1 Result for "

Folitixorin calcium

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "Folitixorin calcium" in MCE Product Catalog:

Cat. No.: HY-14769A
CAS No.: 133978-75-3
Synonyms: 5,10-Methylenetetrafolate calcium; ANX-510
Target:  

Thymidylate Synthase

Research Areas:  

Cancer

Folitixorin calcium (5,10-Methylenetetrafolate calcium; ANX-510) is a reduced form of Folic acid (HY-16637) and a cofactor of thymidylate synthase . Folitixorin calcium acts as an essential cofactor to promote the formation of a tight ternary complex between thymidylate synthase and FdUMP, thereby enhancing the inhibitory effect of FdUMP on thymidylate synthase. Folitixorin calcium in combination with 5-fluorouracil and αVEGF reduces tumor volume in colorectal tumor models of nude mice. Folitixorin calcium is used in related research on Yoshida sarcoma, P-388 leukemia, and colorectal cancer .
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