3 Results for "

IL11 signalling

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "IL11 signalling" in MCE Product Catalog:

Cat. No.: HY-P991488

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

BI-765423 is a selective monoclonal antibody inhibitor targeting IL-11. BI-765423 blocks IL-11-mediated signaling, inhibits fibroblast activation, and can extend the healthy lifespan of mammals, counteract cellular senescence in human cells, and alleviate inflammatory aging-related pathological processes. BI-765423 is primarily used in research on fibrotic diseases such as idiopathic pulmonary fibrosis (IPF) .
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Cat. No.: HY-P991487

Research Areas:  

Inflammation/Immunology

LASN01 is a humanized antibody targeting IL-11R, with a Kd of 37 pM. LASN01 blocks the IL-11 signaling pathway via IL-11Rα, and inhibits the phosphorylation of STAT3 and ERK, as well as the expression of pro-inflammatory cytokines, hyaluronic acid, procollagen and fibrotic markers. LASN01 can be used in studies related to thyroid eye disease .
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Cat. No.: HY-P991219
Synonyms: EnX209

Research Areas:  

Inflammation/Immunology

Anti-IL11RA Antibody (X209) (EnX209) is a human-derived IgG4, κ-type antibody inhibitor targeting IL11RA, with a KD of 6 nM. Anti-IL11RA Antibody (X209) blocks the IL11RA signaling pathway, inhibits ERK-dependent activation, and reduces the activation level of ERK1/2. Anti-IL11RA Antibody (X209) exerts a protective effect against fibrosis. Anti-IL11RA Antibody (X209) is applicable to studies related to liver fibrosis, cardiac fibrosis and other related conditions. Recommended isotype control: Human IgG4 kappa, Isotype Control (HY-P99003) .
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