116371-66-5
Chemical Structure
Gemcitabine 5'-diphosphate
Synonym(s): dFdCDP
- CAS 番号: 116371-66-5
- Formula:C9H13F2N3O10P2
- Molecular Weight:423.16
InChIKey: FRQISCZGNNXEMD-QPPQHZFASA-N
SMILES: NC(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(O)(O)=O)(O)=O)O2)=NC1=O
Biological Activity: Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects[1][2].
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Gemcitabine 5'-diphosphate | Gemcitabine 5'-diphosphate (dFdCDP) is a core active metabolic intermediate of Gemcitabine (HY-17026) and a potent ribonucleotide reductase (RNR) inhibitor. Gemcitabine 5'-diphosphate depletes deoxyribonucleotide pools, consumes deoxycytidine triphosphate and increases the phosphorylation level of gemcitabine. Gemcitabine 5'-diphosphate prolongs the intracellular retention duration of gemcitabine metabolites, enhances the nucleic acid incorporation of gemcitabine, and exerts anti-tumor/cytotoxic effects. | |||||||||||||||||||||
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- [1]. Mini E, et al. Cellular pharmacology of gemcitabine. Annals of oncology : official journal of the European Society for Medical Oncology. 2006 May;17 Suppl 5:v7-12. [Content Brief]
- [2]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]
Keywords
