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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
57 Results for "
CBR
" in MedChemExpress (MCE) Product Catalog:
Products (57)
57 Results for "CBR" in MCE Product Catalog:
34
34 Publications Verification
Synonyms: Rutoside; Quercetin 3-O-rutinoside
21
21 Cited Publications
Research Areas:
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC50 of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .
12
12 Cited Publications
Synonyms: Quercetin 3-O-glucuronide; Quercetin 3-glucuronide
Category:
Flavonols other families Flavonoids Phenols Polyphenols Plants Endogenous metabolite Disease Research Fields Cancer
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4
3
3 Cited Publications
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CBR-470-1 is an inhibitor of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2 activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP +-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .
1
1 Cited Publications
Synonyms: Rutoside (Standard); Quercetin 3-O-rutinoside (Standard)
Cat. No.: HY-W008137
CAS No.: 62802-38-4
Research Areas:
Hydroxy-PP-Me is a selective CBR1 inhibitor with an IC50 of 759 nM. Hydroxy-PP-Me can inhibit serum starvation-induced apoptosis. Hydroxy-PP-Me can enhance the cytotoxic effects of Daunorubicin (HY-13062A) and As2O3 on tumor cells. Hydroxy-PP-Me can be used in the research of cancer such as leukemia .
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CBR-470-2, a glycine-substituted analog, can activate NRF2 signaling. CBR-470-2 can be used for the research of modulation glycolysis .
Cat. No.: HY-157445
CAS No.: 891101-69-2
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CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC50 value of 0.034 μM .
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Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM .
Cat. No.: HY-135184
CAS No.: 922717-97-3
Synonyms: CBR-2092; TNP-2092
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Rifaquizinone (CBR-2092) is a Rifamycin-Quinolone Hybrid Antibiotic. Rifaquizinone inhibits wild-type S. aureus RNA polymerase with an IC50 of 34 nM. Rifaquizinone is effective against S. aureus infections, with MICs ranged from 0.008 to 0.5 μg/mL for 300 clinical isolates of staphylococci and streptococci .
Synonyms: 7-Monohydroxyethylrutoside
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Research Areas:
MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner .
Cat. No.: HY-117485
CAS No.: 1776931-05-5
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CBR-096-4 is a derivative of Itraconazole (HY-17514). CBR-096-4 is an orally active antifibrotic agent with no CYP3A4 inhibitory activity. CBR-096-4 inhibits the formation of matrix-secreting activated myofibroblasts (MFBs) from multiple tissue types. CBR-096-4 inhibits Hedgehog reporter activity (GLI-LUC), VEGF-dependent growth, and αSMA-LUC reporter activity. CBR-096-4 can be used for research of fibrosis .
Cat. No.: HY-151107
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CBR Agonist-2 is a CB1 agonist (CB1R; CB1 ligand) with an EC50 and a Ki of 960 nM and 970 nM, respectively. CBR Agonist-2 is a promising tool for investigating the involvement of hCB1R in disorders associated with the endocannabinoid system .
Cat. No.: HY-151105
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CBR Agonist-1 (27a-cis) is a cannabinoid receptor (CBR) agonist with the Ki values of 0.18 μM for CB1R and 1.22 μM for CB2R. CBR Agonist-1 (27a-cis) can be used in the study of endogenous cannabinoid system-related diseases .
Cat. No.: HY-RS18341
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Cbr1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cbr1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W744549
CAS No.: 116-58-5
Synonyms: 20β-DHF
Category:
Cat. No.: HY-157451
CAS No.: 1119826-35-5
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Research Areas:
CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research .
Cat. No.: HY-157447
CAS No.: 1798284-64-6
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CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
