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Results for "

Diuresis

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (2) Aryl Hydrocarbon Receptor (1) Bacterial (1) Biochemical Assay Reagents (1) Calcium Channel (1) Carbonic Anhydrase (2) Chloride Channel (1) CRFR (2) Dopamine Receptor (1) Endogenous Metabolite (2) Endothelin Receptor (2) Guanylate Cyclase (1) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Na+/K+ ATPase (1) Natriuretic Peptide Receptor (NPR) (2) Neprilysin (2) Neurotensin Receptor (1) NF-κB (2) NO Synthase (1) Opioid Receptor (2) Potassium Channel (4) Prostaglandin Receptor (1) Reference Standards (4) Sodium Channel (3) Sodium Chloride Cotransporter (NCC) (1) Vasopressin Receptor (4) VEGFR (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (19) Endocrinology (6) Infection (3) Inflammation/Immunology (5) Metabolic Disease (11) Neurological Disease (7)

By Targets:

Adenosine Receptor (1)

Adrenergic Receptor (2)

Aryl Hydrocarbon Receptor (1)

Bacterial (1)

Biochemical Assay Reagents (1)

Calcium Channel (1)

Carbonic Anhydrase (2)

Chloride Channel (1)

CRFR (2)

Dopamine Receptor (1)

Endogenous Metabolite (2)

Endothelin Receptor (2)

Guanylate Cyclase (1)

HIF/HIF Prolyl-Hydroxylase (1)

Isotope-Labeled Compounds (1)

Na+/K+ ATPase (1)

Natriuretic Peptide Receptor (NPR) (2)

Neprilysin (2)

Neurotensin Receptor (1)

NF-κB (2)

NO Synthase (1)

Opioid Receptor (2)

Potassium Channel (4)

Prostaglandin Receptor (1)

Reference Standards (4)

Sodium Channel (3)

Sodium Chloride Cotransporter (NCC) (1)

Vasopressin Receptor (4)

VEGFR (1)

By Research Areas:

Cancer (2)

Cardiovascular Disease (19)

Endocrinology (6)

Infection (3)

Inflammation/Immunology (5)

Metabolic Disease (11)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0436

Engeletin 5+ Cited Publications	NF-κB	Infection Inflammation/Immunology
Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-A0080

Aminohippurate sodium 4 Publications Verification Sodium p-aminohippurate; p-Aminohippuric acid sodium salt	Biochemical Assay Reagents
Aminohippurate sodium is a renal tubular transport inhibitor and a substrate for organic anion transporters. Aminohippurate sodium inhibits renal tubular reabsorption of phosphate and promotes increased urinary phosphate excretion. Aminohippurate sodium inhibits renal tubular reabsorption of vitamin C as well as the transport of glucose .

HY-P990951

Vixticibart REGN-5381	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Vixticibart (REGN-5381) is a fully human IgG4 monoclonal antibody and NPR1 agonist that targets NPR1. Vixticibart stabilizes the receptor in an activated conformation by binding to the N-terminal domain of NPR1, and enhances the activity of endogenous ligands ANP and BNP without blocking ligand binding when these ligands are present. Vixticibart exerts vasodilatory and hypotensive effects by inducing cGMP production, preferentially dilating venous vessels to reduce systolic and venous pressure, but does not induce diuresis and may trigger a compensatory increase in heart rate. Vixticibart produces a synergistic hypotensive effect when combined with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and is currently mainly used in research related to heart failure and hypertension .

HY-P2469

Brain Natriuretic Peptide-45, mouse BNP-45, mouse	Natriuretic Peptide Receptor (NPR)	Cardiovascular Disease
Brain Natriuretic Peptide-45, mouse (BNP-45, mouse) is a 45-amino-acid peptide derived from the mouse BNP prohormone, which exhibits natriuretic, diuretic, and vasoactive effects. Brain Natriuretic Peptide-45, mouse contains all amino acid residues deemed critical for the biological activity of natriuretic peptides. Brain Natriuretic Peptide-45, mouse possesses hypotensive and diuretic activities .

HY-108868

Mersalyl Salirgan; Salurin; Salyrgan	HIF/HIF Prolyl-Hydroxylase VEGFR	Metabolic Disease
Mersalyl (Salirgan) is a potent vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) inducer. Mersalyl induces VEGF and ENO1 mRNA expression. Mersalyl shows diuresis effects .

