1005192-31-3
Chemical Structure
Tubulin polymerization-IN-38
- CAS No.: 1005192-31-3
- Formula:C31H50N4O8S
- Molecular Weight:638.82
IUPAC Name: 2-((1R,3R)-1-acetoxy-4-methyl-3-((2S,3S)-3-methyl-N-(((3-methylbutanoyl)oxy)methyl)-2-((R)-1-methylpiperidine-2-carboxamido)pentanamido)pentyl)thiazole-4-carboxylic acid
InChIKey: FPUIRXUNKYZNGB-WSXDNQGXSA-N
SMILES: O=C(C1=CSC([C@H](OC(C)=O)C[C@@H](N(C([C@@H](NC([C@@H]2N(C)CCCC2)=O)[C@@H](C)CC)=O)COC(CC(C)C)=O)C(C)C)=N1)O
Biological Activity: Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs[1].
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Tubulin polymerization-IN-38 | Tubulin polymerization-IN-38 is an analogue of Tubulysin (HY-128914), a potent anticancer agent. Tubulin polymerization-IN-38 inhibits tubulin polymerization (tubulin polymerisation), thereby inducing apoptosis (apoptosis). Tubulysin series products are potent anti-microtubule toxins (anti-microtubule toxins) and can be used as ADC cytotoxins (ADC Cytotoxin) to synthesize ADCs. | |||||||||||||||||||||
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Keywords
