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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Candida albicans SC5314
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Candida albicans SC5314" in MCE Product Catalog:
Synonyms: JAU-6476
Target:
Fungal Cytochrome P450 Microtubule/Tubulin Mitochondrial Metabolism DNA/RNA Synthesis Apoptosis Fatty Acid Synthase (FASN)
Research Areas:
Prothioconazole is an orally active broad-spectrum fungicide. Prothioconazole weakly inhibits CaCYP51 activity in Candida albicans, with an apparent IC50 of approximately 120 μM. Prothioconazole disrupts Microtubule stability by reducing the acetylation level of α-tubulin. Prothioconazole induces Mitochondrial dysfunction, oxidative stress, DNA damage, and Apoptosis. Prothioconazole accumulates 14-methylated sterols and depletes ergosterol in cells, culture media, plants, and animals. Prothioconazole interferes with pyruvate metabolism and glycolysis/gluconeogenesis processes in mouse liver, downregulates Fasn mRNA expression, and induces hepatotoxicity and renal metabolic disorders. Prothioconazole reduces the fertility of female mice. Prothioconazole inhibits body weight gain and increases liver/kidney indices in mice. Prothioconazole can be used in studies related to candidiasis .
Cat. No.: HY-178732
CAS No.: 1463913-43-0
Research Areas:
AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis .
Cat. No.: HY-W1127089
CAS No.: 3075607-57-4
Target:
Research Areas:
Antifungal agent 136 is a CYP51 inhibitor and antifungal agent. Antifungal agent 136 downregulates the expression of interleukin-6 to alleviate inflammatory responses. Antifungal agent 136 exhibits activity against both drug-sensitive and drug-resistant Candida albicans strains. Antifungal agent 136 can be used in the research of fungal infections and inflammatory diseases .
Cat. No.: HY-184728
Antifungal agent-169 (compound 5p) is an antifungal agent that inhibits fluconazole (HY-B0101)-susceptible Candida albicans SC5314 with an MIC50 of 0.28 μM. Antifungal agent-169 reduces the expression levels of cAMP-PKA pathway-related genes including RAS1, EFG1, BCR1, ECE1 and HWP1 in Candida albicans. Antifungal agent-169 inhibits biofilm formation and hyphal growth of Candida albicans. Antifungal agent-169 can be used in studies related to Candida albicans infection .
Cat. No.: HY-E70241
CAS No.: 157786-88-4
Target:
Research Areas:
3-Hydroxypropionyl-CoA is a metabolic intermediate and enzyme substrate/product that functions in multiple metabolic pathways. 3-Hydroxypropionyl-CoA serves as a substrate for 3-Hydroxypropionyl-CoA dehydratase (HY-E71752), a product of 3-hydroxypropionyl-CoA synthetase, and a hydrolysis substrate for Ehd3p. 3-Hydroxypropionyl-CoA participates in autotrophic CO2 fixation, modified β-oxidation, and reverse hydration reactions. Accumulation of 3-Hydroxypropionyl-CoA inhibits fatty acid β-oxidation at the Fox2p site and induces metabolic toxicity. 3-Hydroxypropionyl-CoA can be used in studies of hematogenously disseminated candidiasis .
Cat. No.: HY-126443A
CAS No.: 1352296-65-1
Antifungal agent 173 is an orally active antifungal (fungal) agent. Antifungal agent 173 disrupts fungal cell membrane integrity, inhibits yeast-hypha transition in Candida species, and suppresses biofilms. Antifungal agent 173 prevents mouse mortality in a mouse model of systemic candidiasis and reduces tongue lesions in a mouse model of oropharyngeal candidiasis. Antifungal agent 173 is applicable to research related to candidiasis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
