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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
HK-2-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "HK-2-IN-2" in MCE Product Catalog:
Cat. No.: HY-168717
CAS No.: 3056278-80-6
Research Areas:
HK2-IN-2 (Compound 26) is a Hexokinase 2 inhibitor that demonstrates significant anti-tumor activity by targeting microtubules and Hexokinase 2, with an IC50 value of 0.764 μM against MD-MBA-231 cells. HK2-IN-2 effectively inhibits the activity of Hexokinase 2, leading to the accumulation of Reactive Oxygen Species and dysfunction of the mitochondrial membrane potential (MMP), thereby promoting apoptosis and blocking the cell cycle .
Cat. No.: HY-189292
Research Areas:
HK2-IN-5 is a selective hexokinase 2 (HK2) inhibitor with an IC50 of 1.17 μM against HK2 enzymatic activity. HK2-IN-5 shows weak inhibition against HK3 and GCK (HK4). By inhibiting HK2, HK2-IN-5 induces a decrease in mitochondrial membrane potential (ΔΨm) and accumulation of reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative stress, and its antiproliferative effect is mainly dependent on HK2. HK2-IN-5 can be used in research related to triple-negative breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
