2',2'‐Difluorodeoxyuridine 5'‐triphosphate
2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) is the intracellular phosphorylated metabolite of dFdU (HY-138253), which in turn is the deaminated metabolite of Gemcitabine (HY-17026). 2',2'-Difluorodeoxyuridine 5'-triphosphate incorporates into DNA and RNA, contributing to Gemcitabine-associated cytotoxicity and hepatotoxicity. 2',2'-Difluorodeoxyuridine 5'-triphosphate accumulates in the liver and kidneys of mice, and is detectable in mouse plasma and urine. 2',2'-Difluorodeoxyuridine 5'-triphosphate can be used in the research of breast cancer and non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 1062136-15-5
- Formula: C9H13F2N2O14P3
- Molecular Weight:504.12
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) integrates into DNA and RNA after gemcitabine (HY-17026)-sensitive tumor cell lines are incubated with 0.5 μM gemcitabine or dFdU (HY-138253) for 24 h, and this integration directly correlates with the cytotoxicity of dFdU[1].
2',2'-Difluorodeoxyuridine 5'-triphosphate (dFdUTP) exhibits intrinsic toxicity comparable to that of dFdCTP in human hepatocellular carcinoma HepG2 cells, which is evidenced by comparable levels of DNA incorporation at equitoxic precursor concentrations[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1062136-15-5
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Molecular Weight 504.12
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Formula C9H13F2N2O14P3
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SMILES
O=C(C=CN1[C@H]2C(F)(F)[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)NC1=O
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Synonyms
dFdUTP
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Derissen EJB, et al. Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides. British journal of clinical pharmacology. 2018 Jun;84(6):1279-1289. [Content Brief]
[2]. Benyumov A, et al. Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU. ChemMedChem. 2011 Mar 07;6(3):457-64. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
2',2'‐Difluorodeoxyuridine 5'‐triphosphate Related Classifications
HY-185843 Related Classifications
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