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Results for "

IgG1λ

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) CD20 (1) CD38 (1) CD47 (1) CD73 (2) CMV (1) Complement System (1) CTLA-4 (1) Fc Receptor (FcR) (2) Ferroptosis (1) HBV (2) HIV (1) Interleukin Related (3) PCSK9 (1) PD-1/PD-L1 (1) Reactive Oxygen Species (ROS) (1) SARS-CoV (2) Sodium Channel (1) TGF-β Receptor (1) TNF Receptor (3) Transferrin Receptor (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (9) Infection (5) Inflammation/Immunology (23) Metabolic Disease (2)

Inhibitors & Agonists

Inhibitory Antibodies

Antibodies

Targets Recommended: Human leukocyte immunoglobulin (Ig)-like receptors (LILR) VISTA

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-P9952

Belimumab 5 Publications Verification LymphoStat B	TNF Receptor CD20	Inflammation/Immunology Cancer
Belimumab (LymphoStat B) is a humanized *IgG1λ* monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research ^[1] . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.

HY-P990006

Duvakitug TEV-48574; SAR-447189; TEV-574	TNF Receptor	Inflammation/Immunology
Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to *TNFSF15*/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) ^[1] .

HY-P99322

Tesidolumab LFG316; Anti-Human C5 Recombinant Antibody	Complement System	Inflammation/Immunology
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex ^[1].

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV ^[1].

HY-P990281

Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3)	Interleukin Related	Inflammation/Immunology
Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis ^[1] .

HY-P99039

Oleclumab 1 Publications Verification MEDI9447	CD73	Cancer
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity ^[1] .

HY-P99588

Stamulumab 1 Publications Verification MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research ^[1] .

HY-P99730

Mezagitamab 1 Publications Verification TAK-079	CD38 Apoptosis	Inflammation/Immunology Cancer
Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) ^[1] .

HY-P990015

Tobevibart VIR-3434	HBV	Infection
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P9S0056

*Human IgG1* (L234A/L235A) lambda2, Isotype Control**	Fc Receptor (FcR)	Inflammation/Immunology
Human IgG1 (L234A/L235A) lambda2, Isotype Control, is a human monoclonal antibody that serves as an isotype control for human IgG1λ antibody.

HY-P99102

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

HY-P99103

Bebtelovimab LY-3853113; LY-COV1404	SARS-CoV	Infection
Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC₅₀ value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy ^[1] .

HY-P991381

JST-TfR09 PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) ^[1] .

HY-P990911

Crebankitug ZB-168	Interleukin Related	Inflammation/Immunology
HY-P990911 is an IL7R-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P991717

Sunakiment AZD-8630	Interleukin Related	Inflammation/Immunology Cancer
Sunakiment is a humanized IgG1λ monoclonal antibody inhibitor targeting Thymic stromal lymphopoietin (TSLP). Sunakiment can be used for inflammatory and immune system disorders like ulcerative colitis, rheumatoid arthritis and allergy and cancers research ^[1] .

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research ^[1].

HY-P990014

Danburstotug IMC-001; STI-3031	PD-1/PD-L1	Inflammation/Immunology Cancer
Danburstotug (IMC-001) is an IgG1-lambda anti-CD274 (PDL1, B7 homologue 1, B7H1) human monoclonal antibody. Danburstotug also is immunostimulant and antineoplastic ^[1].

HY-P99871

Ebronucimab AK102	PCSK9	Others
Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells ^[1].

HY-145641

Crexavibart BMS-986413; C-144-LS	SARS-CoV	Infection
Crexavibart (BMS-986413; C-144-LS) is an IgG1_λ2 antibody that targets the SARS-CoV2 spike (S) glycoprotein receptor-binding domain ^[1].

HY-P990259

Anti-Mouse CD96 Antibody (3.3)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma ^[1] .

