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Cat. No.: HY-W791041

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Gemcitabine 5'-diphosphate

(Synonyms: dFdCDP)

Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects.

For research use only. We do not sell to patients.

CAS No.: 116371-66-5
Formula: C₉H₁₃F₂N₃O₁₀P₂
Molecular Weight:423.16

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Gemcitabine 5'-diphosphate Chemical Structure

CAS No.: 116371-66-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

Description

All DNA/RNA Synthesis Isoforms :

In Vitro

Gemcitabine 5'-diphosphate potently inhibits ribonucleotide reductase, depleting deoxyribonucleotide pools and enhancing gemcitabine phosphorylation via reduced dCTP-mediated feedback inhibition of dCK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 116371-66-5
Molecular Weight 423.16
Formula C₉H₁₃F₂N₃O₁₀P₂
SMILES

NC(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)=NC1=O
Synonyms

dFdCDP
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Mini E, et al. Cellular pharmacology of gemcitabine. Annals of oncology : official journal of the European Society for Medical Oncology. 2006 May;17 Suppl 5:v7-12. [Content Brief]

[2]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
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Gemcitabine 5'-diphosphate

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Gemcitabine 5'-diphosphate Related Classifications

HY-W791041 Related Classifications