105650-23-5
105650-23-5
Chemical Structure
PhIP
Synonym(s): 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
- CAS No.: 105650-23-5
- Formula:C13H12N4
- Molecular Weight:224.26
IUPAC Name: 1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine
InChIKey: UQVKZNNCIHJZLS-UHFFFAOYSA-N
SMILES: NC1=NC2=NC=C(C=C2N1C)C3=CC=CC=C3
Biological Activity: PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat[1][2]. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PhIP | 99.93% | PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity. | ||||||||||||||||||||
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PhIP (Standard) | ≥98% | PhIP (Standard) is the analytical standard of PhIP. This product is intended for research and analytical applications. PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity. | ||||||||||||||||||||
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PhIP-d3 | PhIP-d3 (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-d3) is the deuterium labeled PhIP (HY-118716). PhIP (2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) is the most abundant of generation of heterocyclic amines (HCA), resulted in the cooking of meat. DNA damaging and mutagenic activities. PhIP also has oestrogenic activity that could contribute to its tissue specific carcinogenicity. | |||||||||||||||||||||
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Structural Analogs
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HY-138806PAQ -
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HY-W703355Mebendazole impurity 2 -
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HY-101957AG 1295 -
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![2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine-<sup>13</sup>C Chemical Structure](//file.medchemexpress.com/product_pic/hy-w281364s.gif)
HY-W281364S2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine-13C -
Similarity Score 0.59
HY-W355129MeIQx -
Similarity Score 0.59
HY-W779191MeIQx-13C -
Similarity Score 0.59
HY-111662Fc 11a-2 -
Similarity Score 0.58
HY-1138762-Methyl-3-phenylquinoxaline -
Similarity Score 0.58
HY-13894RTyrphostin AG1296 (Standard) -
Explore the MedChemAI to find more analogs
![2-Ammo-3-memyl-imidazo-[4,5-f]-quinoIine-<sup>13</sup>C Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w281364s.gif)
References
- [1]. Bellamri M, et al. Metabolic Activation of the Cooked Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine in Human Prostate. Toxicol Sci. 2018 Jun 1;163(2):543-556. [Content Brief]
- [2]. Papaioannou MD, et ak. The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells. Toxicol Lett. 2014 Aug 17;229(1):9-16. [Content Brief]
