2,3-Oxidosqualene
Based on 1 publication(s) in Google Scholar
2,3-Oxidosqualene (Squalene oxide) is a sterol biosynthesis precursor intermediate.2,3-Oxidosqualene participates in cyclization pathways that form sterols and triterpenes, and contributes to introduction of their characteristic 3-hydroxyl group.2,3-Oxidosqualene forms metabolically from squalene in rat liver homogenates under sterol synthesis conditions.2,3-Oxidosqualene converts to sterols including cholesterol, lathosterol, and lanost-8-en-3β-ol in rat liver homogenates under anaerobic conditions.
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- Purity : 99.9%
- CAS No.: 7200-26-2
- 화학식: C30H50O
- 분자량:426.72
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보관:Shipping with dry ice
-80°C
Publications Citing Use of MedChemExpress (MCE) 2,3-Oxidosqualene
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
제품 설명
In Vitro
2,3-oxidosqualene (30 min; aerobic/anaerobic conditions) is synthesized from squalene in rat liver homogenates, and is efficiently converted to sterols (40% overall conversion under aerobic conditions, 80% per single enantiomer) with greater anaerobic conversion efficiency than squalene, confirming it as an intermediate in rat liver sterol biosynthesis[1].
2,3-oxidosqualene (anaerobic conditions) is converted by rat liver homogenates primarily to lanost-8-en-3β-ol, which can be further converted to cholesterol and cholest-7-en-3β-ol under aerobic conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 7200-26-2
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Appearance Oil
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분자량 426.72
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화학식 C30H50O
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Color Colorless to light yellow
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SMILES
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CCC1C(C)(O1)C
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Synonyms
Squalene oxide
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선적
Shipping with dry ice.
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보관
-80°C
Publications (1)
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Journal Impact Factor
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Most Recent
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J Bone Oncol
LL-37 inhibits osteosarcoma progression by suppressing SQLE-mediated cholesterol synthesis via the PTEN/AKT/mTOR pathway. [Abstract]2026 Jun 24:59:100779. PMID: 42388271
순도&문서
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Data Sheet (261 KB)
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SDS (392 KB)
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- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)