117479-87-5
Chemical Structure
Sesamoside
- CAS No.: 117479-87-5
- Formula:C17H24O12
- Molecular Weight:420.37
IUPAC Name: methyl (1aR,1bS,2S,5aR,6R,6aS)-5a,6-dihydroxy-1a-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-1a,1b,2,5a,6,6a-hexahydrooxireno[2',3':4,5]cyclopenta[1,2-c]pyran-5-carboxylate
InChIKey: XZVXEPPPQBLGMQ-HISQCTEXSA-N
SMILES: O=C(OC)C1=CO[C@@H](O[C@@]2([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@@]3([H])[C@]1(O)[C@H](O)[C@H]4[C@]3(C)O4
Biological Activity: Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Sesamoside | 99.77% | Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates AKR1B1 expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sesamoside (Standard) | ≥98% | Sesamoside (Standard) is the analytical standard of Sesamoside. This product is intended for research and analytical applications. Sesamoside is a iridoid isolated from the aerial part of? Lamiophlomis rotata. Sesamoside has antiodant and antiglycation activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Song D, et al. The amelioration effect of sesamoside on inflammatory response in septic shock. BMC Immunol. 2025;26(1):15. Published 2025 Mar 6. [Content Brief]
- [2]. Song D, et al. The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology. Dose Response. 2024;22(3):15593258241282574. Published 2024 Sep 7. [Content Brief]
- [3]. Park KT, et al. Phlomidis Radix Extract Alleviates Paclitaxel-Induced Neuropathic Pain by Modulating Spinal TRPV1 in Mice. Plants (Basel). 2023 Nov 10;12(22):3819. [Content Brief]
- [4]. Fuji Y, et al. Chemical characterization and biological activity in young sesame leaves (Sesamum indicum L.) and changes in iridoid and polyphenol content at different growth stages. PLoS One. 2018;13(3):e0194449. Published 2018 Mar 27. [Content Brief]
Keywords