HY-P990922

Indenebart MEDI-1341; TAK-341	Sodium Channel	Inflammation/Immunology
HY-P990922 is an SNCA-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990924

Libevitug	HBV	Inflammation/Immunology
HY-P990924 is an HBV-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990971

Atenastobart	TNF Receptor	Inflammation/Immunology
HY-P990971 is an TNFRSF9-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990900

Ansipastobart	CD73	Inflammation/Immunology
HY-P990900 is an NT5E-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990899

Amostomig	CD47	Inflammation/Immunology
HY-P990899 is an CD274/CD47-targeting IgG1λ2 type humanized antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P991959

JMW-3B3	CTLA-4	Inflammation/Immunology Cancer
JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma. ^[1]

Cat. No.	상품명	Target	Research Area	Image

HY-P9952

Belimumab 5 Publications Verification LymphoStat B	TNF Receptor CD20	Inflammation/Immunology Cancer
Belimumab (LymphoStat B) is a humanized *IgG1λ* monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research ^[1] . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.

HY-P990006

Duvakitug TEV-48574; SAR-447189; TEV-574	TNF Receptor	Inflammation/Immunology
Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to *TNFSF15*/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) ^[1] .

HY-P99992

*Human IgG1* lambda1, Isotype Control** 2 Publications Verification	Inhibitory Antibodies	Metabolic Disease Inflammation/Immunology Cancer
Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer ^[1] .

HY-P990096

*Human IgG1* lambda2, Isotype Control**	Inhibitory Antibodies	Inflammation/Immunology
Human IgG1 lambda2, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1λ antibody. Isotype control antibodies can help remove non-specific signals from experimental results and assess the accuracy and reliability of the experiment ^[1].

HY-P99322

Tesidolumab LFG316; Anti-Human C5 Recombinant Antibody	Complement System	Inflammation/Immunology
Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex ^[1].

HY-P99621

Fiztasovimab NPC-21; EV2038	CMV	Infection
Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV ^[1].

HY-P990281

Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3)	Interleukin Related	Inflammation/Immunology
Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis ^[1] .

HY-P99039

Oleclumab 1 Publications Verification MEDI9447	CD73	Cancer
Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity ^[1] .

HY-P99588

Stamulumab 1 Publications Verification MYO-029	TGF-β Receptor	Metabolic Disease
Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research ^[1] .

HY-P99730

Mezagitamab 1 Publications Verification TAK-079	CD38 Apoptosis	Inflammation/Immunology Cancer
Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) ^[1] .

HY-P990015

Tobevibart VIR-3434	HBV	Infection
Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P99102

Zinlirvimab 10-1074	HIV	Infection
Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) ^[1] .

HY-P99103

Bebtelovimab LY-3853113; LY-COV1404	SARS-CoV	Infection
Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC₅₀ value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy ^[1] .

HY-P991381

JST-TfR09 PPMX-T003	Transferrin Receptor Reactive Oxygen Species (ROS) Ferroptosis	Cancer
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) ^[1] .

HY-P990911

Crebankitug ZB-168	Interleukin Related	Inflammation/Immunology
HY-P990911 is an IL7R-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P991737

*Rat IgG1* lambda, Isotype Control**	Inhibitory Antibodies	Inflammation/Immunology
Rat IgG1 lambda, Isotype Control, a rat-derived antibody, is an isotype control for rat IgG1λ antibody.

HY-P991717

Sunakiment AZD-8630	Interleukin Related	Inflammation/Immunology Cancer
Sunakiment is a humanized IgG1λ monoclonal antibody inhibitor targeting Thymic stromal lymphopoietin (TSLP). Sunakiment can be used for inflammatory and immune system disorders like ulcerative colitis, rheumatoid arthritis and allergy and cancers research ^[1] .

HY-P991651

MEDI4212	Fc Receptor (FcR)	Inflammation/Immunology
MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC₅₀ of 8 nM. MEDI4212 can be used severe asthma research ^[1].