HY-122560A

VU0134992 hydrochloride 4 Publications Verification	Potassium Channel	Cardiovascular Disease
VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC₅₀ of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC₅₀=9 µM) at -120 mV .

HY-122560

VU0134992 4 Publications Verification	Potassium Channel	Cardiovascular Disease
VU0134992 is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC₅₀ of 0.97 µM. VU0134992 is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC₅₀=9 µM) at -120 mV .

HY-15195

Avosentan Ro 67-0565; SPP-301	Endothelin Receptor	Cardiovascular Disease Endocrinology
Avosentan (Ro 67-0565; SPP-301) is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure .

HY-106616

Muzolimine BAY-g 2821; Edrul	Sodium Channel	Cardiovascular Disease
Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease .

HY-N2499

Dehydrotumulosic acid	Others	Metabolic Disease
Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-P1298A

Sauvagine TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine TFA, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine TFA is effective at releasing ACTH from rat pituitary cells. Sauvagine TFA possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-139037

8-Aminoguanine	Endogenous Metabolite	Metabolic Disease
8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-P1298

Sauvagine	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Sauvagine, a 40-amino-acid neuropeptide from the skin of the frog, is a mammalian CRF agonist. Sauvagine is effective at releasing ACTH from rat pituitary cells. Sauvagine possesses a number of pharmacological actions on diuresis, the cardiovascular system and endocrine glands .

HY-N8228

17-Hydroxyneomatrine	Bacterial	Infection Inflammation/Immunology Cancer
17-Hydroxyneomatrine, extracted from Sophora flavescens, can well inhibit the growth of human cervical carcinoma Hela cells, has the wide-range antibacterial, anti-allergy, anti-tumor, anti-arrhythmia, swelling-subsiding diuresis, immunizing, and biological regulation functions .

HY-124404

12(R)-HETE	Aryl Hydrocarbon Receptor Na+/K+ ATPase Prostaglandin Receptor	Inflammation/Immunology
12(R)-HETE is a CYP-dependent arachidonic acid metabolite that acts as a proinflammatory lipid mediator. 12 (R)-HETE widely exists in various tissues including the eye, skin and liver. In the cornea, 12(R)-HETE is metabolized via pathways such as β-oxidation into the precursor of 12(R)-HETrE. Without direct receptor binding, 12(R)-HETE indirectly activates AHR-mediated target gene transcription, while inhibiting the enzymatic activity of Na+,K+-ATPase and the intracellular calcium elevation induced by TP agonists. 12(R)-HETE also possesses multiple physiological effects such as chemotaxis, proangiogenesis, vasodilation, natriuresis, diuresis and intraocular pressure reduction, and can be widely used in studies related to psoriasis, inflammatory skin diseases and ocular inflammation .

HY-N9113

1,3,5,6-Tetrahydroxyxanthone	Others	Cardiovascular Disease
1,3,5,6-Tetrahydroxyxanthone is a natural xanthone that can be isolated from Garcinia achachairu Rusby (Clusiaceae) branches. 1,3,5,6-Tetrahydroxyxanthone induces diuresis and saluresis in normotensive and hypertensive rats .

HY-P11380

Capa-2	Neurotensin Receptor Calcium Channel NO Synthase Guanylate Cyclase	Neurological Disease Metabolic Disease
Capa-2 is a neuropeptide. Capa-2 activates calcium ion influx, stimulates the production of NO, activates soluble guanylate cyclase (sGC), increases intracellular cGMP, and drives ion and fluid secretion. Capa-2 can be used in studies of diuresis .

HY-19070

BRL-52656	Opioid Receptor	Cardiovascular Disease
BRL-52656 is a blood-brain barrier (BBB)-penetrable KOR receptor agonist that exhibits a biphasic effect. At low doses, BRL-52656 decreases blood pressure, whereas high doses have the opposite effect in spontaneously hypertensive rats. Additionally, BRL-52656 induces water diuresis by inhibiting the secretion of vasopressin (AVP) .

