Search Result

Isoforms Recommended:	IL-10

Results for "

IL-10

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (105) IRAK (7) Adenosine Deaminase (1) Adenosine Receptor (8) Akt (5) AMPK (4) Antibiotic (1) AP-1 (2) Apoptosis (26) Arrestin (1) Autophagy (4) Bacterial (4) Bcl-2 Family (1) Biochemical Assay Reagents (2) Calcium Channel (2) Cannabinoid Receptor (3) Caspase (4) CCR (1) CD28 (1) CD3 (1) CDK (5) COX (5) CXCR (1) Drug Derivative (2) Endogenous Metabolite (12) Environmental Pollutants (3) ERK (2) Ferroptosis (2) FLT3 (6) Formyl Peptide Receptor (FPR) (2) FOXO (1) Fungal (2) Glucocorticoid Receptor (3) GSK-3 (4) HDAC (8) Heme Oxygenase (HO) (2) HIF/HIF Prolyl-Hydroxylase (2) HSV (1) IFNAR (10) Influenza Virus (2) Insecticide (1) Integrin (2) Isotope-Labeled Compounds (6) JAK (2) JNK (1) Keap1-Nrf2 (6) Lactate Dehydrogenase (1) Leukotriene Receptor (3) Lipoxygenase (2) MALT1 (3) MHC (1) Mitophagy (1) MMP (1) mRNA (10) mTOR (2) MyD88 (7) nAChR (2) Neurokinin Receptor (2) NF-κB (18) NO Synthase (5) NOD-like Receptor (NLR) (6) Opioid Receptor (1) Orphan Nuclear Receptor (2) p38 MAPK (6) PACAP Receptor (1) Parasite (4) PARP (1) PGE synthase (1) Phosphodiesterase (PDE) (10) PI3K (5) PKA (2) Platelet-activating Factor Receptor (PAFR) (1) Polo-like Kinase (PLK) (1) Prostaglandin Receptor (1) PROTACs (3) PTEN (1) Reactive Oxygen Species (ROS) (8) Reference Standards (10) Salt-inducible Kinase (SIK) (4) SARS-CoV (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (7) SOD (1) STAT (2) STING (1) Syk (1) Tau Protein (2) TGF-β Receptor (4) TNF Receptor (43) Toll-like Receptor (TLR) (13) TRP Channel (1) UGT (1) VSV (1) Wnt (1)
By Research Areas:	Cancer (49) Cardiovascular Disease (9) Endocrinology (3) Infection (19) Inflammation/Immunology (136) Metabolic Disease (12) Neurological Disease (23)
Oligonucleotides:	Interferon & Receptors (4) Thickeners (1) CpG ODNs (1) Rat Pre-designed siRNA Sets (2) Emulsifiers (1) mRNA (11) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) Antisense Oligonucleotides (2) Interleukin & Receptors (6) siRNAs (7)

173

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Interleukin Related IRAK Itk

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1829A

Dexamethasone phosphate disodium 10+ Cited Publications Dexamethasone 21-phosphate disodium	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) disodium is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate disodium is produced by introducing a phosphate ester group at the 21-position of the Dexamethasone molecule, forming a salt with sodium ions, thereby significantly improving water solubility. Dexamethasone phosphate disodium inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate disodium inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and IL-10, and blocks microglial migration. Dexamethasone phosphate disodium is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate disodium can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-N0405

Orientin 5+ Cited Publications	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases *IL-10* level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-A0103

Xanthan gum	Environmental Pollutants Biochemical Assay Reagents	Inflammation/Immunology
Xanthan gum interacts with gelatin (HY-Y1365) via hydrogen bonds, thereby increasing the viscosity and stability of the hydrogel while promoting cell growth and creating a microenvironment conducive to cell differentiation ^[1][2]. Xanthan gum induces pro-inflammatory responses by increasing the levels of TNF-α, IL-6, and *IL-10*. Xanthan gum can be used for inflammation and immunology research .

HY-110133

JTE-607 5 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and *IL-10, from LPS-stimulated human PBMCs, with IC₅₀*s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-159657

PF-07899895	Salt-inducible Kinase (SIK) Interleukin Related	Inflammation/Immunology
PF-07899895 (Compound 34) is a SIK inhibitor, with IC₅₀ values of 1.2 nM, 0.9 nM, and 1.8 nM against SIK1, SIK2, and SIK3, respectively. PF-07899895 modulates the anti-inflammatory cytokine *IL-10* in immune cells. PF-07899895 is applicable to research related to inflammatory diseases .

HY-113494

Sitostanol 1 Publications Verification Stigmastanol; 24α-Ethyl cholestanol	Interleukin Related	Others Metabolic Disease Inflammation/Immunology Cancer
Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and *IL-10*. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma .

HY-130321

Lauroyl-L-carnitine chloride 1 Publications Verification	Endogenous Metabolite Interleukin Related	Inflammation/Immunology
Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene *IL-10*. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-101019

Ossirene 2 Publications Verification AS101	Interleukin Related Caspase	Inflammation/Immunology Cancer
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting *IL-10. Ossirene potently inhibits Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .

HY-N6607

Tryptanthrin 5+ Cited Publications	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-122586

BRD6989 2 Publications Verification	CDK Interleukin Related	Inflammation/Immunology
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates *IL-10. BRD6989 selectively binds a complex of CDK8 with an IC₅₀* of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes .

HY-B1051

Flumethasone 1 Publications Verification Flumetasone	Glucocorticoid Receptor TNF Receptor Interleukin Related Keap1-Nrf2	Inflammation/Immunology Endocrinology Cancer
Flumethasone (Flumetasone) is an orally active, high selective and potent glucocorticoid receptor (GR) agonist. Flumethasone activates GR to inhibit nuclear factor kappa B (NF-κB)-mediated pro-inflammatory cytokine production (TNF-α, IL-1β) and promotes anti-inflammatory gene expression (IL-10), while also regulating metabolic enzyme activity (tyrosine aminotransferase induction). Flumethasone is promising for research of inflammatory diseases, cancer, and endocrine regulation .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Environmental Pollutants Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-P990228

*Anti-Mouse IL-10R/CD210 Antibody (1B1.3A)*	Interleukin Related Parasite Fungal	Infection Metabolic Disease
Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse *IL-10R/CD210. Anti-Mouse IL-10R/CD210* Antibody (1B1.3A) blocks IL-10R signaling. Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) can be used for the researches of cancer, infection and metabolic disease, such as diabetes and malaria .

HY-14837

Amizon Enisamium iodide	Influenza Virus SARS-CoV	Infection
Amizon is an orally effective antiviral and anti-inflammatory agent. Amizon inhibits influenza virus replication and restricts viral RNA synthesis. Amizon reduces the mRNA expression of COX-1, COX-2, NF-κB, TGF1β, IL-1 and IL-6, and stimulates the secretion and mRNA expression of IL-10. Amizon inhibits the oxidative activity of macrophages and possesses antioxidant and free radical-scavenging activities. Amizon is applicable to research related to influenza and acute respiratory viral infections .

HY-P990001

*Anti-Mouse IL-10* Antibody (JES5-2A5)** 1 Publications Verification	Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse *IL-10* IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM) .

HY-135317

Emavusertib 5+ Cited Publications CA-4948	IRAK Apoptosis FLT3 NF-κB MyD88	Inflammation/Immunology Cancer
Emavusertib is an orally active inhibitor for IRAK4 (IC₅₀=57 nM) and FLT3. Emavusertib inhibits NF-κB and MyD88 signaling pathways, reduces the generation of pro-inflammatory cytokines like IL-6 and IL-10, thereby exhibiting anti-inflammatory and anti-proliferative activities against cancer cells, leading to cell apoptosis. Emavusertib exhibits antitumor activity in mouse model

HY-107390A

AX-024 hydrochloride 3 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-107390

AX-024 3 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-110353

CU-T12-9 10+ Cited Publications	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .

