inactivated proteins. 2-Undecanone also ameliorates asthmatic inflammation and airway remodeling by blocking the NF-κB pathway, and activates the Nrf2 pathway to reduce oxidative damage and prevent lung cancer induced by Benzo[a]pyrene (HY-107377). 2-Undecanone can be used in research related to cancer, asthma and infections. | |||||||||||||||||||||
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References
- [1]. Lou Y, et al. Houttuynia cordata Thunb. and its bioactive compound 2-undecanone significantly suppress benzo(a)pyrene-induced lung tumorigenesis by activating the Nrf2-HO-1/NQO-1 signaling pathway. J Exp Clin Cancer Res. 2019;38(1):242. Published 2019 Jun 7. [Content Brief]
- [2]. Melkina OE, et al. Ketones 2-heptanone, 2-nonanone, and 2-undecanone inhibit DnaK-dependent refolding of heat-inactivated bacterial luciferases in Escherichia coli cells lacking small chaperon IbpB. Appl Microbiol Biotechnol. 2017;101(14):5765-5771. [Content Brief]
- [3]. Song G, et al. 2-Undecanone alleviates asthma by inhibiting NF-κB pathway. Biochem Cell Biol. 2023;101(1):101-111. [Content Brief]