HY-W752502

Docarpamine	Dopamine Receptor Vasopressin Receptor Adrenergic Receptor	Cardiovascular Disease
Docarpamine is an orally active dopamine prodrug that can be hydroxylated in the small intestine and liver to form active dopamine. Docarpamine mainly activates D1-like receptors in peripheral blood vessels to lower blood pressure and heart rate in a state of spontaneous hypertension. Docarpamine exerts a pressor and tachycardic effect by activating D1-like receptors, vasopressin V1 receptors, and α-adrenergic receptors in normal blood pressure conditions. Docarpamine can be used for research on renal vascular dilation and diuresis .

HY-111961

Epitizide	Sodium Chloride Cotransporter (NCC)	Metabolic Disease
Epitizide, a benzothiadiazine, commonly found in combination Triamterene (HY-B0575), is used to produce diuresis .

HY-106616R

Muzolimine (Standard) BAY-g 2821 (Standard); Edrul (Standard)	Sodium Channel Reference Standards	Cardiovascular Disease
Muzolimine (Standard) is the analytical standard of Muzolimine. This product is intended for research and analytical applications. Muzolimine (BAY-g 282) is a slow and long lasting diuresis agent. Muzolimine produces a diuresis in the loop of Henle and also shows anti-hypertensive and natriuresis effects. Muzolimine can be used for the research of cardiovascular disease .

HY-N15269

Cyperol	Others	Others
Cyperol is a chemical component of the Nagarmotha (Cyperus rotundus). Nagarmotha possesses various pharmacological activities such as diuresis, digestion, menstruation, insect repellent, analgesia and anti-inflammatory .

HY-137364

Disulfamide	Carbonic Anhydrase	Cardiovascular Disease Metabolic Disease
Disulfamide, an orally active diuretic, is a carbonic anhydrase inhibitor with the IC₅₀ value of 0.07 μM. Disulfamide leads to diuresis by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in the proximal tubule .

HY-129557

A-49816	Vasopressin Receptor	Neurological Disease
A-49816 is an orally active diuretic that increases urine volume and sodium and chloride excretion. A-49816 at high doses (12.5, 15, and 20 mg) caused significant salt and chloride excretion and diuresis in experimental animals .

HY-111181

A 56234	Sodium Channel Potassium Channel	Metabolic Disease
A 56234 is an orally active benzisoxazole diuretic. A 56234 produces dose-dependent diuresis, sodium and chloride excretion, significantly increases potassium excretion, and also slightly increases calcium, magnesium, and total protein excretion. A 56234 has shown uricosuric effects in animal studies

HY-19063

SCH-34826	Neprilysin	Cardiovascular Disease Others
SCH-34826 is an orally active neutral metalloendopeptidase (NEP) inhibitor that inhibits NEP and reduces the degradation of ANF, thereby enhancing its antihypertensive and diuretic effects. SCH-34826 can be used in the research of cardiovascular and renal diseases .

HY-N0436R

Engeletin (Standard)	Reference Standards NF-κB	Infection Inflammation/Immunology
Engeletin (Standard) is the analytical standard of Engeletin. This product is intended for research and analytical applications. Engeletin is a flavanonol glycoside isolated from Smilax glabra Roxb. , inhibits NF-κB signaling-pathway activation, and possesses anti-inflammatory, analgesic, diuresis, detumescence, and antibiosis effects.

HY-133173

Niravoline RU51599	Vasopressin Receptor Opioid Receptor	Neurological Disease
Niravoline (RU51599) is an arginine vasopressin (AVP) release inhibitor and a selective kappa opioid receptor agonist. Niravoline has a pure water diuresis effect without associated electrolyte excretion. Niravoline can reduce brain oedema following transient forebrain ischaemia in rats .

HY-W771063

8-Aminoguanine-13C2,15N	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
8-Aminoguanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-124687

ROMK-IN-32	Potassium Channel	Cardiovascular Disease
ROMK-IN-32 is a renal outer medullary potassium channel (ROMK) inhibitor with an IC₅₀ of 35 nM. ROMK-IN-32 also inhibits hERG with an IC₅₀ of 22 μM .