HY-124344

Avenanthramide C	Interleukin Related	Neurological Disease
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-147506

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

HY-175479

GLPG4970	Salt-inducible Kinase (SIK) TNF Receptor Interleukin Related	Inflammation/Immunology
GLPG4970 is a potent, selective and orally active salt-inducible kinase 2/3 (SIK2/SIK3) dual inhibitor with IC₅₀ values of 0.3 nM and 0.7 nM. GLPG4970 has weak inhibition of hERG channel with an IC₅₀ of 29 μM. GLPG4970 can decrease TNFα release and increase IL-10 release GLPG4970 can be used for the researches of inflammation and immunology, such as colitis .

HY-173679

RBN012811	PROTACs PARP Interleukin Related STAT Integrin HSV VSV	Infection Cancer
RBN012811 is a highly selective PROTAC-based PARP14 degrader. RBN012811 forms a ternary complex with cereblon by binding to the NAD ⁺site of PARP14, and mediates the specific degradation of PARP14 via the ubiquitin-proteasome pathway (IC₅₀=10 nM). RBN012811 effectively depletes endogenous PARP14 in various cell lines and primary human macrophages, thereby downregulating *IL-10* production and IFN-β mRNA levels, increasing phosphorylated STAT1 levels to enhance inflammatory signaling, and inhibiting interferon-induced ADPr condensate formation. RBN012811 also modulates viral replication, exhibiting increased HSV1 replication while reducing VSV replication. RBN012811 has important application value in research related to cancer and viral infections .

HY-174646

*Human IL10* mRNA**	mRNA	Inflammation/Immunology
Human IL10 mRNA is the messenger ribonucleic acid that encodes human IL-10. The expression of IL-10 mRNA is highly inducible and cell type-specific.

HY-N14039

Pinus pinaster bark extract	Toll-like Receptor (TLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of *IL-10* .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-N8249

Cynandione A	nAChR Interleukin Related	Inflammation/Immunology
Cynandione A is an acetophenone that can be isolated from Cynanchum Wilfordii Radix. Cynandione A protects hepatocytes and cortical neurons from toxicity and improves neurological deficits in a rat model of cerebral ischemia. On the other hand, cynandione A has significant anti-inflammatory effects and inhibits inflammation by activating macrophage α7 nAChR and IL-10 expression .

HY-109540

Perfluorohexane AF-0150	Heme Oxygenase (HO) Interleukin Related	Inflammation/Immunology
Perfluorohexane (AF-0150) is a perfluorocarbon. Perfluorohexane is also an enhancer of high-intensity focused ultrasound (HIFU) therapy. Perfluorohexane increases HO-1 and IL-10. Perfluorohexane exerts an antioxidant effect. Perfluorohexane alleviates lung injury induced by LPS (HY-D1056A1). Perfluorohexane improves the efficiency and precision of HIFU and reduces damage to surrounding normal tissues. Perfluorohexane can be used in the study of acute lung injury .

HY-NP134

Flagellin from S. typhimurium	Toll-like Receptor (TLR) MyD88 NF-κB Interleukin Related IFNAR	Inflammation/Immunology Cancer
Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting *IL-10* production, and increasing the *IFN-γ/IL-10* ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases .

HY-P990561

BT-063	Interleukin Related	Inflammation/Immunology
BT-063 is a humanized antibody expressed in CHO cells, targeting *IL-10*. BT-063 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for BT-063 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-101757

NO-prednisolone NCX-1015	Interleukin Related	Inflammation/Immunology
NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone. NO-prednisolone potently stimulates *IL-10* production in vivo.

HY-130321S

Lauroyl-L-carnitine-d3 chloride	Isotope-Labeled Compounds Interleukin Related Endogenous Metabolite	Inflammation/Immunology
Lauroyl-L-carnitine-d₃ (chloride) is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene *IL-10*. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-B1829

Dexamethasone phosphate 10+ Cited Publications Dexamethasone 21-phosphate	Glucocorticoid Receptor TGF-β Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
Dexamethasone phosphate (Dexamethasone 21-phosphate) is a prodrug form of the glucocorticoid Dexamethasone (HY-14648). Dexamethasone phosphate is prepared by introducing a phosphate ester group to the hydroxyl group at position 21 of the Dexamethasone molecule. Dexamethasone phosphate inhibits LPS (HY-D1056)-induced degradation of IRAK-1 and IRAK-4, and blocks LPS-induced activation of TRAF6, p-TAK1 and p-JNK. Dexamethasone phosphate inhibits the secretion of RANTES, TGF-β1 and NO, promotes the production of MIP-1α and *IL-10*, and blocks microglial migration. Dexamethasone phosphate is almost completely converted to Dexamethasone in rat blood, and supports transdermal delivery via iontophoresis. Dexamethasone phosphate can be used in research related to steroid-dependent ulcerative colitis, chemotherapy-induced vomiting, allergic asthma and acute colitis (inflammatory bowel disease) .

HY-161440

SIK-IN-1	AMPK	Inflammation/Immunology
SIK-IN-1 (Compound 53) is an inhibitor for salt-inducible kinase (SIK), which inhibits SIK1, SIK2 and SIK3 with IC₅₀s of 0.1, 0.4 and 1.5 nM, respectively. SIK-IN-1 inhibits the release of TNFa with IC₅₀ of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC₅₀ of 4 nM in human macrophages .

HY-N6607R

Tryptanthrin (Standard)	Reference Standards Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-110067

VO-OHPic	PTEN Apoptosis Autophagy Ferroptosis Reactive Oxygen Species (ROS) Interleukin Related Akt Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology Cancer
VO-OHPic is a reversible, noncompetitive PTEN inhibitor with an human IC₅₀ value of 46 nM. VO-OHPic inhibits PTEN signaling, activates Akt-GSK3β and Nrf-2/HO-1 pathways, induces apoptosis resistance and elevates *IL-10* levels. VO-OHPic inhibits autophagy, ferroptosis and oxidative stress. VO-OHPic can be used for the research of acute myocardial infarction, intervertebral disc degeneration, cardiomyopathy and cancer .

HY-P3483

Maxadilan	PACAP Receptor Caspase Apoptosis PKA Interleukin Related TNF Receptor	Cardiovascular Disease Neurological Disease
Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases ^{[1] [2] [3] [4] [5]}.

HY-177608

*Rat IL10* mRNA**	Interleukin Related	Inflammation/Immunology
Rat IL-10 mRNA encodes interleukin-10 (IL-10). IL-10 is expressed in tissues/cells such as hepatic stellate cells and is involved in physiological processes including liver fibrosis.

HY-147527

CDK8-IN-5	CDK	Inflammation/Immunology
CDK8-IN-5 is a potent CDK8 inhibitor with an IC₅₀ of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease .

HY-N7697C

Chitohexaose hexahydrochloride	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates *IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β* and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-130321S1

Lauroyl-L-carnitine-d9 chloride	Isotope-Labeled Compounds Endogenous Metabolite Interleukin Related	Inflammation/Immunology
Lauroyl-L-carnitine-d₉ chloride is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene *IL-10*. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-107909

Theophylline sodium glycinate 1,3-Dimethylxanthine sodium glycinate; Theo-24 sodium glycinate	Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-RS06671

Il10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Mouse Pre-designed siRNA Set A Il10 Mouse Pre-designed siRNA Set A

HY-RS06670

IL10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
IL10 Human Pre-designed siRNA Set A contains three designed siRNAs for IL10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10 Human Pre-designed siRNA Set A IL10 Human Pre-designed siRNA Set A

HY-P991659

SCH708980	Interleukin Related	Infection Inflammation/Immunology
SCH708980 is a humanized monoclonal antibody inhibitor targeting *IL-10*. SCH708980 has anti-immunosuppressive activity. SCH708980 can be used for visceral leishmaniasis, sepsis-associated kidney injury (SAKI) and osteoporosis research .

HY-RS06672

Il10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Interleukin Related	Others
Il10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Rat Pre-designed siRNA Set A Il10 Rat Pre-designed siRNA Set A

HY-178240

rel-(1S,2R)-Dihydro bupropion	Interleukin Related Endogenous Metabolite TNF Receptor	Inflammation/Immunology
rel-(1S,2R)-Dihydro bupropion is a metabolite of bupropion. rel-(1S,2R)-Dihydro bupropion can promote endogenous *IL-10* production and inhibit Th1 cytokines (IL-12 and TNF-α). rel-(1S,2R)-Dihydro bupropion can induce immune response transition from Th1 to Th2. rel-(1S,2R)-Dihydro bupropion can be used for research on inflammatory conditions .

