3-Hydroxypropionyl-CoA
3-Hydroxypropionyl-CoA is a metabolic intermediate and enzyme substrate/product that functions in multiple metabolic pathways. 3-Hydroxypropionyl-CoA serves as a substrate for 3-Hydroxypropionyl-CoA dehydratase (HY-E71752), a product of 3-hydroxypropionyl-CoA synthetase, and a hydrolysis substrate for Ehd3p. 3-Hydroxypropionyl-CoA participates in autotrophic CO2 fixation, modified β-oxidation, and reverse hydration reactions. Accumulation of 3-Hydroxypropionyl-CoA inhibits fatty acid β-oxidation at the Fox2p site and induces metabolic toxicity. 3-Hydroxypropionyl-CoA can be used in studies of hematogenously disseminated candidiasis.
For research use only. We do not sell to patients.
- CAS No.: 157786-88-4
- Formula: C24H40N7O18P3S
- Molecular Weight:839.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Biological Activity
3-Hydroxypropionyl-CoA acts as a substrate for recombinant 3-Hydroxypropionyl-CoA dehydratase (HY-E71752) from Metallosphaera sedula, which catalyzes its dehydration to acryloyl-CoA with an apparent Km of 60 μM[1].
3-Hydroxypropionyl-CoA causes Candida albicans SC5314 cells to show complete growth inhibition on butyrate/propionate medium when accumulated (due to Ehd3p deletion), demonstrating that this metabolite potently and specifically inhibits fatty acid β-oxidation[2].
3-Hydroxypropanoyl-CoA is identified as a minor synthetic side product of 4-nitrobutyryl-CoA production and a degradation product of the human GCD-catalyzed oxidation of 4-nitrobutyryl-CoA, detected via mass spectrometry with distinct m/z values and intensities depending on the electron acceptor used[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 157786-88-4
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Molecular Weight 839.60
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Formula C24H40N7O18P3S
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SMILES
NC1=NC=NC2=C1N=CN2[C@H]3[C@H](O)[C@H](OP(O)(O)=O)[C@@H](COP(O)(OP(O)(OCC(C)([C@H](C(NCCC(NCCSC(CCO)=O)=O)=O)O)C)=O)=O)O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
3-Hydroxypropionyl-CoA Related Classifications
HY-E70241 Related Classifications
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- 3-Hydroxypropionyl-CoA
- 157786-88-4
- Endogenous Metabolite
- Fungal
- 3-hydroxypropionyl-CoA dehydratase
- fatty acid β-oxidation
- hematogenously disseminated candidiasis
- Candida albicans SC5314
- Ehd3p
- Fox2p
- acryloyl-CoA reductase
- Metallosphaera sedula
- autotrophic CO2 fixation
- 3-hydroxypropionyl-CoA synthetase
- Inhibitor
- inhibitor
- inhibit