Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
80 Results for "
Cholesterol biosynthesis
" in MedChemExpress (MCE) Product Catalog:
Products (80)
80 Results for "Cholesterol biosynthesis" in MCE Product Catalog:
10
Target:
Research Areas:
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol .
7
7 Cited Publications
Target:
Research Areas:
E 2012 is a potent gamma (γ) secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase (DHCR24) at the final step in the cholesterol biosynthesis. E 2012 aims at Alzheimer's disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat .
6
Category:
Target:
6
4
4 Cited Publications
Cat. No.: HY-B0444
CAS No.: 10347-81-6
Research Areas:
Maprotiline hydrochloride is a highly selective noradrenergic reuptake inhibitor that has strong antidepressant, antitumor and neuropathic pain-relieving effects with oral activity. Maprotiline hydrochloride induces cancer cell apoptosis by targeting the ERK signaling pathway and CRABP1 .
2
Target:
2
Category:
Target:
2
Target:
1
Target:
Research Areas:
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .
1
1 Cited Publications
Cat. No.: HY-164561
CAS No.: 1678515-93-9
Research Areas:
TASIN-30 is a selective EBP inhibitor with an EC50 of 0.097 μM. TASIN-30 blocks the production of 7-dehydrocholesterol (7-DHC) and downstream cholesterol biosynthesis processes. TASIN-30 depletes downstream sterols, disrupts the integrity of lipid rafts in tumor cells, accelerates intracellular cholesterol consumption, and inhibits tumor cell proliferation. TASIN-30 induces ferroptosis and apoptosis by reducing 7-DHC levels and increasing phospholipid peroxidation. TASIN-30 achieves tumor suppression in nude mice with osteosarcoma. TASIN-30 can be used in cancer-related research such as colorectal cancer and osteosarcoma .
1
Research Areas:
2,3-Oxidosqualene (Squalene oxide) is a sterol biosynthesis precursor intermediate.2,3-Oxidosqualene participates in cyclization pathways that form sterols and triterpenes, and contributes to introduction of their characteristic 3-hydroxyl group.2,3-Oxidosqualene forms metabolically from squalene in rat liver homogenates under sterol synthesis conditions.2,3-Oxidosqualene converts to sterols including cholesterol, lathosterol, and lanost-8-en-3β-ol in rat liver homogenates under anaerobic conditions .
1
1 Cited Publications
Synonyms: Antibiotic MB 530A; Lovastatin diol lactone
Target:
Research Areas:
Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
1
1 Cited Publications
Cat. No.: HY-N10549
CAS No.: 83088-28-2
1
1 Cited Publications
Synonyms: 5a-Cholest-8-en-3b-ol
Category:
Target:
Research Areas:
TASIN-1 is a selective inhibitor of truncated APC TR (adenomatous polyposis coli gene) that exerts cytotoxic effects by inhibiting cholesterol biosynthesis. TASIN-1 specifically targets colorectal cancer (CRC) cells carrying APC truncated mutations, while having no significant toxicity to wild-type APC cells. TASIN-1 exerts cytotoxic effects by targeting Emopamil binding protein (EBP) to inhibit cholesterol biosynthesis, triggering endoplasmic reticulum (ER) stress, reactive oxygen species (ROS) generation, and JNK-mediated apoptosis, and inhibiting Akt survival signaling. TASIN-1 can be used to prevent and intervene in APC mutant colorectal cancer .
Cat. No.: HY-N7392A
Synonyms: 3-Oxobutanoyl-coenzyme A sodium hydrate
Target:
Category:
Target:
Cat. No.: HY-150287A
Synonyms: ITS-X
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
