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Cat. No.: HY-184700

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HIV-1-IN-94

HIV-1-IN-94 is a dual inhibitor of HIV-1 integrase (INST) and reverse transcriptase RNase H, with IC₅₀ values of 12 μM and 0.11 μM, respectively. HIV-1-IN-94 inhibits HIV-1 replication with low cytotoxicity. HIV-1-IN-94 can be used in studies related to HIV-1 infection.

For research use only. We do not sell to patients.

CAS No.: 3124729-94-5
Formula: C₂₁H₁₆N₂O₃
Molecular Weight:344.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HIV-1-IN-94 Chemical Structure

CAS No.: 3124729-94-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1

All HIV Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

HIV-1-IN-94 (Compound 8a-13) (24-72 h) inhibits HIV-1 replication in TZM-GFP cells, with an EC₅₀ of 0.48 μM, a CC₅₀ of 52 μM, and a selectivity index of 110^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3124729-94-5
Molecular Weight 344.36
Formula C₂₁H₁₆N₂O₃
SMILES

CC(C=C1)=CC=C1C2=CN=C(N(O)C(C(C3=CC=CC=C3)=C4O)=O)C4=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shahari MSB, et al. 1,4-Dihydroxy-1,8-napthyridinone (DHN) analogs as HIV-1 reverse transcriptase-associated RNase H inhibitors. Bioorganic chemistry. 2026 Jun 17;180:110119. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HIV-1-IN-94

All HIV Isoforms

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HIV-1-IN-94 Related Classifications

HY-184700 Related Classifications