2 Results for "

IL-15Rα

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "IL-15Rα" in MCE Product Catalog:

  • Isoforms Recommended:
Ordesekimab
Ordesekimab
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Cat. No.: HY-P99410
CAS No.: 879293-15-9
Synonyms: AMG 714; PRV-015

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ordesekimab (AMG 714; PRV-015) is a fully human IgG1κ anti-IL-15 (Interleukin Related) monoclonal antibody. The binding of Ordesekimab to IL-15 inhibits the interaction of IL-15 with the IL-2Rβ and common γ chain of the IL-15 receptor complex, but not with the IL-15Rα chain. Ordesekimab has the potential for study of nonresponsive celiac disease (NRCD) .
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Neoprzewaquinone A
Neoprzewaquinone A
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Cat. No.: HY-N3201
CAS No.: 630057-39-5
Category:  

Labiatae Terpenoids Samanea saman (Jacq.) Merr. Other Diseases Diterpenoids Plants Disease Research Fields

Target:  

Others

Neoprzewaquinone (NEO) is an orally active phenanthraquinone derivative isolated from Salvia miltiorrhiza Bunge. Neoprzewaquinone A inhibits IL-15Rα, blocks the ROCK2/STAT3 pathway to impair the migration and invasion abilities of triple-negative breast cancer cells; induces apoptosis of hepatocellular carcinoma cells by inhibiting the PI3K-AKT pathway; suppresses LPS-induced inflammation via binding to TLR4/MD2, and inhibits IL-15-induced proliferation, migration and phagocytosis of microglial cells; protects osteoblasts from mitochondrial dysfunction and apoptosis in diabetic osteoporosis by activating PRKD2 and the ELF5/PRKD2/PI3K/AKT/mTOR axis. Neoprzewaquinone A can be used in the research of diseases including rheumatoid arthritis, hepatocellular carcinoma, diabetic osteoporosis and triple-negative breast cancer .
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