HY-P991002

Indemakitug EI-001	Inhibitory Antibodies	Inflammation/Immunology
HY-P991002 is an IFNG-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990014

Danburstotug IMC-001; STI-3031	PD-1/PD-L1	Inflammation/Immunology Cancer
Danburstotug (IMC-001) is an IgG1-lambda anti-CD274 (PDL1, B7 homologue 1, B7H1) human monoclonal antibody. Danburstotug also is immunostimulant and antineoplastic ^[1].

HY-P99871

Ebronucimab AK102	PCSK9	Others
Ebronucimab (AK102) is an IgG1-λ2 antibody targeting PCSK9 and is primarily expressed by CHO DG44 (Chinese Hamster Ovary) cells ^[1].

HY-145641

Crexavibart BMS-986413; C-144-LS	SARS-CoV	Infection
Crexavibart (BMS-986413; C-144-LS) is an IgG1_λ2 antibody that targets the SARS-CoV2 spike (S) glycoprotein receptor-binding domain ^[1].

HY-P990999

Imeroprubart IMVT-1402	Inhibitory Antibodies	Inflammation/Immunology
HY-P990999 is an FCGRT-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990259

Anti-Mouse CD96 Antibody (3.3)	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Anti-Mouse CD96 Antibody (3.3) is a rat-derived anti-mouse CD96 IgG1 λ type antibody inhibitor. Anti-Mouse CD96 Antibody (3.3) blocks binding of CD155 to CD96. Anti-Mouse CD96 Antibody (3.3) can enhance the antitumor efficacy of multiple immune-checkpoint inhibitors. Anti-Mouse CD96 Antibody (3.3) shows potent anti-tumor and anti-metastatic activity in various tumor models. Anti-Mouse CD96 Antibody (3.3) can be used for the researches of cancer and inflammation, such as mammary carcinoma ^[1] .

HY-P990922

Indenebart MEDI-1341; TAK-341	Sodium Channel	Inflammation/Immunology
HY-P990922 is an SNCA-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990924

Libevitug	HBV	Inflammation/Immunology
HY-P990924 is an HBV-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990971

Atenastobart	TNF Receptor	Inflammation/Immunology
HY-P990971 is an TNFRSF9-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990900

Ansipastobart	CD73	Inflammation/Immunology
HY-P990900 is an NT5E-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P990899

Amostomig	CD47	Inflammation/Immunology
HY-P990899 is an CD274/CD47-targeting IgG1λ2 type humanized antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) ^[1].

HY-P991959

JMW-3B3	CTLA-4	Inflammation/Immunology Cancer
JMW-3B3 is a humanized IgG1λ monoclonal antibody targeting CTLA-4. JMW-3B3 selectively binds the unique C-terminal sequence of sCTLA-4 to block its immunoregulatory and immunosuppressive activity without cross-reacting with full-length CTLA-4 receptor. JMW-3B3 enhances cytokine profiles in PBMC cultures responding to lupus autoantigen-derived peptides. JMW-3B3 enhances IFN-γ production in anti-CD3 stimulated PBMC from melanoma patients at low anti-CD3 doses. JMW-3B3 can be used for the research of systemic lupus erythematosus and malignant melanoma. ^[1]

HY-P992489

*Mouse IgG1* lambda, Isotype Control**	Inhibitory Antibodies	Inflammation/Immunology
Mouse IgG1 lambda, Isotype Control is an isotype control for?Mouse IgG1 lambda.

Cat. No.	Compare	상품명	Application	Reactivity	Image

HY-P89504

	*Rat IgG1 lambda* Isotype Control antibody (YA8871)**	WB, IHC-P, IHC-F, IF-Tissue, FC, ICC/IF, ELISA	species independent
	Rat IgG1 lambda Isotype Control antibody (YA8871) is a Non-conjugated and Rat origined monoclonal antibody, It can be used as an Rat IgG1, lambda isotype control.

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