35 Results for "

IgG1λ

" in MedChemExpress (MCE) Product Catalog:
Products (35)

35 Results for "IgG1λ" in MCE Product Catalog:

6
6 Publications Verification
Cat. No.: HY-P9952
CAS No.: 356547-88-1
Synonyms: LymphoStat B
Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research [1] . The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.
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2
2 Cited Publications
Cat. No.: HY-P99992
Human IgG1 lambda1, Isotype Control, a human-derived antibody, is an isotype control for human IgG1λ1 antibody. Human IgG1 lambda1, Isotype Control can be used in the research of diabetes and pancreatic cancer [1] .
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1 Cited Publications
Cat. No.: HY-P990006
CAS No.: 2750005-84-4
Synonyms: TEV-48574; SAR-447189; TEV-574

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Duvakitug (TEV-48574) is a humanized IgG1-λ2 monoclonal antibody targeting to TNFSF15/TL1A. Duvakitug' main expression system is CHOK1SV cells endogenously expressing glutamine synthetase (GS). Duvakitug can be used in the study of Crohn's Disease (CD) [1] .
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1 Cited Publications
Cat. No.: HY-P99039
CAS No.: 1803176-05-7
Synonyms: MEDI9447

Target:  

CD73

Research Areas:  

Cancer

Oleclumab (MEDI9447) is a human IgG1λ monoclonal antibody targeting CD73 and inhibits the exonuclease activity of the extracellular enzyme CD73. Oleclumab can adjust the composition of bone marrow and lymphoid infiltrating leukocyte populations in the tumor microenvironment and has anti-tumor activity [1] .
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1 Cited Publications
Cat. No.: HY-P99588
CAS No.: 705287-60-1
Synonyms: MYO-029

Target:  

TGF-β Receptor

Research Areas:  

Metabolic Disease

Stamulumab (MYO-029) is a recombinant human IgG1λ antibody that binds to myostatin and neutralizes its activity by preventing binding to its endogenous high-affinity receptor ActRIIB. Stamulumab leads to muscle fiber hypertrophy and not hyperplasia in SCID mice. Stamulumab has the potential for Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), and limb-girdle muscular dystrophy (LGMD) research [1] .
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1 Cited Publications
Cat. No.: HY-P99730
CAS No.: 2227490-52-8
Synonyms: TAK-079

Target:  

CD38 Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Mezagitamab (TAK-079) is a IgG1λ anti-CD38 monoclonal antibody. Mezagitamab depletes tumor cells expressing CD38 through antibody and complement dependent cytotoxicity. Mezagitamab has potential application in relapsed/refractory multiple myeloma (RRMM) and idiopathic thrombocytopenic purpura (ITP) [1] .
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1 Cited Publications
Cat. No.: HY-P99103
CAS No.: 2578319-11-4
Synonyms: LY-3853113; LY-COV1404

Target:  

SARS-CoV

Research Areas:  

Infection

Bebtelovimab a human IgG1-λ2 antibody targeting to SARS-CoV-2, especially COVID-19 ((the IC50 value for SARS-CoV-2/MT020880.1 virus is 9-22.1 ng/mL)). Bebtelovimab potently neutralizes SARS-CoV-2 variants, and inhibits COVID-19 with mild-to-moderate efficacy [1] .
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Cat. No.: HY-P990096

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Human IgG1 lambda2, Isotype Control is a human monoclonal antibody that is the isotype control of human IgG1λ antibody. Isotype control antibodies can help remove non-specific signals from experimental results and assess the accuracy and reliability of the experiment [1].
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Cat. No.: HY-P99322
CAS No.: 1531594-08-7
Synonyms: LFG316; Anti-Human C5 Recombinant Antibody

Target:  

Complement System

Research Areas:  

Inflammation/Immunology

Tesidolumab (LFG316) is a fully-human IgG1/λ anti-C5 monoclonal antibody of 143 kDa (without glycosylation). Tesidolumab (LFG316) blocks cleavage of C5 and prevents subsequent formation of the membrane attack complex [1].
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Cat. No.: HY-P99621
CAS No.: 2467411-25-0
Synonyms: NPC-21; EV2038

Target:  

CMV

Research Areas:  

Infection

Fiztasovimab (NPC-21; EV2038) is a fully human IgG1λ mAb against human cytomegalovirus (hCMV). Fiztasovimab acts neutralizing activity by binding to the antigenic domain 1 of glycoprotein B on hCMV envelope. Fiztasovimab inhibits cell-to-cell transmission of hCMV [1].
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Cat. No.: HY-P990281