Cat. No.	Product Name	Type

HY-A0103

Xanthan gum

Biochemical Assay Reagents

Xanthan gum interacts with gelatin (HY-Y1365) via hydrogen bonds, thereby increasing the viscosity and stability of the hydrogel while promoting cell growth and creating a microenvironment conducive to cell differentiation ^[1][2]. Xanthan gum induces pro-inflammatory responses by increasing the levels of TNF-α, IL-6, and IL-10. Xanthan gum can be used for inflammation and immunology research .

HY-NP134

Flagellin from S. typhimurium

Biochemical Assay Reagents

Flagellin from S. typhimurium is a potent TLR5 agonist. Flagellin from S. typhimurium activates immune cells and inhibits the activity of melanoma cells. Flagellin from S. typhimurium activates the NF-κB pathway dependent on the TLR5/MyD88/TRAF6 signaling axis in cells. Flagellin from S. typhimurium induces a proinflammatory response in the primary chicken hepatocyte-nonparenchymal cell co-culture system by promoting IL-8 production, inhibiting IL-10 production, and increasing the IFN-γ/IL-10 ratio. Flagellin from S. typhimurium can be used for research on melanoma and inflammatory diseases .

HY-D1056C1

Lipopolysaccharides, from S. enterica serotype enteritidis

LPS, from Salmonella enterica (Serotype enteritidis)

Biochemical Assay Reagents

Lipopolysaccharides, from S. enterica (Salmonella enterica) serotype enteritidis are lipopolysaccharide endotoxins and TLR-4 activators derived from the enteritidis serotype of S. enterica, classified as S-type LPS, which can activate pathogen-associated molecular patterns (PAMP) of the immune system and induce cellular secretion of migrasomes. Lipopolysaccharides, from S. enterica serotype enteritidis exhibit a typical three-part structure: O-antigen, core oligosaccharide, and lipid A. Lipopolysaccharides, from S. enterica serotype enteritidis can induce systemic inflammatory responses, increasing levels of TNF-α, IFN-γ, IL-6, IL-10, and nitrate in plasma .
It is recommended to prepare a solution with concentration ≥2 mg/mL. Vortex thoroughly for more than 10 minutes. Due to the adsorption characteristics of LPS, silanized container or low adsorption centrifuge tubes should be used for aliquoting and storage, and mix thoroughly before use.

HY-W145695

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis .

Cat. No.	Product Name	Target	Research Area

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2114

IT9302	Peptides	Cancer
IT9302 is a synthetic IL-10 agonist with the activity of inducing tolerogenic dendritic cells. IT9302 is able to mimic multiple effects of IL-10, including downregulating the antigen presentation machinery and increasing the sensitivity of tumor cells to natural killer cell-mediated lysis. IT9302 can also hinder the response of human monocytes to differentiation factors and reduce the antigen presentation and co-stimulatory capacity of dendritic cells. Dendritic cells treated with IT9302 showed a weakened ability to stimulate T cell proliferation and interferon-γ production. IT9302 exerts its effects through mechanisms that are partially different from IL-10, involving STAT3 inactivation and regulation of the NF-κB intracellular pathway. IT9302-treated dendritic cells showed enhanced expression of membrane-bound TGF-β, associated with the effective induction of foxp3+ regulatory T cells .

HY-P3483

Maxadilan	PACAP Receptor Caspase Apoptosis PKA Interleukin Related TNF Receptor	Cardiovascular Disease Neurological Disease
Maxadilan is a specific irreversible PAC1 receptor agonist and a potent vasodilator peptide present in the salivary glands of sand flies. Maxadilan exhibits anti-apoptotic activity in hADSCs. Maxadilan inhibits pro-inflammatory cytokines (TNF-α) and enhances anti-inflammatory mediators (IL-10). Maxadilan can activate leukocytes and inhibit vascular permeability through PAC1 receptors. Maxadilan promotes neural differentiation of human adipose-derived stem cells. Maxadilan can be used to study endotoxin shock, atherosclerosis, and neurodegenerative diseases ^{[1] [2] [3] [4] [5]}.

HY-P11004

A3-APO	Bacterial Antibiotic	Infection
A3-APO is an antimicrobial peptide. A3-APO has a significant antimicrobial activity by a dual mode of action with both membrane disintegration and intracellular target inhibition. A3-APO can deactivate bacterial toxins and increase the expression of anti-inflammatory cytokines (such as IL-4 and IL-10), without antimicrobial resistance. A3-APO accelerates burn wounds healing in mice infection model of Acinetobacter baumannii and Staphylococcus aureus .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2320

IDR-1	Bacterial	Infection Inflammation/Immunology
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-167153

PNA5	Interleukin Related Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
PNA5 is a novel, blood-brain barrier permeable glycosylated angiotensin-(1-7) peptide and MasR agonist. PNA5 inhibits IL-7, increases *IL-10. PNA5 inhibits ROS* generation, decreases Iba-1 expression. PNA5 exhibits sustained cognitive protective effects. PNA5 rescues blunted cerebral functional hyperemia. PNA5 can be used in the research of inflammation-related brain diseases .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990228

*Anti-Mouse IL-10R/CD210 Antibody (1B1.3A)*	Interleukin Related Parasite Fungal	Infection Metabolic Disease
Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) is a rat-derived IgG1 κ type antibody inhibitor, targeting to mouse *IL-10R/CD210. Anti-Mouse IL-10R/CD210* Antibody (1B1.3A) blocks IL-10R signaling. Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) can be used for the researches of cancer, infection and metabolic disease, such as diabetes and malaria .

HY-P990001

*Anti-Mouse IL-10* Antibody (JES5-2A5)** 1 Publications Verification	Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse *IL-10* IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for researches on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM) .

HY-P991400

GSK1995057	TNF Receptor Apoptosis Interleukin Related NF-κB JNK p38 MAPK	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 selectively binds to TNFR1, blocks the binding of TNF-α and LT-α, and does not interfere with TNFR2 signaling. GSK1995057 inhibits the activation of NF-κB, JNK and MAPK pathways, alleviates apoptosis (apoptosis) and inflammatory responses (inhibiting IL-1β, IL-6, *IL-10, TNF-α), and prevents viability loss of human nucleus pulposus cells. GSK1995057 inhibits the expression of cytokines and neutrophil adhesion molecules in human pulmonary microvascular endothelial cell monolayers, and reduces inflammatory responses and lung injury symptoms in non-human primates. GSK1995057 forms complexes with HAVH autoantibodies, thereby activating TNFR1* and triggering the release of cytokines and IL-8 in human cells. GSK1995057 can be used in research related to intervertebral disc degeneration and acute lung injury .

HY-P99390

Tepoditamab MCLA 117	CD3 Interleukin Related IFNAR TNF Receptor	Inflammation/Immunology Cancer
Tepoditamab (MCLA-117) is a full-length human IgG1 bispecific monoclonal antibody that binds to CLEC12A of myeloid cells and CD3 of cytotoxic T cells. Among others, CLEC12A is a myeloid differentiation antigen. Tepoditamab kills AML leukaemia mother cells and AML leukaemia stem cells, induces T cell-mediated proliferative lysis of AML cells. Tepoditamab induces upto 30-fold T-cell expansion. Tepoditamab results in moderate to strong cytokine (IFNγ, IL-6, IL-8, IL-10, and TNFα) and IFNγ release in human whole blood and PBMC, respectively. Tepoditamab can be used in acute myeloid leukaemia (AML) research .

HY-P991257

MK-1966 1 Publications Verification	Interleukin Related CXCR MHC	Cancer
MK-1966 is an anti-IL-10 antibody. MK-1966 inhibits secretion of cytokines from activated macrophages, production of CC and CXC chemokines, and a TH1 response, down-regulates MHC and costimulatory molecules on dendritic cells (DCs), and induces regulatory T cells. MK-1966 can be used for the research of cancer , such as gastric cancer .

