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6 Results for "
HIV-1 RT RNase H
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "HIV-1 RT RNase H" in MCE Product Catalog:
Cat. No.: HY-W028350
CAS No.: 40106-12-5
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NSC727447 is a vinyl urea-based allosteric inhibitor of HIV reverse transcriptase-associated RNase H with IC50 values of 2.0 μM and 2.5 μM against HIV-1 and HIV-2 RNase H, respectively, and IC50 values of 100 μM and 10.6 μM against Escherichia coli and human RNase H, respectively. NSC727447 exerts allosteric inhibitory effects mainly by interacting with the region adjacent to α-helix I in the thumb subdomain of the p51 subunit of HIV-1 reverse transcriptase. Cys280, Lys281 and the RNase H primer grip region are involved in its action, and it may inhibit the catalytic activity of RNase H by altering the positioning of nucleic acid substrates or the geometry of the RNase H active site. NSC727447 can be used in studies related to HIV infection, the function of HIV reverse transcriptase RNase H, and allosteric inhibition mechanisms .
Cat. No.: HY-W103287
CAS No.: 6890-08-0
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Hydroxyisoquinoline-1,3(2H,4H)-dione (compound 6a) is a HIV-1 integrase (IN) and HIV-1 reverse transcriptase (RT) ribonuclease H (RNase H) inhibitor with an IC50 value of 6.32, 5.9 µM, respectively .
Cat. No.: HY-185449
CAS No.: 1909302-89-1
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HIV RT-IN-2 is a HIV reverse transcriptase inhibitor with an IC50 value of 1.2 μM for HIV-1 RT RNA-dependent DNA polymerase. HIV RT-IN-2 potently inhibits all three modes of HIV-1 RT-associated RNase H activity (internal, 3'-DNA directed, 5'-RNA directed cleavage) and inhibits HIV-1 replication. HIV RT-IN-2 can be used for the research of HIV-1 infection .
Cat. No.: HY-182552
CAS No.: 65025-62-9
Cat. No.: HY-184700
CAS No.: 3124729-94-5
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HIV-1-IN-94 is a dual inhibitor of HIV-1 integrase (INST) and reverse transcriptase RNase H, with IC50 values of 12 μM and 0.11 μM, respectively. HIV-1-IN-94 inhibits HIV-1 replication with low cytotoxicity. HIV-1-IN-94 can be used in studies related to HIV-1 infection .
Cat. No.: HY-183157
CAS No.: 2366269-07-8
HIV-1-IN-93 is a HIV-1 RNase H inhibitor with an IC50 of 6.09 μM. HIV-1-IN-93 shows low cytotoxicity and can be used in studies related to HIV-1 infection .
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Protocols
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