Aminohippurate sodium
Based on 4 publication(s) in Google Scholar
Aminohippurate sodium (Sodium p-aminohippurate) is a renal tubular transport inhibitor and a substrate for organic anion transporters. Aminohippurate sodium inhibits renal tubular reabsorption of phosphate and promotes increased urinary phosphate excretion. Aminohippurate sodium inhibits renal tubular reabsorption of vitamin C as well as the transport of glucose.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 94-16-6
- Formula: C9H9N2NaO3
- Molecular Weight:216.17
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Aminohippurate sodium
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Biological Activity
Aminohippurate (2 h) acts as a specific transport substrate for organic anion transporters in primary chicken renal tubular epithelial cells, enabling detection of significant decreases in net transport induced by diclofenac with a p-value of 0.021[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 94-16-6
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Appearance Solid
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Molecular Weight 216.17
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Formula C9H9N2NaO3
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Color White to light yellow
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SMILES
O=C(O[Na])CNC(C1=CC=C(N)C=C1)=O
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Synonyms
Sodium p-aminohippurate; p-Aminohippuric acid sodium salt
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Acta Pharmacol Sin
Species differences in the hepatobiliary disposition of morphine-6-glucuronide mediated by hepatic transporters in rats and humans. [Abstract]2025 Sep 15. PMID: 40954191 -
Acta Pharmacol Sin
Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified. [Abstract]2021 Feb;42(2):311-322. PMID: 32860005 -
ACS Omega
Identification of New Modulators and Inhibitors of Palmitoyl-Protein Thioesterase 1 for CLN1 Batten Disease and Cancer. [Abstract]2024 Feb 28;9(10):11870-11882. PMID: 38496939 -
Environ Sci Pollut Res Int
2018 Feb;25(4):3765-3774. PMID: 29168138
Solvent & Solubility
H2O : 100 mg/mL (462.60 mM; Need ultrasonic)
DMSO : 44.44 mg/mL (205.58 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.56 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (462.60 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.6260 mL | 23.1299 mL | 46.2599 mL | 115.6497 mL |
| 5 mM | 0.9252 mL | 4.6260 mL | 9.2520 mL | 23.1299 mL | |
| 10 mM | 0.4626 mL | 2.3130 mL | 4.6260 mL | 11.5650 mL | |
| 15 mM | 0.3084 mL | 1.5420 mL | 3.0840 mL | 7.7100 mL | |
| 20 mM | 0.2313 mL | 1.1565 mL | 2.3130 mL | 5.7825 mL | |
| 25 mM | 0.1850 mL | 0.9252 mL | 1.8504 mL | 4.6260 mL | |
| 30 mM | 0.1542 mL | 0.7710 mL | 1.5420 mL | 3.8550 mL | |
| 40 mM | 0.1156 mL | 0.5782 mL | 1.1565 mL | 2.8912 mL | |
| 50 mM | 0.0925 mL | 0.4626 mL | 0.9252 mL | 2.3130 mL | |
| 60 mM | 0.0771 mL | 0.3855 mL | 0.7710 mL | 1.9275 mL | |
| 80 mM | 0.0578 mL | 0.2891 mL | 0.5782 mL | 1.4456 mL | |
| 100 mM | 0.0463 mL | 0.2313 mL | 0.4626 mL | 1.1565 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Aminohippurate sodium Related Classifications
HY-A0080 Related Classifications
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- Aminohippurate
- 94-16-6
- Sodium p-aminohippurate
- p-Aminohippuric acid
- Biochemical Assay Reagents
- organic anion transporter substrate
- tubular glucose transport
- tubular phosphate reabsorption
- urinary phosphate excretion
- renal tubular transport inhibitor
- osmotic diuresis
- human subjects
- tubular ascorbic acid reabsorption
- tubular penicillin excretion
- Inhibitor
- inhibitor
- inhibit