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KSP-IN-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168727
    KSP ligand 1

    		Kinesin Cancer
    KSP ligand 1 is a protein ligand that targets KSP (Kinesin), and it can be used to synthesize PROTAC KSP-IN-1 (HY-168725) for cancer research [1].
    KSP ligand 1
  • HY-179355
    KSP-IN-1

    		Kinesin Cancer
    KSP-IN-2 (compound 12) is a kinesin spindle protein (KSP) inhibitor with an IC50 of 450 nM [1].
    KSP-IN-1
  • HY-168725
    PROTAC KSP degrader 1

    		PROTACs Kinesin Apoptosis Cancer
    PROTAC KSP degrader 1 (Compound 21) is a PROTAC Degrader for kinesin spindle protein (KSP), that degrades KSP in HCT-116 with DC50 of 114.8 nM. PROTAC KSP degrader 1 inhibits the proliferation of HCT-116 with IC50 of 10 nM, arrests the cell cycle of HCT-116 at G2/M phase, and induces apoptosis in HCT-116. PROTAC KSP degrader 1 exhibits antitumor efficacy in mouse model [1]. (Blue: Ligand for E3 Ligase Cereblon (HY-103596); Blank: Linker (HY-168726); Pink: Target Protein Ligand (HY-168727))
    PROTAC KSP degrader 1
  • HY-157338
    NHS-Ala-Ala-Asn-active metabolite

    		ADC Linker Kinesin Cancer
    NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor .
    NHS-Ala-Ala-Asn-active metabolite

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