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Results for "

KB-3-1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

7

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168528
    WS-917
    1 Publications Verification

    		 P-glycoprotein Cancer
    WS-917 is a potent and orally active ABCB1 modulator. WS-917 enhances ABCB1 ATPase activity. WS-917 significantly enhances the antitumor effect of paclitaxel combined with anti-PD-1 antibody. WS-917 promotes CD8 + T-cell activation .
    WS-917
  • HY-N15595
    Curvulol

    		Bacterial Fungal Infection
    Curvulol is an antimicrobial agent with a polyketide structure. Curvulol can be isolated from Taxus baccata ( Chaetosphaeronema achilleae). Curvulol has a significant cytotoxicity against L929 and KB-3-1 cells, and strongly inhibits Staphylococcus aureus biofilm formation with a MIC of 64 μg/mL .
    Curvulol
  • HY-N3702
    Dehydroabietinol

    		Syk Infection Inflammation/Immunology
    Dehydroabietinol is a SYK inhibitor with an IC50 of 46.4 μM. Dehydroabietinol inhibits the growth of Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes and Leishmania infantum promastigotes. Dehydroabietinol indirectly inhibits the growth of Plasmodium falciparum, alters the erythrocyte membrane, and induces spherostomatocyte transformation and endovesicle formation. Dehydroabietinol can be used in studies related to immune-mediated diseases, Chagas disease, leishmaniasis and malaria .
    Dehydroabietinol
  • HY-N16065
    Prenylterphenyllin

    		Bacterial Infection
    Prenylterphenyllin (Compound 1) is an antibacterial agent. Prenylterphenyllin can be isolated from marine-derived fungus Aspergillus candidus IF10. Prenylterphenyllin has cytotoxic activity against KB3-1 cells with an IC50 of 8.5 mg/mL. Prenylterphenyllin also has antibacterial activities against Xanthomonas oryzae and Erwinia amylovora with MICs of both 20 μg/mL .
    Prenylterphenyllin
  • HY-N15343
    Albiducin A

    		Antibiotic Bacterial Fungal Infection Cancer
    Albiducin A is an antibiotic found in Hymenoscyphus albidus, exhibiting antibacterial and anticancer activities. The MIC range of Albiducin A against bacteria and fungi is 16.7-66.7 mg/mL. Its IC50 values for mouse fibroblast cell line (L929) and human cervical carcinoma cell line (KB3-1) are 6.1 and 2.7 μg/mL, respectively. Albiducin A holds promise for research in the fields of infection and cancer diseases .
    Albiducin A
  • HY-N12606
    Neodidymelliosides A

    		Fungal Infection
    Neodidymelliosides A (compound 1)It is a secondary metabolite of fungi and has a significant inhibitory effect on Staphylococcus aureus and Candida albicans biofilms. Neodidymelliosides AIt also has anti-cancer activity and can inhibit KB3.1 (cervix),PC-3 (prostate),MCF-7(breast),SKOV-3 (ovary),A431 (skin )and A549 (lung )Cell viability of cell lines .
    Neodidymelliosides A
  • HY-N13196
    Arcopilin A

    		Bacterial Infection
    Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC50 values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively .
    Arcopilin A
  • HY-148193
    Tubulin polymerization-IN-38

    		ADC Payload Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs .
    Tubulin polymerization-IN-38
  • HY-N17304
    10S,13aR-Antofine N-oxide

    		Drug Derivative P-glycoprotein Cancer
    10S,13aR-Antofine N-oxide is a phenanthroindolizidine N-oxide alkaloid and cytotoxic agent found in Cynanchum vincetoxicum. 10S,13aR-Antofine N-oxide exerts cytotoxic effects in drug-sensitive (KB-3-1, IC50 = 0.11 μM) and multi-drug-resistant (KB-V1, IC50 = 0.16 μM) carcinoma cells. 10S, 13aR-Antofine N-oxide acts as a poor substrate for the P-glycoprotein (P-170) efflux pump. 10S,13aR-Antofine N-oxide can be used for the research of cancers .
    10S,13aR-Antofine N-oxide

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