HY-P990561

BT-063	Interleukin Related	Inflammation/Immunology
BT-063 is a humanized antibody expressed in CHO cells, targeting *IL-10*. BT-063 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for BT-063 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P99198

Fletikumab NNC 0109-0012	Interleukin Related	Inflammation/Immunology
Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis .

HY-P991659

SCH708980	Interleukin Related	Infection Inflammation/Immunology
SCH708980 is a humanized monoclonal antibody inhibitor targeting *IL-10*. SCH708980 has anti-immunosuppressive activity. SCH708980 can be used for visceral leishmaniasis, sepsis-associated kidney injury (SAKI) and osteoporosis research .

HY-P990776

Vimekofusp	Interleukin Related	Inflammation/Immunology
Vimekofusp is a recombinant IL-10 fusion protein that targets IL10RA and IL10RB .

HY-P991760

*Anti-IL-10* Antibody (JES3-19F1)**	Interleukin Related	Inflammation/Immunology
Anti-IL-10 Antibody (JES3-19F1) reacts with human IL-10, and is a capture or coating antibody in ELISA applications. Anti-IL-10 Antibody (JES3-19F1) reduces bacterial load in Mycobacterium avium infected mice. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

HY-P992038

*Anti-IL-10RB Antibody*	Interleukin Related	Inflammation/Immunology
Anti-IL-10RB Antibody is an anti-IL-10RB antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992037

*Anti-IL-10Rα Antibody*	Interleukin Related	Inflammation/Immunology
Anti-IL-10Rα Antibody is an anti-IL-10Rα antibody. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992153

Serrumab	Interleukin Related	Inflammation/Immunology
Serrumab is a human monoclonal antibody that counteracts the biochemical and immunological effects of Tityus serrulatus venom. Serrumab inhibits the TsV-induced increase in the production of IL-6, TNFα and *IL-10*. Serrumab also prevents TsV-induced elevations in plasma urea, creatinine, aspartate transaminase and glucose levels, as well as the TsV-induced increase in neutrophil recruitment. Serrumab can be used in research related to envenoming by the Brazilian yellow scorpion .

HY-P992370

HPN601	Interleukin Related IFNAR	Cancer
HPN601 is a protease-activated EpCAM-targeting T-cell engager that binds EpCAM competitively and induces T-cell mediated tumor cell killing. HPN601 binds to EpCAM, CD3e and albumin; albumin binding extends its half-life, while masking groups keep the molecule inert outside the tumor microenvironment. HPN601 significantly reduces the release levels of IFN-γ, IL-2, IL-6 and *IL-10*. HPN601 can be used in research related to cancers such as breast cancer and gastric cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0809

Theophylline Maximum Cited Publications 12 Publications Verification 1,3-Dimethylxanthine; Theo-24	Structural Classification Classification of Application Fields Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Alkaloids Immune System Disorder Other Alkaloids Disease markers Disease Research Fields Source Classification Theaceae Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-N0405

Orientin 5+ Cited Publications	Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	TNF Receptor Interleukin Related
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases *IL-10* level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-113494

Sitostanol 1 Publications Verification Stigmastanol; 24α-Ethyl cholestanol	Human Gut Microbiota Metabolites Classification of Application Fields Guttiferae Other Diseases Hypericum riparium Plants Endogenous metabolite Disease Research Fields Steroids Source Classification	Interleukin Related
Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and *IL-10*. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma .

HY-N6607

Tryptanthrin 5+ Cited Publications	Alkaloids Classification of Application Fields Polygonaceae Plants Polygonum tinctorium Ait. Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-W013579

(S)-(+)-Carvone D-Carvone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Gymnaster koraiensis Other Diseases Umbelliferae Plants Disease Research Fields Source Classification	Environmental Pollutants Apoptosis Caspase Interleukin Related Reactive Oxygen Species (ROS) NOD-like Receptor (NLR) SOD
(S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, *IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic* death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[10] .

HY-N0493

Pectolinarigenin 2 Publications Verification	Structural Classification Flavonoids Classification of Application Fields Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy
Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of *IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR* signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Environmental Pollutants Reactive Oxygen Species (ROS) Interleukin Related
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-N0818

Chikusetsusaponin Iva 2 Publications Verification Calenduloside F	Triterpenes Classification of Application Fields Terpenoids Other Diseases Amaranthaceae Plants Alternanthera philoxeroides (Mart.) Griseb. Disease Research Fields Source Classification	Keap1-Nrf2
Chikusetsusaponin IVa is an orally active protein kinase activator. Chikusetsusaponin IVa binds to YAP with a K_D value of 0.388 mM. Chikusetsusaponin IVa reduces inflammatory mediators (IL-6, *IL-10, COX-2) expression, NO production, promotes ROS* generation, induces Apoptosis, inhibits MAPK, TAZ, and regulates Nrf2, JAK/STAT. Chikusetsusaponin Iva has anti-H9N2 AIV and anti-endometrial cancer activities. Chikusetsusaponin Iva shows anti-inflammatory, hepatoprotective and osteoprotective effects ^[10].

HY-N15135

Arabinoxylan (Medium viscosity)	Structural Classification Polysaccharides Antibiotics Leguminosae Pisum sativum Linn Plants Saccharides Other Antibiotics Source Classification	Interleukin Related Toll-like Receptor (TLR) Fungal
Arabinoxylan Medium viscosity is an orally active Dectin-1 splice variant modulator, glucose absorption inhibitor, and chyme viscosity enhancer. Arabinoxylan Medium viscosity inhibits particulate β-glucan-induced Dectin-1A activation and mildly suppresses Dectin-1B activation. In human dendritic cells stimulated with particulate β-glucan, Arabinoxylan Medium viscosity reduces the production of *IL-10* and TNF-α, and increases the production of IL-4 and IL-23. Arabinoxylan Medium viscosity also supports antifungal immune responses without activating TLR2, TLR4 or TLR5, and does not induce cytokine production when used to stimulate human dendritic cells alone. Arabinoxylan Medium viscosity increases small intestinal chyme viscosity, gets degraded in the large intestine to produce short-chain fatty acids, reduces glucose absorption and insulin response, and improves glucose homeostasis. Arabinoxylan Medium viscosity supports microbial fermentation and the growth of beneficial microbiota in the gastrointestinal tract, prevents bile acid reabsorption, and delays starch digestion. Arabinoxylan Medium viscosity can be used in research related to type 2 diabetes, impaired glucose tolerance, and metabolic syndrome .

HY-N0695

Schisantherin B 1 Publications Verification Gomisin-B; Wuweizi ester-B; Schisantherin-B	Structural Classification Classification of Application Fields Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Inflammation/Immunology Disease Research Fields Source Classification	PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis
Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of *IL-10, and inhibits cell apoptosis*. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .

HY-N0600

Ginsenoside F3	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Araliaceae Source Classification	Interleukin Related IFNAR NF-κB
Ginsenoside F3 is a saponin extracted from the leaves of Panax ginseng with immunoenhancing and antitumor immunostimulatory activities. Ginsenoside F3 upregulates RIPOR2 with a K_d value of 3.77 μM. Ginsenoside F3 enhances NF‑κB activation, upregulates T‑bet and downregulates GATA‑3, increases the production of IL‑2 and IFN‑γ, decreases the production of IL‑4 and *IL‑10*, reverses CD8⁺ T‑cell exhaustion, restores cytokine secretion, and enhances antitumor immunity in a mouse non‑small cell lung cancer model. Ginsenoside F3 can be used for the research of non-small cell lung cancer .

HY-N4087

Platycodin D2 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Source Classification Cancer	Mitophagy Autophagy Ferroptosis Interleukin Related IFNAR Reactive Oxygen Species (ROS)
Platycodin D2 is an orally active triterpenoid saponin found in Platycodon grandiflorum. Platycodin D2 induces mitophagy in cancer cells through NIX, thereby activating the P21/CyclinA2 pathway and promoting cell senescence. Platycodin D2 induces mitochondrial dysfunction, enhances autophagy, inhibits hepatocellular carcinoma cell proliferation, and exhibits anti-tumor activity against multiple cancer cell types. Platycodin D2 promotes mRNA expression of T-bet, GATA-3, Th1 cytokines IL-2 and IFN-γ, and Th2 cytokines IL-4 and *IL-10, enhances splenocyte proliferation, and acts as a vaccine adjuvant with low rabbit red blood cell hemolytic activity. Platycodin D2 induces mitochondrial ROS* production, incomplete autophagy, and ferroptosis to inhibit breast cancer cell proliferation. Platycodin D2 can be used for the research of cancer, inflammation and immunology .

