64 Results for "

L-dopa

" in MedChemExpress (MCE) Product Catalog:
Products (64)

64 Results for "L-dopa" in MCE Product Catalog:

35
35 Publications Verification
Referencia número: HY-N0304
No. CAS: 59-92-7
Synonyms: Levodopa; 3,4-Dihydroxyphenylalanine
L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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35
35 Publications Verification
Referencia número: HY-N0304A
No. CAS: 63302-01-2
Synonyms: Levodopa sodium; 3,4-Dihydroxyphenylalanine sodium
L-DOPA (Levodopa) sodium is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA sodium can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA sodium has anti-allodynic effects, and can be used for Parkinson's disease research .
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7
7 Cited Publications
Referencia número: HY-B0404A
No. CAS: 14919-77-8
Synonyms: Ro 4-4602 hydrochloride
Target:  

Pyruvate Kinase

Áreas de investigación:  

Neurological Disease Cancer

Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma .
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7
7 Cited Publications
Referencia número: HY-121275
No. CAS: 322-35-0
Synonyms: Ro 4-4602
Target:  

Pyruvate Kinase

Áreas de investigación:  

Neurological Disease Cancer

Benserazide is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma .
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4
4 Cited Publications
Referencia número: HY-15257
No. CAS: 543906-09-8
Pureza:  99.88%
Synonyms: AFQ056
Target:  

mGluR

Áreas de investigación:  

Neurological Disease

Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease . Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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4
4 Cited Publications
Referencia número: HY-N2278
No. CAS: 99217-63-7
Synonyms: Leachianone E
Kushenol A (Leachianone E) is isolated from the root of Sophora flavescent. Kushenol A is a non-competitive tyrosinase inhibitor to block the conversion of L-tyrosine to L-DOPA, shows IC50 and Kivalues of 1.1 μM and 0.4 μM, respectively . Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM; Ki: 6.8 μM) and β-amylase . Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging .
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2
2 Cited Publications
Referencia número: HY-P1335
No. CAS: 103429-32-9
Target:  

Opioid Receptor

Áreas de investigación:  

Neurological Disease

CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .
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2
2 Cited Publications
Referencia número: HY-P1335A
Target:  

Opioid Receptor

Áreas de investigación:  

Neurological Disease

CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC50 of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC50=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .
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1
1 Cited Publications
Referencia número: HY-N0304R
No. CAS: 59-92-7
Synonyms: Levodopa (Standard); 3,4-Dihydroxyphenylalanine (Standard)
L-DOPA (Standard) is the analytical standard of L-DOPA. This product is intended for research and analytical applications. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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1
1 Cited Publications
Referencia número: HY-113468A
No. CAS: 300-48-1
Pureza:  99.16%
Synonyms: 3-Methoxy-L-tyrosine; 3-O-Methyl-L-dopa
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .
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1
1 Cited Publications
Referencia número: HY-N0304S2
No. CAS: 586971-29-1
L-DOPA- 13C is the 13C labeled L-DOPA . L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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1
1 Cited Publications
Referencia número: HY-18654
No. CAS: 1235318-89-4
Target:  

mGluR

Áreas de investigación:  

Neurological Disease

ADX88178 is an orally active, blood-brain barrier-penetrant, selective positive allosteric modulator of mGluR4, with an EC50 of 3.5 nM against hmGluR4. ADX88178 modulates mGlu4 activity, enhances glutamate-mediated receptor activation, and increases the apparent affinity of glutamate for the receptor. ADX88178 reverses haloperidol-induced catalepsy, potentiates the effects of levodopa (L-DOPA) and quinpirole, but fails to alleviate established abnormal involuntary movements, does not exacerbate L-DOPA-induced dyskinesia, and does not affect forelimb akinesia when administered alone. ADX88178 can be used in research related to L-DOPA-induced dyskinesia and Parkinson's disease .
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Referencia número: HY-162666
No. CAS: 3038770-25-8
Target:  

Potassium Channel

Áreas de investigación:  

Neurological Disease

TMEM175 modulator 1 (compound 47) is a TMEM175 modulator.TMEM175 modulator 1 modulates activity of the lysosomal potassium ion channel TMEM175.TMEM175 modulator 1 can be used for the research of parkinson’s disease, dementia, alzheimer’s disease, l-dopa induced dyskinesia .
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Referencia número: HY-116016
No. CAS: 37178-37-3
Pureza:  99.00%
Synonyms: L-dopa ethyl ester; Levodopa ethyl ester
Áreas de investigación:  

Neurological Disease

Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine .
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Referencia número: HY-132392S
No. CAS: 53587-29-4
Pureza:  98.80%
L-DOPA-2,5,6-d3 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain .
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Referencia número: HY-113468AS
No. CAS: 586954-09-8
Pureza:  ≥99.0%
Synonyms: 3-Methoxy-L-tyrosine-d3; 3-O-Methyl-L-dopa-d3
3-O-Methyldopa-d3 (3-Methoxy-L-tyrosine-d3) is deuterium labeled 3-O-Methyldopa (HY-113468A). 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA (HY-N0304) that can cross the blood-brain barrier (BBB). 3-O-Methyldopa inhibits the astrocyte-mediated protective effect of L-DOPA (HY-N0304) on dopaminergic neurons. In addition, 3-O-Methyldopa has certain antidepressant and neuroprotective activities. 3-O-Methyldopa can be used in the research of nervous system diseases such as depression and Parkinson's disease .
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Referencia número: HY-113357
No. CAS: 588-30-7
Pureza:  99.84%
m-Coumaric acid is a polyphenol metabolite from caffeic acid, formed by the gut microflora and the amount in human biofluids is diet-dependant. m-Coumaric acid is a BBB-penetrant metabolite of chlorogenic acid. m-Coumaric acid stimulates the cerebral nerves in vitro. m-Coumaric acid can evoke neurite outgrowth in hippocampal neuronal cells. m-Coumaric acid can promote neuronal differentiation. m-Coumaric acid increases spontaneous locomotor activity in mice by acting on the central nervous system. m-Coumaric acid inhibits the oxidation of L-dopa by epidermis tyrosinase. m-Coumaric acid attenuates non-catalytic protein glycosylation in retinas of diabetic rats .
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Referencia número: HY-B0927
No. CAS: 118-08-1
Synonyms: (-)-β-Hydrastine; (1R,9S)-β-Hydrastine
Hydrastine ((-)-β-Hydrastine; (1R,9S)-β-Hydrastine) is a selective competitive inhibitor of tyrosine hydroxylase (TH), inhibiting dopamine biosynthesis (IC50=20.7 μM, PC12 cells). Hydrastine also inhibits the organic cation transporter OCT1 (IC50=6.6 μM). Hydrastine may cause neuronal toxicity through mitochondrial dysfunction rather than oxidative stress damage, and can aggravate cell apoptosis when combined with L-DOPA. Hydrastine can be used to study Parkinson's disease-related dopaminergic neuronal damage .
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Referencia número: HY-N0304S
No. CAS: 713140-75-1
Synonyms: Levodopa-d6; 3,4-Dihydroxyphenylalanine-d6
L-DOPA-d6 is the deuterium labeled L-DOPA. L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease .
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Referencia número: HY-141647
No. CAS: 1614253-58-5
Áreas de investigación:  

Others

18F-Labeled L-dopa precursor is a precursor for synthesis of 18F-labeled L-dopa .
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