1. NF-κB
  2. Keap1-Nrf2
  3. CBR-470-2

CBR-470-2 

Cat. No.: HY-134001
Handling Instructions

CBR-470-2, a glycine-substituted analog, and can activate NRF2 signaling. CBR-470-2 can be used for modulation glycolysis.

For research use only. We do not sell to patients.

CBR-470-2 Chemical Structure

CBR-470-2 Chemical Structure

CAS No. : 2416095-00-4

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Description

CBR-470-2, a glycine-substituted analog, and can activate NRF2 signaling. CBR-470-2 can be used for modulation glycolysis[1].

IC50 & Target

NRF2[1]

In Vitro

CBR-470-2 (1-10 μM; 24 h) increases transcript levels of the NRF2-responsive genes NQO1 and HMOX1 in epidermal keratinocytes and dermal fibroblasts[1].

In Vivo

CBR-470-2 (50 mg/kg; p.o. twice daily for 10 d) induces activation of NRF2 signaling in vivo[1].

Animal Model: Balb/C mice (5-week old) are exposed to UVB[1]
Dosage: 50 mg/kg
Administration: P.o. twice daily for 10 days
Result: Resulted in comparable beneficial effects on erythema histological scores and total wounded area.
Decreased epidermal thickness in response to UV exposure.
Molecular Weight

402.27

Formula

C₁₂H₁₃Cl₂NO₆S₂

CAS No.

2416095-00-4

SMILES

OC(CN[[email protected]@H](C1)[[email protected]@H](S(C2=CC=C(Cl)C(Cl)=C2)(=O)=O)CS1(=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CBR-470-2Keap1-Nrf2NRF2signalingmodulationglycolysisInhibitorinhibitorinhibit

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CBR-470-2
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