HY-124344

Avenanthramide C	Simple Phenylpropanols Avena sativa Linn. Gramineae Phenylpropanoids Plants Source Classification	Interleukin Related
Avenanthramide C is an orally active avenanthramide that can be isolated from oat seeds. Avenanthramide C decreases the protein expression of cleaved caspase-3 and increases the expression of p-GSK3β(Ser9) and IL-10 levels. Avenanthramide C has the potential for the research of Alzheimer’s disease .

HY-W015892

γ-Hexalactone γ-Caprolactone	Structural Classification Natural Products other families Classification of Application Fields Other Diseases Plants Disease Research Fields Source Classification	Interleukin Related TNF Receptor Insecticide
γ-Hexalactone (γ-Caprolactone) is a gamma-lactone found in ripe fruits. γ-Hexalactone induces DNA damage in human lymphocytes and HepG2 cells, modulates cytokine secretion in human lymphocytes, and reduces recombinant PON1 activity. γ-Hexalactone serves as a dose-dependent oviposition inhibitor against Bactrocera oleae. γ-Hexalactone can be used for the research of Bactrocera oleae pest management .

HY-N14039

Pinus pinaster bark extract	Natural Products Pinaceae Pinus pinaster. Plants Source Classification	Toll-like Receptor (TLR) Interleukin Related
Pinus pinaster bark extract is extracted from the bark of pine bark with antioxidant, anti-inflammatory and neuroprotective effects. Pinus pinaster bark extract increases toll-like receptor (TLR) activity, inducing production of *IL-10* .

HY-N8249

Cynandione A	Apocynaceae Phenols Polyphenols Plants Cynanchum boudieri H. Lév. & Vaniot Source Classification	nAChR Interleukin Related
Cynandione A is an acetophenone that can be isolated from Cynanchum Wilfordii Radix. Cynandione A protects hepatocytes and cortical neurons from toxicity and improves neurological deficits in a rat model of cerebral ischemia. On the other hand, cynandione A has significant anti-inflammatory effects and inhibits inflammation by activating macrophage α7 nAChR and IL-10 expression .

HY-N1940

β-Anhydroicaritin 3 Publications Verification Cycloicaritin	Flavonols Flavonoids Classification of Application Fields Plants Burseraceae Inflammation/Immunology Disease Research Fields Boswellia carterii	Interleukin Related TNF Receptor MMP
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-B0809A

Theophylline monohydrate 5+ Cited Publications 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor
Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809R

Theophylline (Standard) 5+ Cited Publications 1,3-Dimethylxanthine(Standard); Theo-24 (Standard)	Alkaloids Immune System Disorder Classification of Application Fields Disease markers Camellia sinensis (L.) O. Ktze. Plants Endogenous metabolite Disease Research Fields Source Classification Theaceae Cancer	Reference Standards Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite
Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-N7697A

Chitopentaose pentahydrochloride	Microorganisms Classification of Application Fields Disease Research Fields Inflammation/Immunology Saccharides Source Classification	Others
Chitopentaose pentahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitopentaose pentahydrochloride is a substrate of gene encoding chitinase B (FjchiB) .

HY-N6607R

Tryptanthrin (Standard)	Alkaloids Structural Classification Polygonaceae Plants Polygonum tinctorium Ait. Indole Alkaloids Source Classification	Reference Standards Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related
Tryptanthrin (Standard) is the analytical standard of Tryptanthrin. This product is intended for research and analytical applications. Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N2492

(E)-Methyl 4-coumarate Methyl trans-p-coumarate	Infection Monophenols Classification of Application Fields Morinda citrifolia Linn. Rubiaceae Other Phenylpropanoids Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis Interleukin Related GSK-3 Parasite
(E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing *IL-10* and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection .

HY-N4267

Yangambin	Cardiovascular Disease Structural Classification other families Classification of Application Fields Lignans Phenylpropanoids Plants Disease Research Fields Source Classification	Calcium Channel Platelet-activating Factor Receptor (PAFR) UGT Leukotriene Receptor TNF Receptor PGE synthase Interleukin Related
Yangambin is a PAF receptor antagonist and UGT1A1/UGT1A3 inhibitor, with an IC₅₀ of 29.7 μM and a K_i of 17.1 μM against human UGT1A1, and an IC₅₀ of 56.5 μM and a K_i of 66.8 μM against human UGT1A3. Yangambin blocks PAF-mediated responses, inhibits LTB₄-mediated neutrophil infiltration, and suppresses inflammatory events and anaphylactic contraction. Yangambin acts as a central nervous system inhibitor to reduce spontaneous activity, and also exhibits analgesic, anticonvulsant, antileishmanial, vasodilatory and hypotensive effects. Yangambin blocks voltage-gated Ca ²⁺ channels, reduces the production of NO, TNF-α, IL-6 and PGE2 in cells, increases the production of *IL-10*, and exerts a protective effect against cardiovascular injury. Yangambin can be used in research related to allergies, cutaneous leishmaniasis, central nervous system diseases and cardiovascular diseases .

HY-N7697C

Chitohexaose hexahydrochloride	Structural Classification Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Saccharides Source Classification	Toll-like Receptor (TLR) Interleukin Related Reactive Oxygen Species (ROS)
Chitohexaose hexahydrochloride is a small molecular polysaccharide. Chitohexaose hexahydrochloride inhibits the binding of AgW to TLR4. Chitohexaose hexahydrochloride upregulates *IL-10, inhibits LPS-induced upregulation of ROS, induces alternative activation of macrophages/monocytes, and suppresses LPS-induced production of TNF-α, IL-1β* and IL-6. Chitohexaose hexahydrochloride reverses the mortality of mice challenged with APAP or LPS. Chitohexaose hexahydrochloride can be used in research related to Acetaminophen (HY-66005)-induced hepatotoxicity and endotoxemia .

HY-N7697D

Chitoheptaose heptahydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Reactive Oxygen Species (ROS)
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-N0405R

Orientin (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards TNF Receptor Interleukin Related
Orientin (Standard) is the analytical standard of Orientin. This product is intended for research and analytical applications. Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases IL-10 level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-N0976

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Structural Classification Natural Products Classification of Application Fields Leguminosae Derris robusta Plants Inflammation/Immunology Disease Research Fields Source Classification	Interleukin Related Wnt
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

HY-W553071

Cytoxazone	Natural Products Microorganisms Source Classification	Interleukin Related
Cytoxazone is a cytoK_ine regulator found in Streptornyces sp. RK95-31. Cytoxazone inhibits the production of IL-4 and IL-10 induced by Pokeween mitogen (PWM) at 6.25-25 μg/mL, but does not inhibit the production of GM-CSF induced by PWM .

HY-113494R

Sitostanol (Standard) Stigmastanol (Standard); 24α-Ethyl cholestanol (Standard)	Structural Classification Human Gut Microbiota Metabolites Microorganisms Guttiferae Hypericum riparium Plants Endogenous metabolite Steroids Source Classification	Reference Standards Interleukin Related
Stigmastanol (Standard) is the analytical standard of Stigmastanol. This product is intended for research and analytical applications. Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and *IL-10*. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma .

HY-N15347

Talaromyketide B	Natural Products Microorganisms Source Classification	NF-κB p38 MAPK Interleukin Related TNF Receptor NO Synthase COX
Talaromyketide B is a polyketide compound with anti-inflammatory activity, discovered in the soil bacterium Talaromyces sp. KYS-41. Talaromyketide B inhibits the activation of the NF-κB and MAPK signaling pathways and dose-dependently suppresses pro-inflammatory cytokines, such as IL-1β, IL-6, IL-10, and TNF-α, as well as the transcriptional activity of inflammatory mediators, including iNOS and COX-2. Talaromyketide B holds potential for research in the fields of immunity and inflammatory diseases .

