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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Gemcitabine triphosphate
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Gemcitabine triphosphate" in MCE Product Catalog:
Cat. No.: HY-17026A
CAS No.: 110988-86-8
Synonyms: dFdCTP
Cat. No.: HY-17026E
Synonyms: dFdCTP trisodium
Cat. No.: HY-W791041
CAS No.: 116371-66-5
Synonyms: dFdCDP
Target:
Research Areas:
Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects .
Cat. No.: HY-185843
CAS No.: 1062136-15-5
Synonyms: dFdUTP
Target:
Research Areas:
2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