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) is a rat-derived IgG1 λ type antibody inhibitor, targeting to mouse CD25/IL-2Rα. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can deplete CD25+ T cells. Anti-Mouse CD25/IL-2Rα Antibody (PC-61.5.3) can be used for the researches of immunology and inflammation, such as atopic dermatitis [1] .
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Cat. No.: HY-P990015
CAS No.: 2645440-65-7
Synonyms: VIR-3434

Target:  

HBV

Research Areas:  

Infection

Tobevibart (VIR-3434) is a human IgG1 lambda monoclonal antibody against hepatitis B virus (HBV) surface antigen (HBsAg). Tobevibart shows potent neutralization against HBsAg from all HBV genotypes in vitro and inhibits viral entry of HBV and hepatitis delta virus (HDV). Recommend Isotype Controls: Human IgG1 lambda2, Isotype Control (HY-P990096) [1].
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Cat. No.: HY-P9S0056
Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

Human IgG1 (L234A/L235A) lambda2, Isotype Control, is a human monoclonal antibody that serves as an isotype control for human IgG1λ antibody.
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Cat. No.: HY-P99102
CAS No.: 2417213-75-1
Synonyms: 10-1074

Target:  

HIV

Research Areas:  

Infection

Zinlirvimab is a human IgG1-λ2, HIV neutralising antibody targeting to HIV-1 gp120 envelope glycoprotein (IIIB gp120 V3 loop) [1] .
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Cat. No.: HY-P991381
Synonyms: PPMX-T003; TSP-A18
JST‑TfR09 (PPMX‑T003) is a human monoclonal antibody (mAb) targeting transferrin receptor 1 (TfR1/CD71). JST‑TfR09 blocks the binding of transferrin to TfR1, inhibits TfR1 internalization, and suppresses cellular iron uptake. JST‑TfR09 triggers ferritin degradation via activating the autolysosomal system, promotes ROS production and lipid peroxidation, and ultimately induces ferroptosis. JST‑TfR09 exhibits cytotoxicity toward human erythroblasts differentiated from hematopoietic stem cells. JST-TfR09 can be used in leukemia research. Recommended isotype control: Human IgG1 lambda, Isotype Control (HY-P99992) [1] .
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Cat. No.: HY-P990911
CAS No.: 2893793-17-2
Synonyms: ZB-168

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

HY-P990911 is an IL7R-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096) [1].
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Cat. No.: HY-P99709
CAS No.: 2118349-31-6
Synonyms: LY3300054

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Lodapolimab (LY3300054) is a fully human IgG1λ anti-PD-L1 monoclonal antibody, with an EC50 of 0.075 nM against hPD-L1 and an EC50 of 0.085 nM against cynomolgus monkey PD-L1. Lodapolimab induces naive T cell activation, enhances the T cell activation effect of anti-CTLA4 antibodies, promotes anti-tumor alloreactivity, regulates innate immune pathways, and induces characteristics of adaptive immune activation. Lodapolimab can be used in research related to high-grade serous ovarian cancer and other solid tumors [1] .
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Cat. No.: HY-P991737

Target:  

Inhibitory Antibodies

Research Areas:  

Others

Rat IgG1 lambda, Isotype Control, a rat-derived antibody, is an isotype control for rat IgG1λ antibody.
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Cat. No.: HY-P991717
CAS No.: 2928519-36-0
Synonyms: AZD-8630
Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Sunakiment (AZD-8630) is a humanized IgG1λ monoclonal antibody inhibitor targeting thymic stromal lymphopoietin (TSLP), which enables direct airway delivery via a dry powder inhaler formulation. Sunakiment binds to TSLP and blocks its pro-inflammatory signal transduction. It is applicable to research on refractory asthma, asthma, and moderate-to-severe asthma [1] .
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Cat. No.: HY-P991651

Target:  

Fc Receptor (FcR)

Research Areas:  

Inflammation/Immunology

MEDI4212 is a humanized IgG1λ monoclonal antibody inhibitor targeting IgE. MEDI4212 potently inhibits human IgE-mediated functional responses through its receptor FcεRI, such as calcium signaling, β-hexosaminidase release and phagocytosis. MEDI4212 prevents the binding of IgE to CD23 with an IC50 of 8 nM. MEDI4212 can be used severe asthma research [1].
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