HY-B0809B

Theophylline sodium acetate 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-N0695R

Schisantherin B (Standard) Gomisin-B (Standard); Wuweizi ester-B (Standard); Schisantherin-B (Standard)	Structural Classification Lignans Phenylpropanoids Plants Schisandraceae Schisandra chinensis (Turcz.) Baill. Source Classification	Reference Standards PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis
Schisantherin B (Gomisin-B) (Standard) is the analytical standard of Schisantherin B. This product is intended for research and analytical applications. Schisantherin B is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of *IL-10, and inhibits cell apoptosis*. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression.

HY-W013579R

(S)-(+)-Carvone (Standard) D-Carvone (Standard)	Ketones, Aldehydes, Acids Gymnaster koraiensis Umbelliferae Plants Source Classification	Reference Standards Others
(S)-(+)-Carvone (Standard) is the analytical standard of (S)-(+)-Carvone. This product is intended for research and analytical applications. (S)-(+)-Carvone is an orally active natural product. (S)-(+)-Carvone increases the activity of antioxidant enzymes (SOD, CAT) and ROS, reduces the levels of oxidative stress markers (MDA, AChE), reduces the secretion of proinflammatory cytokines (IL-1β, IL-4, IL-6, *IL-10), and downregulates NLRP3. (S)-(+)-Carvone increases the activities of caspase-8, -9 and -3. (S)-(+)-Carvone induces apoptotic* death. (S)-(+)-Carvone has antimanic-like effect, liver protection and anticancer activity against skin cancer. (S)-(+)-Carvone improves memory and arthritis ^[10] .

HY-N2492R

(E)-Methyl 4-coumarate (Standard) Methyl trans-p-coumarate (Standard)	Structural Classification Monophenols Morinda citrifolia Linn. Rubiaceae Other Phenylpropanoids Phenols Phenylpropanoids Plants Source Classification	Reference Standards Apoptosis Parasite Interleukin Related GSK-3
(E)-Methyl 4-coumarate (Standard) is the analytical standard of (E)-Methyl 4-coumarate (HY-N2492). This product is intended for research and analytical applications. (E)-Methyl 4-coumarate (Methyl 4-hydroxycinnamate) is a phenolic compound and derivative of Cinnamic acid (HY-N0610A). (E)-Methyl 4-coumarate can be found in several plants, such as the leaves of Allium cepa and Morinda citrifolia L. (E)-Methyl 4-coumarate, when combined with Carnosic acid (HY-N0644), induces Apoptosis. (E)-Methyl 4-coumarate inhibits GSK3β activity and modulates inflammatory cytokine levels (increasing *IL-10* and decreasing IL-4). (E)-Methyl 4-coumarate combined with Carnosic acid exhibits anticancer effects against acute myeloid leukemia. (E)-Methyl 4-coumarate ameliorates Plasmodium berghei NK65 infection .

HY-N0493R

Pectolinarigenin (Standard)	Structural Classification Flavonoids Flavones Campylotropis hirtella (Franch.) Schindl. Phenols Polyphenols Plants Compositae Source Classification	Reference Standards COX Lipoxygenase NF-κB p38 MAPK ERK HIF/HIF Prolyl-Hydroxylase Keap1-Nrf2 PI3K Apoptosis Autophagy
Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is an orally active dual inhibitor of COX-2/5-LOX with anti-inflammatory, antioxidant, antitumor and neuroprotective activities. Pectolinarigenin exerts neuroprotective and anti-inflammatory effects on astrocyte inflammation via the NFκB and MAPK pathways. Pectolinarigenin inhibits LPS-induced phosphorylation of ERK1/2, N-FκB and p38MAPK, directly inhibits the enzymatic activity or binding of COX-2, 5-LOX and HIF-1α, and reduces the level of XIAP. Pectolinarigenin modifies Keap1 to promote nuclear accumulation of Nrf2, induces ARE-mediated antioxidant enzyme expression, and possesses direct free radical scavenging activity. Pectolinarigenin reduces the release of NO, proinflammatory mediators and leukotrienes, and increases the level of *IL-10. Pectolinarigenin induces G₂/M cell cycle arrest, apoptosis (Apoptosis) and autophagy (Autophagy) via the PI3K/AKT/mTOR* signaling pathway. Pectolinarigenin reduces renal crystal deposition and inhibits melanin synthesis. Pectolinarigenin inhibits inflammation and alleviates allergy in mouse models of inflammation. Pectolinarigenin alleviates renal injury, inflammation and oxidative stress in mice by inhibiting HIF-1α activity. Pectolinarigenin can be used for the research of neurodegenerative diseases, inflammatory/allergic diseases, calcium oxalate nephrocalcinosis, gastric cancer, melasma, post-inflammatory diseases and chloasma.

HY-N18367

Lemairamin Wgx-50	Zanthoxylum bungeanum Maxim. Structural Classification Simple Phenylpropanols Rutaceae Phenylpropanoids Plants Source Classification	nAChR Interleukin Related Akt
Lemairamin (Wgx-50) is a hydroxylamine compound. Lemairamin can be isolated from the pericarps of the Zanthoxylum plants. Lemairamin activates α7nAChR, stimulates the expression of *IL-10* and POMC. Lemairamin shows a decrease in Akt. Lemairamin attenuates DSS-induced intestinal inflammation. Lemairamin alleviates pain hypersensitivity .

HY-N17685

Pseudoginsenoside RT4	Structural Classification Panax vietnamensis Ha & Grushv. Plants Saccharides Araliaceae Monosaccharides Source Classification	Interleukin Related
Pseudoginsenoside RT4 is an orally active tetracyclic triterpenoid. Pseudoginsenoside RT4 can be isolated from Panax pseudoginseng subsp. Himalaicus. Pseudoginsenoside RT4 reduces the levels of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β), boosts the levels of *IL-10*. Pseudoginsenoside RT4 modulates the composition of gut microbiota. Pseudoginsenoside RT4 shows anti-inflammatory effects. Pseudoginsenoside RT4 can be used in the study of ulcerative colitis .

HY-N9980

Antcin K	Structural Classification Microorganisms Steroids Source Classification	PI3K Akt NF-κB p38 MAPK AP-1
Antcin K is a selective inhibitor targeting the PI3K/Akt, NF-κB, MEK1/2-ERK, p38 and AP-1 pathways. Antcin K upregulates *IL-10* expression, thereby inhibiting the production of pro-inflammatory factors, blocking monocyte adhesion, reducing tissue damage, and promoting myogenesis. Antcin K has significant anti-inflammatory, anti-damage and tissue protective activities. Antcin K is mainly used in the research of inflammation-related diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury .

HY-N19801

N-Palmitoyl-D-glucosamine	Structural Classification Natural Products Microorganisms Source Classification	Toll-like Receptor (TLR) NF-κB Interleukin Related TNF Receptor
N-Palmitoyl-D-glucosamine is an orally active TLR4 antagonist. N-Palmitoyl-D-glucosamine stably binds MD-2 with, preventing LPS-induced NF-κB signaling, decreases pro-inflammatory cytokines (IL-1β, TNF-α, and IL-6), increases anti-inflammatory *IL-10* and IL-1rα, and normalizes miR-20a-5p, miR-106a-5p, and miR-27a-3p levels. N-Palmitoyl-D-glucosamine decreases allodynia and prevents myelino-axonal degeneration of peripheral nerves. N-Palmitoyl-D-glucosamine can be used for the researches of keratitis and peripheral neuropathy .

Recombinant Proteins Recommended:

IL-10

Species:	Virus (1) Human (16) Rhesus Macaque (2) Rat (4) Mouse (9) Cynomolgus (2) Cat (1) Canine (1) Pig (2)
Tag:	His (16) Tag Free (13) Avi (6) Fc (10)
Source:	HEK293 (23) CHO (3) E. coli (12)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70517

	IL-10 Protein, Mouse Maximum Cited Publications 6 Publications Verification Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. IL-10 Protein, Mouse is the recombinant mouse-derived IL-10 protein, expressed by E. coli , with tag free.

