1 Result for "

ERK/HIF-1α/GLUT1 pathway

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "ERK/HIF-1α/GLUT1 pathway" in MCE Product Catalog:

3
Licoflavone A
Licoflavone A
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3 Cited Publications
Cat. No.: HY-N4185
CAS No.: 61153-77-3
Category:  

Flavonoids Neurological Disease Leguminosae Flavones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Phosphatase VEGFR PI3K Akt MEK ERK Apoptosis HIF/HIF Prolyl-Hydroxylase GLUT Lactate Dehydrogenase Pyruvate Kinase Hexokinase c-Myc Bcl-2 Family

Licoflavone A is an orally active PTP1B/VEGFR-2 inhibitor, with an IC50 of 54.5 μM against PTP1B, an IC50 of 14.36 μM and a Kd of 142.38 nM against human VEGFR-2. Licoflavone A blocks the PI3K/AKT and MEK/ERK signaling pathways. Licoflavone A induces G1 phase cell cycle arrest, apoptosis via the intrinsic mitochondrial pathway (apoptosis), and inhibits migration, invasion and epithelial-mesenchymal transition (EMT) of gastric cancer cells. Licoflavone A inhibits the proliferation of gastric cancer cells in vitro and in xenograft models. Licoflavone A reduces the expression levels of HIF-1α, GLUT1, LDHA, PKM2 and HK2 in hypoxic gastric cancer cells, decreases glucose uptake and suppresses glycolysis. Licoflavone A can be used in research related to gastric cancer, type 2 diabetes and obesity .
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