HY-118233

Alilusem potassium M 17055	Chloride Channel	Neurological Disease
Alilusem potassium is a diuretic. In anesthetized dogs undergoing water diuresis, Alilusem potassium effectively decreased free water clearance and increased Na+ and Cl- levels in excreted urine. When combined with Furosemide (HY-B0135) or Hydrochlorothiazid, Alilusem potassium further inhibited free water clearance. Alilusem potassium inhibited the lumen-positive transepithelial voltage and lumen-to-cistern Cl- flux in isolated rabbit cortical thick ascending limbs of Henle .

HY-N2499R

Dehydrotumulosic acid (Standard)	Reference Standards Others	Metabolic Disease
Dehydrotumulosic acid (Standard) is the analytical standard of Dehydrotumulosic acid. This product is intended for research and analytical applications. Dehydrotumulosic acid is one of the effective constituents of Poria cocos. Poria cocos, a popular Chinese medicinal herb of fungal origin, has been included in many combinations with other CM herbs for its traditionally claimed activities of inducing diuresis, excreting dampness, invigorating the spleen and tranquilizing the mind and its modern pharmacological use of modulating the immune system of the body .

HY-117961

Candoxatrilat UK 73967	Neprilysin	Cardiovascular Disease Endocrinology
Candoxatrilat (UK 73967) is an orally active inhibitor of neutral endopeptidase. By elevating the levels of atrial natriuretic peptides, Candoxatrilat exerts its diuretic and natriuretic effects. Candoxatrilat is utilized in the research of heart failure .

HY-110186

PQ-69	Adenosine Receptor	Metabolic Disease
PQ-69 is a potent and selective adenosine A1 receptor antagonist with inverse agonist activity. PQ-69 binds to hA1 receptor with a K_i value of 0.96 nM, is 217-fold more selective compared with hA2A receptors (K_i=208 nM) and >1,000-fold selectivity over hA3 receptor (K_i >100 μM). PQ-69 can be used for the research of renal dysfunction .

HY-15195R

Avosentan (Standard) Ro 67-0565 (Standard); SPP-301 (Standard)	Reference Standards Endothelin Receptor	Cardiovascular Disease Endocrinology
Avosentan (Standard) is the analytical standard of Avosentan (HY-15195). This product is intended for research and analytical applications. Avosentan is an orally active endothelin (ETA) receptor antagonist. Avosentan can block the ETA receptor, thereby reducing vascular contraction, and exerting a renal protective effect. Avosentan inhibits vascular contraction caused by ET-1 and alleviates the reduction in retinal and optic nerve head blood flow induced by it, lowering intraocular pressure in the glaucoma monkey model. Avosentan non-specifically blocks ETB receptors at high doses, inhibiting ETB-mediated diuresis and natriuresis, and may cause fluid retention. Avosentan can be used to reduce proteinuria with diabetic nephropathy, but induces significant fluid overload and congestive heart failure.

HY-N18741

Alisma plantago extract	Others	Cardiovascular Disease Inflammation/Immunology
Alisma Plantago Extract is a natural compound aiding in studying multifarious afflictions such as hypertension research, diuresis promotion and inflammation.

HY-181237

CAI-IN-6	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
CAI-IN-6 (Compound 3F) is a carbonic anhydrase (CAI) inhibitor with a K_i of 902.1 nM against hCA I and a K_i of 86.1 nM against hCA II. CAI-IN-6 can be used for the research of diuresis, glaucoma, epilepsy, tumors, and other conditions .

HY-165456

AGN-190851	Adrenergic Receptor Vasopressin Receptor	Endocrinology
AGN-190851 is a potent and selective agonist of α₂-adrenergic receptor (α₂ adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α₂-adrenergic receptor subtypes, and parturition .

HY-124470

Amisometradine	Others	Cardiovascular Disease
Amisometradine is an orally active aminouracil diuretic with a diuretic potency approximately 40% that of Mersalyl (HY-108868) (when administered intramuscularly). Amisometradine exerts its effects by promoting the excretion of sodium, chloride and a small amount of potassium, exhibits significant therapeutic effects in heart failure models, and has good tolerance with long-term administration. Compared with drugs of the same class, Amisometradine causes fewer gastrointestinal reactions; its minor side effects mainly include nausea, vomiting, diarrhea, tinnitus and deafness, and are usually not accompanied by proteinuria or abnormalities in blood and urine indicators. Amisometradine is an important tool for the study of heart failure and related diuretic mechanisms .

Cat. No.	Product Name	Target	Research Area