HY-P700244AF

	*Animal-Free IL-10* Protein, Pig (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. Animal-Free IL-10 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P73152

	IL-10 Protein, Feline	Cat	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Feline is the recombinant IL-10 protein, expressed by E. coli , with tag free.

HY-P700188AF

	*Animal-Free IL-10* Protein, Mouse (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P73154

	IL-10 Protein, Pig 1 Publications Verification	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Pig is the recombinant pig-derived IL-10 protein, expressed by E. coli , with tag free.

HY-P70751

	IL-10 Protein, Human (HEK293) 1 Publications Verification Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with tag free.

HY-P7030

	IL-10 Protein, Human 3 Publications Verification rHuIL-10; CSIF	Human	E. coli
	IL-10 Protein, Human is an anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098

	IL-10 Protein, Rat rRtIL-10; CSIF	Rat	E. coli
	IL-10 Protein, Rat is an immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7030A

	IL-10 Protein, Human (CHO) 4 Publications Verification rHuIL-10; CSIF	Human	CHO
	IL-10 Protein, Human (CHO) is a CHO cell derived anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098A

	IL-10 Protein, Rat (CHO) 2 Publications Verification rRtIL-10; CSIF	Rat	CHO
	IL-10 Protein, Rat (CHO) is a CHO cell derived immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7074A

	IL-10 Protein, Mouse (CHO) rMuIL-10; CSIF	Mouse	CHO
	IL-10 Protein, Mouse (CHO) is a potent CHO cell derived anti-inflammatory cytokine results in increased immune-mediated demyelination in mice infected with a neurotropic coronavirus.

HY-P79268

	IL-10 Protein, Canine IL10; CSIF; CSIFMGC126450; Cytokine synthesis inhibitory factor; IL10A; IL-10MGC126451; interleukin-10; TGIF; Interleukin 10	Canine	E. coli
	IL-10 is the most important cytokine that inhibits pro-inflammatory responses and limits excessive immune responses in various autoimmune diseases. It belongs to the type 2 cytokine superfamily. IL-10 plays an important role in transmitting information, activating and regulating immune cells, mediating T and B cell activation, proliferation and differentiation, and in inflammatory responses. IL-10 can promote the proliferation and activation of CD8T⁺ cells, enhancing anti-tumor capabilities. IL-10 Protein, Canine is the recombinant canine-derived IL-10 protein, expressed by E. coli , with tag free.

HY-P700740

	IL-10 Protein, Cynomolgus (HEK293, His) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Cynomolgus	HEK293
	IL-10 Protein, a key immune regulatory cytokine, centrally modulates immune responses. IL-10 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P78460

	IL-10 Protein, Human (HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P78144

	IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag.

HY-P700097AF

	*Animal-Free IL-10* Protein, Human (His)** B-TCGF; CSIF; TGIF	Human	E. coli
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Human (His) is the recombinant human-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. This product is for cell culture use only.

HY-P73153

	IL-10 Protein, Human (HEK293, His) 1 Publications Verification Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag.

HY-P79362

	IL-10 Protein, Virus Viral interleukin-10 homolog; BCRF1; vIL-10; 20 kDa protein; Protein BCRF1; Interleukin 10	Virus	E. coli
	IL-10 Protein critically masks infected cells for immune evasion by down-regulating the host TAP1 gene, hindering peptide transport into the endoplasmic reticulum and loading onto MHC class I molecules. IL-10 also inhibits IFN-gamma synthesis and exists as a homodimer. IL-10 Protein, Virus is the recombinant Virus-derived IL-10 protein, expressed by E. coli , with tag free.

HY-P700741

	IL-10R alpha Protein, Cynomolgus (HEK293, His) IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha	Cynomolgus	HEK293
	IL-10R alpha Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-10R alpha protein, expressed by HEK293, with C-His labeled tag.

HY-P78464

	IL-10R alpha Protein, Human (HEK293, His-Avi) IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a His and Avi tag at the C-terminus.

HY-P70692

	IL-10R alpha Protein, Human (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P700639

	IL-10R alpha Protein, Human (HEK293) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P705122

	IL-10R alpha Protein, Human (Biotinylated, HEK293, Fc-Avi) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293

HY-P75825

	IL-10R alpha Protein, Mouse (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R1; CD210; IL10RA	Mouse	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Mouse (HEK293, Fc) is expressed by HEK 293cells with a hFc tag at the C-terminus.

HY-P72599

	IL-10R beta Protein, Human (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a 6*His tag at the C-terminus.

HY-P74837

	IL-10R beta Protein, Mouse (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a His tag at the C-terminus.

HY-P76414

	IL-10R beta Protein, Rat (HEK293, Fc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Rat	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and consists of 351 amino acids (M1-V351) with a Fc tag at the C-terminus.

HY-P76987

	IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines.IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a -hFc tag at the C-terminus.

HY-P76988

	IL-10R alpha Protein, Rhesus Macaque (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Rhesus Macaque (HEK293, His) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a His tag at the C-terminus.

HY-P74838

	IL-10R beta Protein, Mouse (HEK293, hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, hFc) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a hFc tag at the C-terminus.

HY-P74839

	IL-10R beta Protein, Human (HEK293, His-hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Human (HEK293, His-hFc) is expressed by HEK293 cells and with a His and -hFc tag at the C-terminus.

HY-P701062

	*IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P700872

	*IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P73892

	IL-20 Protein, Rat Cytokine Zcyto10; IL10D; IL20; Interleukin-20	Rat	E. coli
	IL-20 Protein, a pivotal immune regulatory cytokine, critically modulates immune responses. IL-20 Protein, Rat is the recombinant rat-derived IL-20 protein, expressed by E. coli , with tag free.

HY-P77964

	IL-20 Protein, Mouse (HEK293, His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-His labeled tag.

HY-P700198AF

	Animal-Free IL-20 Protein, Mouse (His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	E. coli
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. Animal-Free IL-20 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-20 protein, expressed by E. coli , with C-His labeled tag.This product is for cell culture use only.

HY-P77963

	IL-20 Protein, Mouse (HEK293, Fc) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P705904

	IL-22 Protein, Human (HEK293, Fc) Interleukin-22; IL22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF	Human	HEK293
	IL-22 protein is a cytokine that regulates tissue responses during inflammation and contributes to epithelial cell regeneration to maintain barrier function and prevent tissue damage. IL-22 Protein, Human (HEK293, Fc) is the recombinant human-derived IL-22 protein, expressed by HEK293, with C-hFc labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-130321S

Lauroyl-L-carnitine-d3 chloride
Lauroyl-L-carnitine-d₃ (chloride) is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene *IL-10*. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-130321S1

Lauroyl-L-carnitine-d9 chloride
Lauroyl-L-carnitine-d₉ chloride is the deuterium labeled Lauroyl-L-carnitine chloride (HY-130321). Lauroyl-L-carnitine chloride is an orally active metabolite. Lauroyl-L-carnitine chloride significantly reverses the decrease in its target gene *IL-10*. Lauroyl-L-carnitine chloride alleviates Crohn' s-like colitis .

HY-B0809S1

Theophylline-d3

Theophylline-d₃ is deuterated labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-W777138

rel-(1S,2R)-Dihydro bupropion-d9

rel-(1S,2R)-Dihydro bupropion-d₉ is the deuterium labeled rel-(1S,2R)-Dihydro bupropion (HY-178240). rel-(1S,2R)-Dihydro bupropion is a metabolite of bupropion. rel-(1S,2R)-Dihydro bupropion can promote endogenous IL-10 production and inhibit Th1 cytokines (IL-12 and TNF-α). rel-(1S,2R)-Dihydro bupropion can induce immune response transition from Th1 to Th2. rel-(1S,2R)-Dihydro bupropion can be used for research on inflammatory conditions .

