211 Results for "

Heterocyclic

" in MedChemExpress (MCE) Product Catalog:
Products (211)

211 Results for "Heterocyclic" in MCE Product Catalog:

8
8 Publications Verification
Cat. No.: HY-135797A
CAS No.: 2369663-93-2
Purity:  ≥98.0%
Target:  

Apoptosis

Research Areas:  

Cancer

DB1976 dihydrochloride is a selenophene analog of DB270 and a potent and cell-permeable fully efficacious transcription factor PU.1 inhibitor. DB1976 dihydrochloride potently inhibits PU.1 binding (IC50 of 10 nM) and strongly inhibits the PU.1/DNA complex (with high DB1976-λB affinity, KD of 12 nM) in vitro. DB1976 dihydrochloride has apoptosis-inducing effect .
loading...
    loading...
8
8 Publications Verification
Cat. No.: HY-N6693
CAS No.: 2001-95-8
Synonyms: NSC 122023
Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
loading...
    loading...
6
6 Cited Publications
Cat. No.: HY-W007355
CAS No.: 83-34-1
Synonyms: 3-Methylindole; 3-Methyl-1H-indole
Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors (AhR) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-Y0061
CAS No.: 59-48-3
Synonyms: 2-Indolinone
Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-W001132
CAS No.: 120-72-9
Indole is an aromatic, heterocyclic, organic compound which widely distributed in the natural environment and can be produced by a variety of bacteria. Indole regulates various aspects of bacterial physiology, including spore formation, plasmid stability, resistance to drugs, biofilm formation, and virulence as an intercellular signal molecule .
loading...
    loading...
3
3 Cited Publications
Cat. No.: HY-D0837
CAS No.: 288-32-4
Synonyms: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene
Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-B1223
CAS No.: 532-11-6
Anethole trithione, a sulfur heterocyclic choleretic, is a bile secretion-stimulating agent. Anethole trithione enhances salivary secretion and increases mAChRs, and can be used for dry mouth research .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-12396
CAS No.: 96-50-4
Purity:  99.98%
Synonyms: 2-Aminothiazole; 2-Thiazolylamine
Research Areas:  

Infection

Aminothiazole (2-Aminothiazole), a typical heterocyclic amine, is a precursor for the synthesis of biologically active molecules including sulfur agents, biocides, fungicides, antibiotics, dyes and chemical reaction accelerators .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W018800
CAS No.: 491-36-1
4(3H) -quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-124855
CAS No.: 893075-58-6
Purity:  99.78%
Target:  

Deubiquitinase

Research Areas:  

Cancer

STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-W007712
CAS No.: 3430-17-9
Synonyms: 2-Bromo-3-picoline
2-Bromo-3-methylpyridine (2-Bromo-3-picoline) is a heterocyclic intermediate of the halomethylpyridine family. 2-Bromo-3-methylpyridine can be used in the synthesis of platinum(IV) diazide complexes .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-118716
CAS No.: 105650-23-5
Purity:  99.93%
Synonyms: 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat . DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-P1206
CAS No.: 174688-78-9
Target:  

Somatostatin Receptor

Research Areas:  

Neurological Disease

CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
loading...
    loading...
1
1 Cited Publications
Cat. No.: HY-Y0032
CAS No.: 79-19-6
Target:  

Orthopoxvirus

Research Areas:  

Infection Others Cancer

Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals .
loading...
    loading...
Cat. No.: HY-W012634
CAS No.: 95-16-9
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent [1][2][3][4].
loading...
    loading...
Cat. No.: HY-P10033
CAS No.: 245080-24-4
Target:  

Ser/Thr Protease

Research Areas:  

Others

SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .
loading...
    loading...
Cat. No.: HY-Y1078
CAS No.: 4637-24-5
Synonyms: N-Dimethoxymethyl-N,N-dimethylamine
Research Areas:  

Others

DMF-DMA (N-Dimethoxymethyl-N,N-dimethylamine) is a reagent with both condensation and alkylation functions. DMF-DMA can undergo condensation reactions with active methylene groups or amino groups to generate enamine and imino derivatives, and can also act as an alkylating agent to methylate nitrogen and oxygen atoms in heterocyclic structures. DMF-DMA is widely used in the synthesis of enaminones and dimethylamino imine intermediates, as well as in the construction of heterocyclic backbones such as pyridine, pyrimidine and pyrazole. DMF-DMA can also serve as a polar aprotic co-solvent; although DMF-DMA cannot dissolve cellulose alone, it can form an efficient cellulose dissolution system with diallylimidazolium methoxyacetate .
loading...
    loading...
Cat. No.: HY-21179
CAS No.: 27607-77-8
Research Areas:  

Others

Trimethylsilyl trifluoromethylsulfonate is a metal-free catalyst. Trimethylsilyl trifluoromethylsulfonate can be used for the synthesis of biologically active fluorinated heterocyclic compounds .
loading...
    loading...
Cat. No.: HY-103656
CAS No.: 917-23-7
Purity:  99.43%
Synonyms: TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin
Target:  

MOFs

Research Areas:  

Cancer

Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .
loading...
    loading...
Cat. No.: HY-W016349
CAS No.: 138-60-3
Research Areas:  

Others

Chelidamic acid is a heterocyclic organic acid with a pyran skeleton. Chelidamic acid has good coordination ability with noble metal ions. Chelidamic acid is also one of the most potent inhibitors of glutamate decarboxylase, with a Ki of 33 μM.
loading...
    loading...