HY-W745349

rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride

rel-(1S,2R)-Dihydro bupropion-d₉ hydrochloride is the deuterium labeled rel-(1S,2R)-Dihydro bupropion hydrochloride (HY-178240). rel-(1S,2R)-Dihydro bupropion is a metabolite of bupropion. rel-(1S,2R)-Dihydro bupropion can promote endogenous IL-10 production and inhibit Th1 cytokines (IL-12 and TNF-α). rel-(1S,2R)-Dihydro bupropion can induce immune response transition from Th1 to Th2. rel-(1S,2R)-Dihydro bupropion can be used for research on inflammatory conditions .

HY-143683S

Theophylline-13C2,d6

Theophylline- ¹³C₂,d₆ (1,3-Dimethylxanthine- ¹³C₂,d₆) is the deuterium labeled and ¹³C-labeled Theophylline (HY-B0809). Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

Host:	Mouse (11) Rabbit (5)
Reactivity:	Human (15) mouse (1) rat (1) Rat (4) Mouse (3)
Application:	IHC-P (7) ICC/IF (8) IP (1) WB (8) FC (9) ELISA (8)
Isotype:	IgG (5) IgG1 (9) IgG2a (2)
Conjugation:	Non-conjugated (16) Biotin (3)
Clonality:	Polyclonal (1) Monoclonal (8) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (11)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86311

	IL-10 Antibody (YA6003) IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IL-10 Antibody (YA6003) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

HY-P85219

	IL-10 Antibody (YA4911) IL10; Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF	WB, ICC/IF, FC	Human, Mouse
	IL-10 Antibody (YA4911) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to IL-10.

HY-P89929

	IL-10 Antibody (YA9273)	WB, FC, ELISA	mouse, rat
	IL-10 Antibody (YA9273) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL-10.

HY-P84952

	IL-10 Antibody (YA4644) Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 白介素10	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	IL-10 Antibody (YA4644) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

HY-P81113

	IL-10 Antibody (YA3521) Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 白介素10	WB, ICC/IF, FC	Human
	IL-10 Antibody (YA3521) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IL-10.

HY-P84553

	CD210 Antibody (YA4250) IL10RA; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1	ICC/IF, FC, ELISA	Human
	CD210 Antibody (YA4250) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD210.

HY-P84553A

	CD210 Antibody (YA4250)(PBS only) IL10RA; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1	ICC/IF, FC, ELISA	Human
	CD210 Antibody (YA4250) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD210.

HY-P84509

	IL10RB Antibody (YA4206) CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2	WB, FC, ELISA	Human, Rat
	IL10RB Antibody (YA4206) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL10RB.

HY-P84510

	IL10RB Antibody (YA4207) CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2	ICC/IF, FC, ELISA	Human
	IL10RB Antibody (YA4207) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL10RB.

HY-P84509A

	IL10RB Antibody (YA4206)(PBS only) CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2	WB, FC, ELISA	Human, Rat
	IL10RB Antibody (YA4206) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL10RB.

HY-P84510A

	IL10RB Antibody (YA4207)(PBS only) CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2	ICC/IF, FC, ELISA	Human
	IL10RB Antibody (YA4207) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL10RB.

HY-P88511

	IL20 Antibody (YA8195) IL-20; IL10D; ZCYTO10	IHC-P	Human
	IL20 Antibody (YA8195) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL20.

HY-P81240

	IL-19 Antibody IL-19; MDA1; NG.1; ZMDA1; IL-10C	WB, IHC-P	Human
	IL-19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-19.

HY-P88511A

	IL20 Antibody (YA8195)(PBS only) IL-20; IL10D; ZCYTO10	IHC-P	Human
	IL20 Antibody (YA8195) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to IL20.

HY-P88206

	IL24 Antibody (YA7890) C49A; FISP; IL10B; MDA7; MOB5; ST16	IHC-P	Human
	IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.

HY-P88206A

	IL24 Antibody (YA7890)(PBS only) C49A; FISP; IL10B; MDA7; MOB5; ST16	IHC-P	Human
	IL24 Antibody (YA7890) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to IL24.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-A0103

Xanthan gum		Emulsifiers Thickeners
Xanthan gum interacts with gelatin (HY-Y1365) via hydrogen bonds, thereby increasing the viscosity and stability of the hydrogel while promoting cell growth and creating a microenvironment conducive to cell differentiation ^[1][2]. Xanthan gum induces pro-inflammatory responses by increasing the levels of TNF-α, IL-6, and *IL-10*. Xanthan gum can be used for inflammation and immunology research .

HY-150743

ODN 2395		CpG ODNs
ODN 2395 is a C class oligodeoxynucleotide and can be used as vaccine adjuvant. ODN 2395 is also a TLR9 agonist. ODN 2395 can be used in the research of immunological vaccines. Sequence: 5'-tcgtcgttttcggcgc:gcgccg-3' (Note: The bases are phosphorothioate; ODN 2395 contains the partial palindromic sequence cggcgc:gcgccg) .

HY-174646

*Human IL10* mRNA**		mRNA Interleukin & Receptors
Human IL10 mRNA is the messenger ribonucleic acid that encodes human IL-10. The expression of IL-10 mRNA is highly inducible and cell type-specific.

HY-177608

*Rat IL10* mRNA**		mRNA
Rat IL-10 mRNA encodes interleukin-10 (IL-10). IL-10 is expressed in tissues/cells such as hepatic stellate cells and is involved in physiological processes including liver fibrosis.

HY-RS06671

Il10 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06670

IL10 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL10 Human Pre-designed siRNA Set A contains three designed siRNAs for IL10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06672

Il10 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-160040

Cobitolimod		Antisense Oligonucleotides
Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod suppresses Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-174620

Human IL22 mRNA		mRNA Interleukin & Receptors
Human IL22 mRNA encodes the human interleukin 22 (IL22) protein, a member of the IL10 family of cytokines that mediate cellular inflammatory responses. IL22 functions in antimicrobial defense at mucosal surfaces and in tissue repair. It also has pro-inflammatory properties and plays a role in in the pathogenesis of several intestinal diseases.

HY-160040A

Cobitolimod sodium		Antisense Oligonucleotides
Cobitolimod sodium is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod sodium inhibits Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-RS17431

Il10ra Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Il10ra Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il10ra gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06674

IL10RB Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL10RB Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS23886

Il10ra Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Il10ra Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10ra gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS06673

IL10RA Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
IL10RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-174659

Human IFNL2 mRNA		mRNA Interferon & Receptors
Human IFNL2 mRNA encodes the human interferon lambda 2 (IFNL2) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL2 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174660

Human IFNL1 mRNA		mRNA Interferon & Receptors
Human IFNL1 mRNA encodes the human interferon lambda 1 (IFNL1) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL1 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174629

Human IL19 mRNA		mRNA Interleukin & Receptors
Human IL19 mRNA encodes the human interleukin 19 (IL19) protein, a cytokine that belongs to the IL10 cytokine subfamily. IL19 may play some important roles in inflammatory responses.

HY-174614

Human IL26 mRNA		mRNA Interleukin & Receptors
Human IL26 mRNA encodes the human interleukin 26 (IL26) protein, a member of the IL10 family of cytokines. IL26 is thought to contribute to the transformed phenotype of T cells after infection by herpesvirus samimiri.

HY-174657

Human IFNLR1 mRNA		mRNA Interferon & Receptors
Human IFNLR1 mRNA encodes the human interferon lambda receptor 1 (IFNLR1) protein, a member of the class II cytokine receptor family. IFNLR1, interleukine 10 receptor and beta (IL10RB) form a receptor complex which has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29).

HY-174645

*Human IL10RA mRNA*		mRNA Interleukin & Receptors
Human IL10RA mRNA encodes the human interleukin 10 receptor subunit alpha (IL10RA) protein, a receptor for interleukin 10. IL10RA been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. It is also reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway.

HY-174658

Human IFNL3 mRNA		mRNA Interferon & Receptors
Human IFNL3 mRNA encodes the human interferon lambda 3 (IFNL3) protein, a cytokine distantly related to type I interferons and the IL-10 family. IFNL3 plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.

HY-174615

Human IL24 mRNA		mRNA Interleukin & Receptors
Human IL24 mRNA encodes the human interleukin 24 (IL24) protein, a member of the IL10 family of cytokines. IL24 can induce apoptosis selectively in various cancer cells.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

IL-10

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
Products